Smoking and the risk of breast cancer among carriers of BRCA mutations
Article first published online: 27 FEB 2004
Copyright © 2004 Wiley-Liss, Inc.
International Journal of Cancer
Volume 110, Issue 3, pages 413–416, 20 June 2004
How to Cite
Ghadirian, P., Lubinski, J., Lynch, H., Neuhausen, S. L., Weber, B., Isaacs, C., Baruch, R.-G., Randall, S., Ainsworth, P., Freidman, E., Horsman, D., Tonin, P., Foulkes, W. D., Tung, N., Sun, P. and Narod, S. A. (2004), Smoking and the risk of breast cancer among carriers of BRCA mutations. Int. J. Cancer, 110: 413–416. doi: 10.1002/ijc.20106
- Issue published online: 12 APR 2004
- Article first published online: 27 FEB 2004
- Manuscript Accepted: 28 OCT 2003
- Manuscript Revised: 21 OCT 2003
- Manuscript Received: 10 FEB 2003
- Canadian Breast Cancer Research Initiative
- NCI. Grant Number: ROICA74415
- breast cancer
The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case-control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age-matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex-smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to l.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations. © 2004 Wiley-Liss, Inc.