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Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma
Article first published online: 28 OCT 2003
DOI: 10.1002/ijc.11601
Copyright © 2003 Wiley-Liss, Inc.
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How to Cite
Stebbing, J., Gazzard, B., Newsom-Davis, T., Nelson, M., Patterson, S., Gotch, F., Mandalia, S. and Bower, M. (2004), Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma. Int. J. Cancer, 108: 473–474. doi: 10.1002/ijc.11601
Publication History
- Issue published online: 21 NOV 2003
- Article first published online: 28 OCT 2003
- Manuscript Accepted: 12 SEP 2003
- Manuscript Received: 14 AUG 2003
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Keywords:
- Kaposi's sarcoma;
- B cells;
- humoral immunity
Abstract
Infection with HIV-1 is known to impair B cell function. To further elucidate the role of B cells during infection and tumorigenesis, we studied their numbers in cases of AIDS-related Kaposi's sarcoma (KS) during the HAART era. Patients with AIDS-related KS were identified from a database of 4,480 HIV-1 positive individuals and the incidence of KS and rate ratio was stratified according to nadir number of B cells, measured as the CD19 count. In an unadjusted model, we observed that lower B cell counts were associated with a statistically significant increased risk of KS development (p < 0.001). We also observed a trend toward increased counts during KS resolution. When adjusted for nadir CD4 count in a multi-variable model, higher B cell counts were protective against KS development (p = 0.015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis. © 2003 Wiley-Liss, Inc.