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Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy
Article first published online: 22 JAN 2004
DOI: 10.1002/ijc.20005
Copyright © 2004 Wiley-Liss, Inc.
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How to Cite
Basu, S., Brown, J. E., Flannigan, G. M., Gill, J. H., Loadman, P. M., Martin, S. W., Naylor, B., Scally, A. J., Seargent, J. M., Shah, T., Puri, R. and Phillips, R. M. (2004), Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy. Int. J. Cancer, 109: 703–709. doi: 10.1002/ijc.20005
Publication History
- Issue published online: 27 FEB 2004
- Article first published online: 22 JAN 2004
- Manuscript Accepted: 15 OCT 2003
- Manuscript Revised: 30 SEP 2003
- Manuscript Received: 4 AUG 2003
Funded by
- Cancer Research UK. Grant Number: C459/A2579
- Kyowa Hakko, Ltd
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- 2, , , , , , , Epidemiology of urinary bladder cancer: from tumor development to patientâs death, World Journal of Urology, 2007, 25, 3, 285
- 3, , , , , , Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia, Biochemical Pharmacology, 2007, 74, 6, 810
- 4, , NQO1-directed antitumour quinones, Expert Opinion on Therapeutic Patents, 2007, 17, 6, 649
- 5, , , , , , , , , , , , , , , , Phase I/II Pilot Study of Intravesical Apaziquone (EO9) for Superficial Bladder Cancer, The Journal of Urology, 2006, 176, 4, 1344
- 6, , , , , The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2, Bioorganic & Medicinal Chemistry, 2006, 14, 1, 263
- 7, , , , Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity, European Journal of Cancer, 2005, 41, 9, 1331
- 8, , Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2004, 555, 1-2, 149

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