The first 2 authors contributed equally to this paper.
−93GA polymorphism of hMLH1 and risk of primary lung cancer
Version of Record online: 9 JUL 2004
Copyright © 2004 Wiley-Liss, Inc.
International Journal of Cancer
Volume 112, Issue 4, pages 678–682, 20 November 2004
How to Cite
Park, S. H., Lee, G. Y., Jeon, H.-S., Lee, S. J., Kim, K. M., Jang, S. S., Kim, C. H., Lee, W. K., Kam, S., Park, R. W., Kim, I.-S., Jung, T. H. and Park, J. Y. (2004), −93GA polymorphism of hMLH1 and risk of primary lung cancer. Int. J. Cancer, 112: 678–682. doi: 10.1002/ijc.20359
- Issue online: 13 SEP 2004
- Version of Record online: 9 JUL 2004
- Manuscript Accepted: 22 MAR 2004
- Manuscript Received: 31 OCT 2003
- National Cancer Control R&D Program 2003, Ministry of Health and Welfare, South Korea
- lung cancer;
- genetic susceptibility
Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking-related cancer. We investigated the association between the −93GA polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean population. The hMLH1 −93GA polymorphism was typed in 372 lung cancer patients and 371 healthy controls that were frequency-matched for age and sex. There was no significant association between the hMLH1 −93GA genotype and the risk for adenocarcinoma or small cell carcinoma. However, the AA genotype was associated with a significantly increased risk for squamous cell carcinoma compared with both the GG genotype (adjusted OR = 2.02; 95% CI = 1.15–3.55; p = 0.014) and the combined GG and GA genotype (adjusted OR = 1.83; 95% CI = 1.24–2.71; p = 0.003). When the subjects were stratified by smoking exposure, the AA genotype was associated with a significantly increased risk for squamous cell carcinoma in lighter smokers (≤ 39 pack-years; adjusted OR = 1.95; 95% CI = 1.03–3.66; p = 0.039) compared with the combined GG and GA genotype, whereas there was no significant association in heavier smokers (> 39 pack-years; adjusted OR = 1.47; 95% CI = 0.82–2.61). These results suggest that the hMLH1 −93GA polymorphism could be used as a marker of genetic susceptibility to squamous cell carcinoma of the lung. © 2004 Wiley-Liss, Inc.