Cancer Cell Biology
Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma
Article first published online: 20 MAY 2004
Copyright © 2004 Wiley-Liss, Inc.
International Journal of Cancer
Volume 111, Issue 6, pages 868–872, 10 October 2004
How to Cite
Dhar, D. K., Naora, H., Kubota, H., Maruyama, R., Yoshimura, H., Tonomoto, Y., Tachibana, M., Ono, T., Otani, H. and Nagasue, N. (2004), Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. Int. J. Cancer, 111: 868–872. doi: 10.1002/ijc.20357
- Issue published online: 3 AUG 2004
- Article first published online: 20 MAY 2004
- Manuscript Accepted: 18 MAR 2004
- Manuscript Received: 5 JAN 2004
- gastric adenocarcinoma;
- RNase protection assay
KiSS-1 is a promising candidate tumor-suppressor gene and may play a key role in the metastatic cascade. The expression profile and the role of KiSS-1 in cancer progression are largely unknown in most of the cancers, including gastric cancer. In this study, KiSS-1 expression was evaluated by RNase protection assay and localization was done by in situ hybridization in 40 gastric cancers and their adjacent normal gastric mucosa. For comparison with clinicopathologic characteristics and patient prognosis, all patients were divided into 2 groups having high and low KiSS-1 expression by using the median as the cutoff value of KiSS-1 expression as determined by the RNase protection assay. Gastric cancers with low KiSS-1 had frequent venous invasion, distant metastasis and tumor recurrence. Accordingly, patients with low KiSS-1-expressing tumors had a significantly worse overall and disease-free survival. In multivariate analysis, KiSS-1 became the strongest independent prognostic factor among the conventional prognosticators for gastric cancer patients. Collectively, these findings suggest that KiSS-1 may play a crucial role in gastric cancer invasion and could be a useful target for therapeutic intervention. © 2004 Wiley-Liss, Inc.