HLA class II alleles associated with infection by HPV16 in cervical cancer in situ
Version of Record online: 16 JUN 2001
Copyright © 2001 Wiley-Liss, Inc.
International Journal of Cancer
Volume 93, Issue 6, pages 817–822, 15 September 2001
How to Cite
Beskow, A. H., Josefsson, A. M. and Gyllensten, U. B. (2001), HLA class II alleles associated with infection by HPV16 in cervical cancer in situ. Int. J. Cancer, 93: 817–822. doi: 10.1002/ijc.1412
- Issue online: 13 AUG 2001
- Version of Record online: 16 JUN 2001
- Manuscript Accepted: 10 APR 2001
- Manuscript Revised: 5 APR 2001
- Manuscript Received: 22 JAN 2001
- Swedish Cancer Foundation. Grant Number: 3436-B97-04XAA
- National Institutes of Health (USA). Grant Number: NR 1 RO1 CA61197-01A3
- cervical cancer
HLA class II alleles have been associated with an increased risk of developing cervical cancer through infection with oncogenic forms of human papilloma virus (HPV). We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective case-control study. The infection history of a woman was studied by analysis of cervical smears taken at multiple times during a period of up to 27 years (1969–95). The frequency of a number of alleles are either increased (DRB1*0801, DRB1*1501, DQB1*0402 and DQB1*0602) or decreased (DRB1*0101, DRB1*1301, DQB1*0501 and DQB1*0603) in the cancer patients compared to the controls. After correction for multiple testing, only the DQB1*0602 and the DRB1*1501 alleles remain associated with cancer and only in HPV16-infected patients (DQB1*0602: 102/264 (39%) vs. 130/476 (28%), p = 0.028 and DRB1*1501: 104/259 (40%) vs. 132/469 (28%), p = 0.027). These alleles are associated primarily with infection by HPV and only indirectly affect the risk of developing cervical cancer in situ. To study the impact of these alleles on persistence of infection, women with short-term infections were compared to those with long-term infections. Carriers of DQB1*0602 and DRB1*1501 were more frequent in the group with long-term HPV infections, indicating that these class II alleles contribute to the inability to clear an HPV infection. © 2001 Wiley-Liss, Inc.