Epidemiology

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Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan

  1. Chien-Hung Lee1,
  2. Jang-Ming Lee2,
  3. Deng-Chyang Wu3,
  4. Hon-Ki Hsu4,
  5. Ein-Long Kao5,
  6. Hsiao-Ling Huang6,
  7. Tsu-Nai Wang1,
  8. Meng-Chuan Huang7,
  9. Ming-Tsang Wu8,†,*

Article first published online: 28 SEP 2004

DOI: 10.1002/ijc.20619

Issue

International Journal of Cancer

International Journal of Cancer

Volume 113, Issue 3, pages 475–482, 20 January 2005

Additional Information

How to Cite

Lee, C.-H., Lee, J.-M., Wu, D.-C., Hsu, H.-K., Kao, E.-L., Huang, H.-L., Wang, T.-N., Huang, M.-C. and Wu, M.-T. (2005), Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan. Int. J. Cancer, 113: 475–482. doi: 10.1002/ijc.20619

Author Information

  1. 1

    Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan

  2. 2

    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan

  3. 3

    Department of Gastroentology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

  4. 4

    Department of Chest Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

  5. 5

    Department of Chest Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

  6. 6

    Department of Community Health Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA

  7. 7

    Department of Public Health, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

  8. 8

    Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

  1. †

    Fax: +011886-7-3221806

*Graduate Institute of Occupational Health and Safety, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan

Publication History

  1. Issue published online: 18 NOV 2004
  2. Article first published online: 28 SEP 2004
  3. Manuscript Accepted: 13 JUL 2004
  4. Manuscript Received: 29 APR 2004

Funded by

  • Taiwan National Science Council. Grant Numbers: NSC 90-2320-B-037-040, NSC 90-2320-B-037-052
  • Taiwan National Health Research Institute. Grant Number: NHRI-CN-IN-9007P
  • Faculty Research Innovation Fund of Kaohsiung Medical University

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References

  • 1
    IARC. Tobacco smoking. IARC monographs on the evaluation of carcinogenic risks to humans. Tobacco smoking, vol 38. Lyon: IARC, 1986.
  • 2
    IARC. Alcohol drinking. IARC monographs on the evaluation of carcinogenic risks of chemicals to humans. Alcohol drinking, vol 44. Lyon: IARC, 1988.
  • 3
    Phukan RK, Ali MS, Chetia CK, Mahanta J. Betel nut and tobacco chewing; potential risk factors of cancer of esophagus in Assam, India. Br J Cancer 2001; 85: 661–7.
  • 4
    Wu MT, Lee YC, Chen CJ, Yang PW, Lee CJ, Wu DC, Hsu HK, Ho CK, Kao EL, Lee JM. Risk of betel chewing for oesophageal cancer in Taiwan. Br J Cancer 2001; 85: 658–60.
  • 5
    Boonyaphiphat P, Thongsuksai P, Sriplung H, Puttawibul P. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett 2002; 186: 193–9.
  • 6
    Department of Health. Executive Yuan, Republic Of China. Health statistics. vol. II Vital statistics: 1972–2002. Taipei, Department of Health, Executive Yuan, Taiwan, ROC, 2003.
  • 7
    Department of Health, Executive Yuan, Republic Of China. Cancer Registry Annual Report: 1991–2000. Taipei, Department of Health, Executive Yuan, Taiwan, ROC, 2000.
  • 8
    Ko YC, Chiang TA, Chang SJ, Hsieh SF. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. J Oral Pathol Med 1992; 21: 261–4.
    Direct Link:
  • 9
    Lee CH, Ko YC, Huang HL, Chao YY, Tsai CC, Shieh TY, Lin LM. The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan. Br J Cancer 2003; 88: 366–72.
  • 10
    Hosmer DW, Lemeshow S. Confidence interval estimation of interaction. Epidemiology 1992; 3: 452–6.
  • 11
    Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 1985; 122: 904–14.
  • 12
    Benichou J, Gail MH. Variance calculations and confidence intervals for estimates of the attributable risk based on logistic models. Biometrics 1990; 46: 991–1003.
  • 13
    Castellsagué X, Muñoz N, De Stefani E, Victora CG, Castelletto R, Rolón PA, Quintana MJ. Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer 1999; 82: 657–64.
    Direct Link:
  • 14
    Zambon P, Talamini R, La Vecchia C, Dal Maso L, Negri E, Tognazzo S, Simonato L, Franceschi S. Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy. Int J Cancer 2000; 86: 144–9.
    Direct Link:
  • 15
    Znaor A, Brennan P, Gajalakshmi V, Mathew A, Shanta V, Varghese C, Boffetta P. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer 2003; 105: 681–6.
    Direct Link:
  • 16
    Tavani A, Negri E, Franceschi S, La Vecchia C. Risk factors for esophageal cancer in lifelong nonsmokers. Cancer Epidemiol Biomarkers Prev 1994; 3: 387–92.
  • 17
    Cheng KK, Duffy SW, Day NE, Lam TH. Oesophageal cancer in never-smokers and never-drinkers. Int J Cancer 1995; 60: 820–2.
    Direct Link:
  • 18
    Tavani A, Negri E, Franceschi S, La Vecchia C. Tobacco and other risk factors for oesophageal cancer in alcohol non-drinkers. Eur J Cancer Prev 1996; 5: 313–8.
  • 19
    Yu MC, Garabrant DH, Peters JM, Mack TM. Tobacco, alcohol, diet, occupation, and carcinoma of the esophagus. Cancer Res 1988; 48: 3843–8.
  • 20
    Hu J, Nyren O, Wolk A, Bergstrom R, Yuen J, Adami HO, Guo, L. Li H, Huang G, Xu X. Risk factors for oesophageal cancer in northeast China. Int J Cancer 994; 57: 38–46.
    Direct Link:
  • 21
    Launoy G, Milan CH, Faivre J, Pienkowski P, Milan CI, Gignoux M. Alcohol, tobacco and oesophageal cancer: effects of the duration of consumption, mean intake and current and former consumption. Br J Cancer 1997; 75: 1389–96.
  • 22
    Bosetti C, Franceschi S, Levi F, Negri E, Talamini R, La Vecchia C. Smoking and drinking cessation and the risk of oesophageal cancer. Br J Cancer 2000; 83: 689–91.
  • 23
    Nandakumar A, Anantha N, Pattabhiraman V, Prabhakaran PS, Dhar M, Puttaswamy K, Venugopal TC, Reddy NM, Rajanna, Vinutha AT, Srinivas. Importance of anatomical subsite in correlating risk factors in cancer of the oesophagus—report of a case-control study. Br J Cancer 1996; 73: 1306–11.
  • 24
    Hoffmann D, Brunnemann KD, Prokopczyk B, Djordjevic MV. Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans. J Toxicol Environ Health 1994; 41: 1–52.
  • 25
    Sundqvist K, Liu Y, Nair J, Bartsch H, Arvidson K, Grafstrom RC. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res 1989; 49: 5294–8.
  • 26
    Ramchandani AG, D'Souza AV, Borges AM, Bhisey RA. Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus. Int J Cancer 1998; 75: 225–32.
    Direct Link:
  • 27
    Notani PN. Role of alcohol in cancers of the upper alimentary tract: use of models in risk assessment. J Epidemiol Community Health 1988; 42: 187–92.
  • 28
    Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995; 24: 450–3.
    Direct Link:
  • 29
    Lagergren J, Bergstrom R, Lindgren A, Nyren O. The role of tobacco, snuff and alcohol use in the etiology of cancer of the esophagus and gastric cardia. Int J Cancer 2000; 85: 340–6.
    Direct Link:
  • 30
    Farrow DC, Vaughan TL. Determinants of survival following the diagnosis of esophageal adenocarcinoma (United States). Cancer Causes Control 1996; 7: 322–7.
  • 31
    Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 2003; 95: 1404–13.
  • 32
    Negri E, La Vecchia C, Franceschi S, Decarli A, Bruzzi P. Attributable risks for oesophageal cancer in northern Italy. Eur J Cancer 1992; 28A: 1167–71.
  • 33
    Lee CH, Ko YC, Cheng LS, Lin YC, Lin HJ, Huang MS, Huang JJ, Kao EL, Wang HZ. The heterogeneity in risk factors of lung cancer and the difference of histologic distribution between genders in Taiwan. Cancer Causes Control 2001; 12: 289–300.
  • 34
    Wang LY, You SL, Lu SN, Ho HC, Wu MH, Sun CA, Yang HI, Chen CJ. Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan. Cancer Causes Control 2003; 14: 241–50.
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