Fax: +972-0-2-6427485
Cancer Genetics
You have full text access to this OnlineOpen article
Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers
Article first published online: 28 OCT 2003
DOI: 10.1002/ijc.11531
Copyright © 2003 Wiley-Liss, Inc.
Additional Information
How to Cite
Kadouri, L., Kote-Jarai, Z., Easton, D. F., Hubert, A., Hamoudi, R., Glaser, B., Abeliovich, D., Peretz, T. and Eeles, R. A. (2004), Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. Int. J. Cancer, 108: 399–403. doi: 10.1002/ijc.11531
Publication History
- Issue published online: 21 NOV 2003
- Article first published online: 28 OCT 2003
- Manuscript Accepted: 31 JUL 2003
- Manuscript Revised: 10 JUN 2003
- Manuscript Received: 17 DEC 2002
Funded by
- Barclay Fellowship through the British Council
- Radlette Synagogue Community
- Legacy from M. Silcock
- T. Maxse and H. Knowles in memory of G. Knowles
REFERENCES
- 1, , . Breast Cancer Linkage Consortium. Breast and ovarian cancer incidence in BRCA1 mutation carriers. Am J Hum Genet 1995; 56: 265–71.
- 2, , , , , , , , , , , , et al. Genetic heterogeneity and penetrance analysis of BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998; 62: 676–89.
- 3, , , , , , , , . The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 1997; 336: 1401–8.
- 4, , , , , , , , . Population-based study of risk of breast cancer in carriers of BRCA2 mutations. Lancet 1998; 352: 1337–9.
- 5, , , , , , , , , . AIB1, a steroid coactivator amplified in breast and ovarian cancer. Science 1997; 277: 965–8.
- 6
- 7, , , , , , . In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin Cancer Res 1998; 4: 2925–9.
- 8, , . Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/new. Cancer Res 2001; 61: 903–7.
- 9, , , , , , . Specific aberration and amplification of AIB1 in pancreatic cancer. Am J Pathol 1999; 154: 530–6.
- 10, , , , , , , , , , . Amplification and over-statement of the AIB1 nuclear receptor co-activator gene in primary gastric cancer. Int J Cancer 2000; 89: 217–23.Direct Link:
- 11, , , , , , , , , , , , . Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci USA 2000; 97: 13549–54.
- 12, , . Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene). Clin Genet 1998; 54: 102–3.Direct Link:
- 13, , , , , , . Polymorphism of homopolymorphic glutamine in coactivators for nuclear hormone receptors. Endocrine J 1999; 46: 279–84.
- 14, , , , , , , , , , , , et al. Modification of BRCA1 and BRCA2 associated breast cancer risk by the AIB1 genotype and reproductive history. Cancer Res 2001; 61: 5420–4.
- 15, , , , , , , . Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Res 2000; 2: 378–85.
- 16, , , , , , . A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br J Cancer 2002; 86: 76–83.
- 17
- 18, , , , , , , , , . CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers. Br J Cancer 2001; 85: 36–40.
- 19, , . Floating absolute risks—an alternative to choosing an arbitrary group in survival analysis and case-control studies. Stat Med 1991; 10: 1025–35.Direct Link:
- 20, , , , , , , , , , , , et al. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nat Genet 1996; 12: 309–11.
- 21, , , , , , , , , , . Modification of BRCA1-associated breast cancer risk by polymorphic androgen-receptor CAG repeat. Am J Hum Genet 1999; 64: 1371–7.
- 22, , , , , , , , , , , , et al. A single nucleotide polymorphism in the 5′ untranslated region of RAD51 risk of cancer among BRCA1/2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2001; 10: 955–60.
- 23, , , , , , , , , , . A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. Proc Natl Acad Sci USA 2001; 98: 3232–6.
- 24, , , , , , , , , . Autosomal dominant cerebellar ataxia (SCA6) associated with polyglutamine expansions in the a1A-voltage-dependent calcium channel. Nat Genet 1997; 15: 62–9.
- 25, , , , , , , , , , , , et al. Cloning of the SCA7 gene reveals a highly unstable CAG expansion. Nat Genet 1997; 17: 65–70.
- 26, , , , . Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991; 352: 77–9.
- 27, , , , , , . Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst 1997; 89: 166–70.
- 28, , , , , , . The CAG repeat within the androgen receptor gene in male breast cancer patients. J Med Genet 2000; 37: 139–40.
- 29, , . The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acid Res 1994; 22: 3181–6.
- 30, , , , , , . Transcriptional activation modulated by homopolymorphic glutamine and proline stretches. Science 1994; 263: 808–11.
- 31, , , , , , , , . Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer (AIB1) are associated with quantitative calcaneal ultrasound. J Bone Miner Res 2000; 15: 2231–9.Direct Link:
- 32, , , , , , , . Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk. Mol Genet Metab 2001; 72: 144–54.
- 33, . The pathology of inherited breast cancer. Pathology 2002; 34: 309–14.
- 34, , , . Hormone dependent regulation of BRCA1 in human breast cancer cells. Cancer Res 1995; 55: 4561–5.
- 35, , , , , , , , , , . BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 1999; 284: 1354–6.
- 36, . BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogen 1996; 13: 1639–45.
- 37, , , . BRCA2 is coordinately regulated with BRCA1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci USA 1996; 93: 13078–83.
- 38, , , , , , , , , , , . Risk-reducing salpingo-oophorectomy in women with BRCA1 or BRCA2 mutation. N Engl J Med 2002; 346: 1609–15.
- 39, , , , , , , , , , , . Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med 2002; 346: 1616–22.
- 40, , , , . BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc Natl Acad Sci USA 2001; 98: 9578–92.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
