Association of cigarette smoking with the risk of ovarian cancer

Authors

  • Sai Yi Pan,

    Corresponding author
    1. Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
    • Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, 120 Colonnade Road, Locator 6702A, Ottawa, Ontario, Canada K1A 0K9
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    • Fax: +1-613-941-2057

  • Anne-Marie Ugnat,

    1. Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
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  • Yang Mao,

    1. Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
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  • Shi Wu Wen,

    1. OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    2. Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
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  • Kenneth C. Johnson,

    1. Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
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  • The Canadian Cancer Registries Epidemiology Research Group

    1. Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
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  • The Canadian Cancer Registries Epidemiology Research Group is composed of the members listed above as well as a principal investigator from each of the provincial cancer registries involved in the National Enhanced Cancer Surveillance System: B. Paulse, M.Sc., B.N., Newfoundland Cancer Foundation; R. Dewar, M.A., Nova Scotia Cancer Registry; D. Dryer, M.D., Prince Edward Island Cancer Registry; N. Kreiger, Ph.D., Cancer Care Ontario; E. Kliewer, Ph.D., CancerCare Manitoba; D. Robson, B.A., Saskatchewan Cancer Foundation; S. Fincham, Ph.D., Division of Epidemiology, Prevention and Screening, Alberta Cancer Board; and N. Le, Ph.D., British Columbia Cancer Agency.

Abstract

Cigarette smoking may be associated with ovarian cancer risk. This association may differ by histological type. The authors conducted a population-based case-control study in Canada of 442 incident cases of ovarian cancer and 2,135 controls 20–76 years of age during 1994–1997 to examine this association, overall and by histological type. Compared to women who never smoked, those who smoked had higher odds (odds ratio [OR] = 1.22; 95% confidence interval [CI] = 0.98–1.53) of having ovarian cancer, and the OR was larger for ex-smokers (1.30; 95% CI = 1.01–1.67) than for current smokers (1.10; 95% CI = 0.81–1.49). The association with cigarette smoking was stronger for mucinous tumors (OR = 1.77; 95% CI = 1.06–2.96) than for nonmucinous tumors (OR = 1.13; 95% CI = 0.89–1.44). In addition, the odds of smokers having mucinous tumors increased with years of smoking (OR = 1.36, 1.88, 1.19, 4.89 for <20, 21–30, 31–40 and >40 years, respectively; p for trend = 0.002), number of cigarettes smoked per day (OR = 1.55, 1.89, 2.28 for <10, 11–20 and >20 cigarettes/day, respectively; p for trend = 0.014) and smoking pack-years (OR = 1.13, 2.65, 1.77 and 2.39 for <10, 11–20, 21–30 and >30 pack-years, respectively; p for trend = 0.004). Our data suggest that cigarette smoking is associated with an increased risk of ovarian cancer, especially for mucinous types. © 2004 Wiley-Liss, Inc.

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