Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma

Authors

  • Ethel-Michele de Villiers

    Corresponding author
    1. Division for the Characterization of Tumor Viruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    • Division for the Characterization of Tumor Viruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
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  • This article is dedicated to Prof. Harald zur Hausen on the occasion of his retirement as head of the German Cancer Research Center (Deutsches Krebsforschungzentrum Heidelberg) with gratitude and appreciation for 20 years of leadership.

Abstract

Available data demonstrate an increase in the transcription of high-risk papillomaviruses by the 16α-hydroxylation of estrogens, which is in line with the epidemiologic data showing an increased cervical carcinogenesis risk for long-term contraceptive-using, HPV-infected women. No evidence exists for an increase in HPV-negative contraceptive users. © 2002 Wiley-Liss, Inc.

Ancillary