Epidemiology and Cancer Prevention

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Incidence of leukemia and other cancers in Down syndrome subjects in Israel

  1. L. Keinan Boker1,2,†,*,
  2. Tzvia Blumstein1,
  3. Siegal Sadetzki1,3,
  4. Osnat Luxenburg4,
  5. Irit Litvak5,
  6. Edna Akstein5,
  7. Baruch Modan1,3

Article first published online: 30 MAY 2001

DOI: 10.1002/ijc.1383

Issue

International Journal of Cancer

International Journal of Cancer

Volume 93, Issue 5, pages 741–744, 1 September 2001

Additional Information

How to Cite

Boker, L. K., Blumstein, T., Sadetzki, S., Luxenburg, O., Litvak, I., Akstein, E. and Modan, B. (2001), Incidence of leukemia and other cancers in Down syndrome subjects in Israel. Int. J. Cancer, 93: 741–744. doi: 10.1002/ijc.1383

Author Information

  1. 1

    Department of Clinical Epidemiology, Chaim Sheba Medical Center, Ramat Gan, Israel

  2. 2

    Julius Center for Patient Oriented Research, University Medical Center Utrecht, Utrecht, The Netherlands

  3. 3

    Department of Clinical Epidemiology, Tel Aviv University Medical School, Tel Aviv, Israel

  4. 4

    Ministry of Health, Jerusalem, Israel

  5. 5

    Israeli Registry for DS Births, Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel

  1. †

    Fax: +31-30-2505485

*Julius Center for Patient Oriented Research, University Medical Center Utrecht (UMCU), P.O.B. 85500, 3508 GA Utrecht, The Netherlands

Publication History

  1. Issue published online: 22 JUL 2001
  2. Article first published online: 30 MAY 2001
  3. Manuscript Accepted: 23 MAR 2001
  4. Manuscript Revised: 15 MAR 2001
  5. Manuscript Received: 13 OCT 2000

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REFERENCES

  • 1
    Cooley WC, Graham JM. Common syndromes and managements issues for primary care physicians. Down syndrome—an update and review for the primary physician. Clin Pediatr 1991;30: 233–53.
  • 2
    Hayes A, Batshaw ML. Down syndrome. Pediatr Clin North Am 1993;40: 523–35.
  • 3
    Evans DIK, Steward JK. Down syndrome and leukemia. Lancet 1972;16: 1032.
  • 4
    Rowely JD. Hypothesis: Down syndrome and acute leukemia: increased risk may be due to trisomy 21. Lancet 1981;7: 1020–2.
  • 5
    Fong C, Brodeur GM. Down syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukomogenesis. Cancer Genet Cytogenet 1987;28: 55–76.
  • 6
    Levitt GA, Stiller CA, Chessels JM. Prognosis of Down syndrome with acute leukemia. Arch Dis Child 1990;65: 212–6.
  • 7
    Lange BJ, Kobrinsky N, Barnard DR, Arthur DC, Buckley JD, Howells WB, et al. Distinctive demography, biology and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: children cancer group studies 2861 and 2891. Blood 1998;91: 608–15.
  • 8
    Sacchi N. Down syndrome and chromosome 21 abnormalities in leukemia. Bailliere's Clin Hematol 1992;5: 815–31.
  • 9
    Gassmann W, Loffler H. Acute megakaryoblastic leukemia. Leuk Lymphoma 1995;18s: 69–73.
  • 10
    Zipursky A, Christesen H, De Harven E. Ultrastructural studies of megakaryoblastic leukemias of Down syndrome. Leuk Lymphoma 1995;18: 341–7.
  • 11
    Bhatt S, Schreck R, Graham JM, Korenberg JR, Hurvitz CG, Fischel-Ghodsian N. Transient leukemia and trisomy 21: description of a case and review of the literature. Am J Med Genet 1995;58: 310–4.
    Direct Link:
  • 12
    Papas TS, Watson DK, Sacchi N, Fujiwara S, Seth AK, Fisher RJ, et al. ETS family of genes in leukemia and Down syndrome. Am J Med Genet 1990;7s: 251–61.
    Direct Link:
  • 13
    Rothman KJ, Boice JD, Jr. Epidemiologic analysis with programmable calculator. Washington, DC: USA 6PO DHEW publications (NIH), 1979: 79–1649.
  • 14
    Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 2000;355: 165–9.
  • 15
    Thase ME. Longevity and mortality in Down syndrome. J Ment Defic Res 1982;26: 177–93.
  • 16
    Shcoll T, Stein Z, Hansen H. Leukemia and other cancers, anomalies and infections as causes of death in Down syndrome in the United States during 1976. Dev Med Child Neurol 1982;24: 8817–29.
  • 17
    Satge D, Sommelet D, Geneix L, Nishi M, Malet P, Vekemans M. A tumor profile in Down syndrome. Am J Med Genet 1998;78: 207–16.
    Direct Link:
  • 18
    Satge D, Sasco AJ, Carlsen NLT, Stiller CA, Rubie H, Hero B, et al. A lack of neuroblastoma in Down syndrome: a study from 11 European countries. Cancer Res 1998;58: 448–52.
  • 19
    Mayer RJ. Gastrointestinal tract cancer. In: FauciAS, BraunwaldE, IsselbacherKJ, WilsonJD, MartinJB, KasperDL, et al., eds. Harrison's principles of internal medicine, 14th ed. New York: McGraw-Hill, 1998. p 568–78.
  • 20
    Tominaga S. Major avoidable risk factors of cancer. Cancer Lett 1999;143s: 19–23.
  • 21
    Peuschal SM. Clinical aspects of Down syndrome from infancy to adulthood. Am J Med Genet 1990;7s: 52–6.
    Direct Link:
  • 22
    Ugazio AG, Maccario R, Notarangelo LD, Burgio GR. Immunology of Down syndrome: a review. Am J Med Genet 1990;7s: 204–12.
    Direct Link:
  • 23
    Cuadrado E, Barrena MJ. Immune dysfunction in Down syndrome: primary immune deficiency or early senescence of the immune system? Clin Immuno Immunopathol 1996;78: 209–14.
  • 24
    Sakata K, Tamura G, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, et al. Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach. Genes Chromosomes Cancer 1997;18: 318–21.
    Direct Link:
  • 25
    Monakhov AS, Gulyaev AV, Savochkina IV, Hanson KP. Medico-genetic and cytogenetic study of a family with high predisposition to malignant disease in gastro-intestinal tract. J Exp Clin Cancer Res 1997;16: 385–8.
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