• 1
    Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of twenty-five major cancers in 1990. Int J Cancer 1999; 80: 82741.
  • 2
    Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993; 54: 594606.
  • 3
    Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg 2000; 122: 4451.
  • 4
    Atula S, Grenman R, Laippala P, Syrjanen S. Cancer of the tongue in patients younger than 40 years. A distinct entity? Arch Otolaryngol Head Neck Surg 1996; 122: 13139.
  • 5
    Lewin F, Norell SE, Johansson H, Gustavsson P, Wennerberg J, Biorklund A, Rutqvist LE. Smoking tobacco, oral snuff, and alcohol in the aetiology of squamous cell carcinoma of the head and neck. Cancer 1998; 82: 136775.
  • 6
    Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. N Engl J Med 2001; 345: 1890900.
  • 7
    Johnson N. Tobacco use and oral cancer: a global perspective. J Dent Educ 2001; 64: 32839.
  • 8
    McKaig RG, Baric RS, Olshan AF. Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head Neck 1998; 20: 25065.
  • 9
    Gillison ML, Wayne MK, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92: 70920.
  • 10
    Van Houten VMM, Snijders PJF, Van den Brekel MWM, Kummer JA, Meijer CJLM, Van Leeuwen B, Denkers F, Smeele LE, Snow GB, Brakenhoff RH. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer 2001; 93: 2325.
  • 11
    Franceschi S, Munoz N, Bosch XF, Snijders PJF, Walboomers JMM. Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence. Cancer Epidemiol Biomarkers Prev 1996; 5: 56775.
  • 12
    Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2: 34250.
  • 13
    Cullen AP, Reid R, Campion M, Lörincz AT. Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J Virol 1991; 65: 60612.
  • 14
    Koopman LA, Szuhai K, Van Eendenburg JJDH, Bezrookove V, Kenter GG, Schuuring E, Tanke H, Fleuren GJ. Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines. Cancer Res 1999; 59: 561524.
  • 15
    Hopman AHN, Smedts F, Ummelen M, Dignef W, Speel EJM, Ramaekers FCS. Highly sensitive detection of human papillomavirus in cervical CIN lesions, microinvasive and invasive carcinoma. Cytometry 2002; Suppl 11: 71 [abstract 44083].
  • 16
    Münger K, Scheffner M, Huibregtse JM, Howley PM. Interactions of HPV E6 and E7 oncoproteins with tumor suppressor gene products. Cancer Surv 1992; 12: 197217.
  • 17
    Kubbutat MHG, Vousden KH. Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies. Semin Virol 1996; 7: 295304.
  • 18
    Snijders PJF, Steenbergen RDM, Top B, Scott SD, Meijer CJLM, Walboomers JMM. Analysis of p53 status in tonsillar carcinomas associated with human papillomavirus. J Gen Virol 1994; 75: 276975.
  • 19
    Barten M, Ostwald C, Mildelangosch K, Müller P, Wukasch Y, Löning T. HPV DNA and p53 alterations in oropharyngeal carcinomas. Virchows Arch 1995; 427: 1537.
  • 20
    Fouret P, Dabit D, Sibony M, Alili D, Commo F, Saint-Guily JL, Callard P. Expression of p53 protein related to the presence of human papillomavirus infection in precancerous lesions of the larynx. Am J Pathol 1995; 146: 599604.
  • 21
    Scholes AGM, Liloglou T, Snijders PJF, Hart CA, Jones AS, Woolgar JA, Vaughan ED, Walboomers JJM, Field JK. P53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck. Int J Cancer 1997; 71: 7969.
  • 22
    Veltman JA, Van Weert I, Aubele M, Bot FJ, Ramaekers FCS, Manni JJ, Hopman AHN. Specific steps in the aneuploidization correlate with loss of heterozygosity of 9p21, 17p13 and 18q21 in the progression of pre-malignant laryngeal lesions. Int J Cancer 2001; 91: 1939.
  • 23
    Poddighe PJ, Bulten J, Kerstens HMJ, Robben JCM, Melchers WJG, Hanselaar AGJM. Human papillomavirus detection by in situ hybridization signal amplification based on biotinylated tyramine deposition. J Clin Pathol Mol Pathol 1996; 49: M3404.
  • 24
    Zehbe I, Hacker GW, Su H, Hauser-Kronberger C, Hainfield JF, Tubbs R. Sensitive in situ hybridization with catalyzed reporter deposition, streptavidin-nanogold, and silver acetate autometallography. Detection of single-copy human papillomavirus. Am J Pathol 1997; 150: 155361.
  • 25
    Cooper K, Herrington CS, Stickland JE, Evans MF, McGee JO'D. Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridization. J Clin Pathol 1991; 44: 9906.
  • 26
    Lizard G, Roignot P, Brunet-Lecomte P, Chardonnet Y. Morphological analysis of in situ hybridization signals in cervical intraepithelial neoplasia containing human papillomavirus type 16 or 18: relationship with histological grade and DNA content. Cytometry 1998; 34: 1806.
  • 27
    Van der Toorn P-PG, Veltman JA, Bot FJ, De Jong JMA, Manni JJ, Ramaekers FCS, Hopman AHN. Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells. J Pathol 2001; 193: 6672.
  • 28
    Hopman AHN, Kamps MAF, Speel EJM, Schapers RFM, Sauter G, Ramaekers FCS. Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma in situ of the urinary bladder versus carcinoma in situ associated with carcinoma. Am J Pathol 2002; 161: 111925.
  • 29
    Speel EJM, Ramaekers FCS, Hopman AHN. Sensitive multicolor fluorescence in situ hybridization using catalyzed reporter deposition (CARD) amplification. J Histochem Cytochem 1997; 45: 143946.
  • 30
    Hopman AHN, Ramaekers FCS, Speel EJM. Rapid synthesis of biotin-, digoxigenin-, trinitrophenyl-, and fluorochrome-based tyramides and their application for in situ hybridization using CARD amplification. J Histochem Cytochem 1998; 46: 7717.
  • 31
    Taylor D, Kock WM, Zahurak M, Shah K, Sidransky D, Westra WH. Immunohistochemical detection of p53 protein accumulation in head and neck cancer: correlation with p53 gene alterations. Hum Pathol 1999; 30: 11215.
  • 32
    Wiest T, Schwartz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV 16 E6/E7 expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 2002; 21: 15107.
  • 33
    Klaes R, Woerner SM, Ridder R, Wentzensen N, Duerst M, Schneider A, Lotz B, Melsheimer P, Von Knebel Doeberitz M. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999; 59: 61326.
  • 34
    Van der Sijp JRM, Van Meerbeeck JPAM, Maat APWM, Zondervan PE, Sleddens HF, Van Geel AN, Eggermont AM, Dinjens WN. Determination of the molecular relationship between multiple tumors within one patient is of clinical importance. J Clin Oncol 2002; 20: 110514.
  • 35
    Görtz B, Roth J, Speel EJM, Krähenmann A, De Krijger RR, Matias-Guiu X, Muletta-Feurer S, Rütimann K, Saremaslani P, Heitz PU, Komminoth P. MEN1 gene mutation analysis of sporadic adrenocortical lesions. Int J Cancer 1999; 80: 3739.
  • 36
    Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, Eckel HE, Dienes HP, Pfister HJ, Fuchs PG. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001; 92: 287584.
  • 37
    Brandsma JL, Abramson AL. Association of papillomavirus with cancers of the head and neck. Arch Otolaryngol Head Neck Surg 1989; 115: 6215.
  • 38
    Crum CP. Detecting every genital papilloma virus infection. What does it mean? Am J Pathol 1998; 153: 166771.
  • 39
    Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM, Mao EJ, Fitzgibbons ED, Huang S, Beckmann AM, McDougall JK, Galloway DA. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 1998; 90: 162636.
  • 40
    Veltman JA, Hopman AHN, Bot FJ, Ramaekers FCS, Manni JJ. Detection of chromosomal aberrations in cytologic brushes from head and neck squamous cell carcinoma. Cancer Cytopathol 1997; 81: 30914.
  • 41
    Wilczynski SP, Lin BTY, Xie Y, Paz IB. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol 1998; 152: 14556.
  • 42
    Frish M, Biggar RJ. Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas. Lancet 1999; 354: 14423.
  • 43
    Francesschi S, Munoz N, Snijders PJF. How strong and how wide is the link between HPV and oropharyngeal cancer? Lancet 2000; 356: 8712.
  • 44
    Sisk EA, Soltys SG, Zhu S, Fisher SG, Carey TE, Bradford CR. Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma. Head Neck 2002; 24: 8419.
  • 45
    Kropveld A, Rozemuller EH, Leppers FG, Scheidel KC, De Weger RA, Koole R, Hordijk GJ, Slootweg PJ, Tilanus MG. Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers. Lab Invest 1999; 79: 34753.
  • 46
    Susuki H, Tomida A, Tsuruo T. Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 2001; 20: 577988.
  • 47
    Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti CA, Bevilacqua G. MDM2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 mutations. Diagn Mol Pathol 1995; 4: 937.
  • 48
    Lindel K, Beer K, Laissue J, Geiner RH, Aebersold DM. Human papillomavirus positive squamous cell carcinoma of the oropharynx. A radiosensitive subgroup of head and neck carcinoma. Cancer 2001; 92: 80513.
  • 49
    Sisk EA, Bradford CR, Jacob A, Yian CH, Staton KM, Tang G, Harris MO, Carey TE, Lancaster WD, Gregoire L. Human papillomavirus infection in “young” versus “old” patients with squamous cell carcinoma of the head and neck. Head Neck 2000; 22: 64957.