• 1
    Petersen S, Heckert C, Rudolf J, Schluns K, Tchernitsa OI, Schafer R, Dietel M, Petersen I. Gene expression profiling of advanced lung cancer. Int J Cancer 2000; 86: 5127.
  • 2
    Difilippantonio S, Chen Y, Pietas A, Schluns K, Pacyna-Gengelbach M, Deutschmann N, Padilla-Nash HM, Ried T, Petersen I. Gene expression profiles in human non-small and small-cell lung cancers. Eur J Cancer 2003; 39: 193647.
  • 3
    Kumar NM, Gilula NB. The gap junction communication channel. Cell 1996; 84: 3818.
  • 4
    Kamibayashi Y, Oyamada Y, Mori M, Oyamada M. Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. Carcinogenesis 1995; 16: 128797.
  • 5
    tk;4Mesnil M, Krutovskikh V, Piccoli C, Elfgang C, Traub O, Willecke K, Yamasaki H. Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res 1995; 55: 62939.
  • 6
    Hirschi KK, Xu C, Tsukamoto T, Sager R. Cap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Diff 1996; 7: 86170.
  • 7
    Muramatsu A, Iwai M, Morikawa T, Tanaka S, Mori T, Harada Y, Okanoue T. Influence of transfection with connexin 26 gene on malignant potential of human hepatoma cells. Carcinogenesis 2002; 23: 3518.
  • 8
    Hellman P, Grummer R, Schirrmacher K, Rook M, Traub O, Winterhager E. Transfection with different connexin genes alters growth and differentiation of human choriocarcinoma cells. Exp Cell Res 1999; 246: 48090.
  • 9
    Kim DH, Kim JS, Ji YI, Shim YM, Kim H, Han J, Park J. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res 2003; 63: 37436.
  • 10
    Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 2001; 61: 24955.
  • 11
    Tan LW, Bianco T, Dobrovic A. Variable promoter region CpG island methylation of the putative tumor suppressor gene connexin 26 in breast cancer. Carcinogenesis 2002; 23: 2316.
  • 12
    Carson JL, Reed W, Moats-Staats BM, Brighton LE, Gambling TM, Hu SC, Collier AM. Connexin 26 expression in human and ferret airways and lung during development. Am J Respir Cell Mol Bio 1998; 18: 1119.
  • 13
    Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, Molloy PL, Paul CL. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 1992; 89: 182731.
  • 14
    SobinLH, WittekindCh, eds. TNM classification of malignant tumors, 5th ed. New York: Wiley-Liss, 1997. 227 p.
  • 15
    Richter J, Wagner U, Kononen J, Fijan A, Bruderer J, Schmid U, Ackermann D, Maurer R, Eland G, Knonagel H, Rist M, Wilber K, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 2000; 157: 78794.
  • 16
    Landberg G, Ostlund H, Nielsen NH, Roos G, Emdin S, Burger AM, Seth A. Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors. Oncogene 2001; 20: 3497505.
  • 17
    Yamasaki H, Mesnil M, Omori Y, Mironov N, Krutovskikh V. Intercellular communication and carcinogenesis. Mutat Res 1995; 333: 1818.
  • 18
    Mesnil M. Connexins and cancer. Biol Cell 2002; 94: 493500.
  • 19
    Lee SW, Tomasetto C, Sager R. Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci U S A 1991; 88: 28259.
  • 20
    Saito T, Nishimura M, Kudo R, Yamasaki H. Suppressed gap junctional intercellular communication in carcinogenesis of endometrium. Int J Cancer 2001; 93: 31723.
  • 21
    Bry C, Maass K, Miyoshi K, Willecke K, Ott T, Robinson GW, Hennighausen L. Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development. Dev Biol 2004; 267: 41829.
  • 22
    Fan SQ, Zhou M, Xiang Q, Wang JR, Xiong W, Wang R, Wei QY, Zhou JP, Li GY. In situ expression of connexins in various carcinomas. Ai Zheng 2003; 22: 68690.
  • 23
    Hotz-Wagenblatt A, Shalloway D. Gap junctional communication and neoplastic transformation. Crit Rev Oncog 1993; 4: 54158.
  • 24
    Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, Altman RB, Brown PO, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A 2001; 98: 137849.
  • 25
    Linjawi A, Kontogiannea M, Halwani F, Edwardes M, Meterissian S. Prognostic significance of p53, bcl-2, and Bax expression in early breast cancer. J Am Coll Surg 2004; 198: 8390.
  • 26
    Yeniyol CO, Suelozgen T, Vardar E, Sural S, Postaci H, Ayder AR. The relation of mutant p53 accumulation in transitional cell carcinoma of bladder with pathological stage, grade, recurrence and survival. Int Urol Nephrol 2001; 33: 4738.
  • 27
    Bennett WP, Colby TV, Travis WD, Borkowski A, Jones RT, Lane DP, Metcalf RA, Samet JM, Takeshima Y, Gu JR. p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res 1993; 53: 481722.
  • 28
    Cohen-Salmon M, Ott T, Michel V, Hardelin JP, Perfettini I, Eybalin M, Wu T, Marcus DC, Wangemann P, Willecke K, Petit C. Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol 2002; 12: 110611.
  • 29
    Piechocki MP, Burk RD, Ruch RJ. Regulation of connexin 32 and connexin 43 gene expression by DNA methylation in rat liver cells. Carcinogenesis 1999; 20: 4016.
  • 30
    King TJ, Fukushima LH, Hieber AD, Shimabukuro KA, Sakr WA, Bertram JS. Reduced levels of connexin 43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 2000; 21: 3115.
  • 31
    Loncarek J, Yamasaki H, Levillain P, Milinkevitch S, Mesnil M. The expression of the tumor suppressor gene connexin 26 is not mediated by methylation in human esophageal cancer cells. Mol Carcinog 2003; 36: 7481.
  • 32
    Soria JC, Lee HY, Lee JI, Wang L, Issa JP, Kemp BL, Liu DD, Kurie JM, Mao L, Khuri FR. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002; 8: 117884.
  • 33
    Stirzaker C, Millar DS, Paul CL, Warnecke PM, Harrison J, Vincent PC, Frommer M, Clark SJ. Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors. Cancer Res 1997; 57: 222937.
  • 34
    Dodge JE, List AF, Futscher BW. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia. Int J Cancer 1998; 78: 5617.
  • 35
    Satoh A, Toyota M, Itoh F, Sasaki Y, Suzuki H, Ogi K, Kikuchi T, Mita H, Yamashita T, Kojima T, Kusano M, Fujita M, et al. Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res 2003; 63: 860613.
  • 36
    Dong Y, Asch HL, Ying A, Asch BB. Molecular mechanism of transcriptional repression of gelsolin in human breast cancer cells. Exp Cell Res 2002; 276: 32836.