The first 2 authors contributed equally to this work.
Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial†
Version of Record online: 12 SEP 2003
Copyright © 2003 Wiley-Liss, Inc.
International Journal of Cancer
Volume 107, Issue 5, pages 811–816, 10 December 2003
How to Cite
Hogewoning, C. J.A., Bleeker, M. C.G., van den Brule, A. J.C., Voorhorst, F. J., Snijders, P. J.F., Berkhof, J., Westenend, P. J. and Meijer, C. J.L.M. (2003), Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial. Int. J. Cancer, 107: 811–816. doi: 10.1002/ijc.11474
This work is dedicated to Jan M.M. Walboomers, who passed away on 2 February 2000. He was one of the principal investigators of this project.
- Issue online: 14 OCT 2003
- Version of Record online: 12 SEP 2003
- Manuscript Accepted: 18 JUL 2003
- Manuscript Revised: 1 JUL 2003
- Manuscript Received: 13 MAR 2003
- Dutch Prevention Fund/Zorg Onderzoek Nederland. Grant Number: 28-2725
- cervical intraepithelial neoplasia;
- human papillomavirus;
- condom use;
- clinical course
Women with persistent HPV infections have increased risk of progressive CIN lesions. Transmission of HPV between sexual partners might maintain viral infection and, consequently, may influence the clinical course of CIN. We investigated the effect of condom use on regression of CIN lesions and on clearance of HPV. Women with CIN and their male sexual partners were randomized for condom use (condom group n = 72 and noncondom group n = 76). They were conservatively managed and followed every 3–6 months by colposcopy, cytology and HPV testing by GP5+/6+ PCR. Baseline cervical biopsy specimens were taken. Median follow-up time for women was 15.2 months (range 3.0–85.4). Outcomes of interest were clinical regression of CIN at colposcopy and clearance of HPV. Outcomes were assessed in 64 women of the condom group and 61 women of the noncondom group. Women in the condom group showed a 2-year cumulative regression rate of 53% vs. 35% in the noncondom group (p = 0.03). The 2-year cumulative rates of HPV clearance were 23% vs. 4%, respectively (p = 0.02). Although lower regression rates were found if women were HPV-positive and had ≥CIN2 lesions at baseline, effects of condom use were found both in women with CIN1 and in women with ≥CIN2 lesions. Condom use promotes regression of CIN lesions and clearance of HPV. © 2003 Wiley-Liss, Inc.