Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins

Authors

  • Stefan Duensing,

    Corresponding author
    1. Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA, USA
    • Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion Suite 1.8, 5117 Centre Avenue, Pittsburgh, PA 15213
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    • Fax: 412-623-7715

  • Karl Münger

    Corresponding author
    1. Department of Pathology, Harvard Medical School, Boston, MA, USA
    • Department of Pathology, Harvard Medical School, NRB, Room 0958c, 77 Avenue Louis Pasteur, Boston, MA 02115
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    • Fax: +412-432-0426


Abstract

Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis. © 2003 Wiley-Liss, Inc.

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