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A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk

  1. Peter Krippl1,†,*,
  2. Uwe Langsenlehner1,
  3. Wilfried Renner2,
  4. Babak Yazdani-Biuki2,
  5. Gerald Wolf3,
  6. Thomas C. Wascher2,
  7. Bernhard Paulweber4,
  8. Josef Haas5,
  9. Hellmut Samonigg1

Article first published online: 30 MAY 2003

DOI: 10.1002/ijc.11238

Issue

International Journal of Cancer

International Journal of Cancer

Volume 106, Issue 4, pages 468–471, 10 September 2003

Additional Information

How to Cite

Krippl, P., Langsenlehner, U., Renner, W., Yazdani-Biuki, B., Wolf, G., Wascher, T. C., Paulweber, B., Haas, J. and Samonigg, H. (2003), A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk. International Journal of Cancer, 106: 468–471. doi: 10.1002/ijc.11238

Author Information

  1. 1

    Department of Internal Medicine, Division of Oncology, Karl-Franzens University Graz, Austria

  2. 2

    Department of Internal Medicine, Karl-Franzens University Graz, Austria

  3. 3

    Department of Radiology, Division of Nuclear Medicine, Karl-Franzens University Graz, Graz, Austria

  4. 4

    Department of Internal Medicine, Landeskrankenanstalten Salzburg, Austria

  5. 5

    Department of Obstetrics and Gynecology, Karl-Franzens University Graz, Austria

  1. †

    Fax +43-316-385-3355

*Klinische Abteilung für Onkologie, Medizinische Universitätsklinik Graz, Auenbruggerplatz 15, A-8036 Graz, Austria

Publication History

  1. Issue published online: 1 JUL 2003
  2. Article first published online: 30 MAY 2003
  3. Manuscript Accepted: 10 APR 2003
  4. Manuscript Revised: 28 JAN 2003
  5. Manuscript Received: 23 SEP 2002

Funded by

  • Austrian Cancer Aid/Styria. Grant Number: 02/2002

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Keywords:

  • angiogenesis;
  • breast cancer;
  • epidemiology;
  • genetics

Abstract

A common 936 C/T polymorphism in the gene for the vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels. In our case-control study, we investigated the role of this polymorphism for breast cancer risk. VEGF genotype was determined in 500 women with breast cancer and 500 sex- and age-matched healthy control subjects. Carriers of a 936T-allele were more frequent among controls (29.4%) than among patients (17.6%; p = 0.000014). The odds ratio for carriers of a 936T-allele for breast cancer was 0.51 (95% confidence interval 0.38–0.70). Additionally, VEGF plasma levels were determined in 21 nonsmoking post-menopausal controls; carriers of a 936T allele had significantly lower levels (median 23 pg/ml; range 6–50 pg/ml) than noncarriers (37; 21–387; p = 0.034). We conclude that carriers of a VEGF 936T-allele are at decreased risk for breast cancer, this, however, requiring further confirmation in a larger study. © 2003 Wiley-Liss, Inc.

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