Fax: +716-845-7608.
Early Detection and Diagnosis
You have full text access to this OnlineOpen article
Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics
Article first published online: 21 OCT 2004
DOI: 10.1002/ijc.20651
Copyright © 2004 Wiley-Liss, Inc.
Additional Information
How to Cite
Odunsi, K., Wollman, R. M., Ambrosone, C. B., Hutson, A., McCann, S. E., Tammela, J., Geisler, J. P., Miller, G., Sellers, T., Cliby, W., Qian, F., Keitz, B., Intengan, M., Lele, S. and Alderfer, J. L. (2005), Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics. Int. J. Cancer, 113: 782–788. doi: 10.1002/ijc.20651
Publication History
- Issue published online: 8 DEC 2004
- Article first published online: 21 OCT 2004
- Manuscript Accepted: 1 JUL 2004
- Manuscript Received: 24 OCT 2003
Funded by
- Cancer Research Institute/Ludwig Institute for Cancer Research Cancer Vaccine Collaborative Grant
- Roswell Park Cancer Center Support. Grant Number: P30CA16056
- NYSTAR faculty development grant
- NCI. Grant Number: KO7CA89123
- Abstract
- Article
- References
- Cited By
Cited in:
- CrossRef
This article has been cited by:
- 1, , , , , , , , Application of ex vivo 1H NMR metabonomics to the characterization and possible detection of renal cell carcinoma metastases, Journal of Cancer Research and Clinical Oncology, 2012, 138, 5, 753
- 2, , , , , , , , , , , , , Discrimination between malignant and benign ovarian tumors by plasma metabolomic profiling using ultra performance liquid chromatography/mass spectrometry, Clinica Chimica Acta, 2012, 413, 9-10, 861
- 3, , , , , , , , , , , Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by 1H nuclear magnetic resonance-based metabonomic profiles, Clinical Biochemistry, 2012,
- 4, , , , , , , , , , , , Identification of metabolic biomarkers to diagnose epithelial ovarian cancer using a UPLC/QTOF/MS platform, Acta Oncologica, 2012, 51, 4, 473
- 5, , Metabolic signatures of cancer unveiled by NMR spectroscopy of human biofluids, Progress in Nuclear Magnetic Resonance Spectroscopy, 2012, 62, 51
- 6, , Quantitative analysis in magnetic resonance spectroscopy: from metabolic profiling toin vivobiomarkers, Bioanalysis, 2012, 4, 3, 321
- 7
- 8, , , , , , Urinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy, Journal of Crohn's and Colitis, 2012,
- 9, , , , , , , , , A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy, Annals of Oncology, 2011, 23, 4, 860
- 10, , , An overview of biomarkers for the ovarian cancer diagnosis, European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011, 158, 2, 119
- 11, , , , , , , , , , , , Application of L-EDA in metabonomics data handling: global metabolite profiling and potential biomarker discovery of epithelial ovarian cancer prognosis, Metabolomics, 2011, 7, 4, 614
- 12
- 13, , , , , Clustering based on periodicity in high-throughput time course data, Statistical Analysis and Data Mining, 2011, 4, 6Direct Link:
- 14, , , , , , , , Descriptive review of current NMR-based metabolomic data analysis packages, Progress in Nuclear Magnetic Resonance Spectroscopy, 2011, 59, 3, 263
- 15, , , , , , , , , , , , , , , , , , , , , , , , , , , Human metabolic profiles are stably controlled by genetic and environmental variation, Molecular Systems Biology, 2011, 7,
- 16, , , , , , , , , , , , , , , Identification of a serum-detectable metabolomic fingerprint potentially correlated with the presence of micrometastatic disease in early breast cancer patients at varying risks of disease relapse by traditional prognostic methods, Annals of Oncology, 2011, 22, 6, 1295
- 17, , , , Metabolic signatures of malignant progression in prostate epithelial cells, The International Journal of Biochemistry & Cell Biology, 2011, 43, 7, 1002
- 18, , , , , , , , Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry, Journal of Gastroenterology and Hepatology, 2011, 26, 8Direct Link:
- 19, , , , , Metabolomics and surgical oncology: Potential role for small molecule biomarkers, Journal of Surgical Oncology, 2011, 103, 5Direct Link:
- 20, , , , Metabolomics for mitochondrial and cancer studies, Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011, 1807, 6, 650
- 21
- 22, , , , , , , Metabolomics study of esophageal adenocarcinoma, The Journal of Thoracic and Cardiovascular Surgery, 2011, 141, 2, 469
- 23, , , , , , , , , , , , , , , Serum 27-nor-5β-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer, Journal of Proteome Research, 2011, 10, 5, 2625
- 24, , , , , , , , Serum Metabolic Fingerprinting to Detect Human Nasopharyngeal Carcinoma Based on Gas Chromatography-Mass Spectrometry and Partial Least Squares-Linear Discriminant Analysis, Analytical Letters, 2011, 44, 8, 1473
- 25, , , , , Tumour xenograft detection through quantitative analysis of the metabolic profile of urine in mice, Physics in Medicine and Biology, 2011, 56, 3, 535
- 26
- 27, , , , , , A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer, International Journal of Cancer, 2010, 127, 12Direct Link:
- 28, , , , A sample preparation protocol for 1H nuclear magnetic resonance studies of water-soluble metabolites in blood and urine, Analytical Biochemistry, 2010, 398, 2, 263
- 29, , , Chemometrics in metabolomicsâA review in human disease diagnosis, Analytica Chimica Acta, 2010, 659, 1-2, 23
- 30, , , Comparison of analytical mathematical approaches for identifying key nuclear magnetic resonance spectroscopy biomarkers in the diagnosis and assessment of clinical change of diseases, The Journal of Comparative Neurology, 2010, 518, 20Direct Link:
- 31, , , , , , , , , , Effects of vitamin B12 on murine embryonic dexamethasone-induced cleft palates using 1H-NMR-based metabonomic analysis, Metabolomics, 2010, 6, 4, 467
- 32, , , , , , , , Gas chromatography/time-of-flight mass spectrometry-based metabonomics of hepatocarcinoma in rats with lung metastasis: elucidation of the metabolic characteristics of hepatocarcinoma at formation and metastasis, Rapid Communications in Mass Spectrometry, 2010, 24, 18Direct Link:
- 33, , , , , , , , Hepatitis C virus infection diagnosis using metabonomics, Journal of Viral Hepatitis, 2010, 17, 12Direct Link:
- 34, , , , , La métabolomique: un nouvel outil pour la recherche translationnelle en cancérologie, Oncologie, 2010, 12, 7, 409
- 35, , , , , La métabolomique: un nouvel outil pour la recherche translationnelle en cancérologie, Bio tribune magazine, 2010, 36, 1, 24
- 36, , , Metabolomics analysis II. Preparation of biological samples prior to detection, TrAC Trends in Analytical Chemistry, 2010, 29, 2, 120
- 37, , , Metabolomics in Toxicology: Preclinical and Clinical Applications, Toxicological Sciences, 2010, 120, Supplement 1, S146
- 38, , , , , , Metabonomics: A Useful Tool for the Future Surgeon, Journal of Surgical Research, 2010, 160, 1, 122
- 39, , , , , , , , , , NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats, Toxicology and Applied Pharmacology, 2010, 248, 3, 178
- 40, , , NMR-based metabonomics: a useful platform of oncology research, Bioanalytical Reviews, 2010, 1, 2-4, 117
- 41, , , , , , , Response to drug treatment in newly diagnosed epilepsy: A pilot study of 1H NMR- and MS-based metabonomic analysis, Epilepsy Research, 2010, 88, 2-3, 189
- 42, , , , , , , , , , Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups, Leukemia, 2010, 24, 4, 788
- 43, , , Statistical significance analysis of nuclear magnetic resonance-based metabonomics data, Analytical Biochemistry, 2010, 401, 1, 134
- 44, , , , The role of metabolites and metabolomics in clinically applicable biomarkers of disease, Archives of Toxicology, 2010, 85, 1, 5
- 45, , , Trend analysis of metabonomics and systematic review of metabonomics-derived cancer marker metabolites, Metabolomics, 2010, 7, 2, 155
- 46, , , , Understanding subfertility at a molecular level in the female through the application of nuclear magnetic resonance (NMR) spectroscopy, Human Reproduction Update, 2010, 17, 2, 228
- 47, , , , , , , , 1H NMR metabolomics study of age profiling in children, NMR in Biomedicine, 2009, 22, 8Direct Link:
- 48, , , , , , , , 1H NMR-based metabonomic and pattern recognition analysis for detection of oral squamous cell carcinoma, Clinica Chimica Acta, 2009, 401, 1-2, 8
- 49, , , , , Analytical and statistical approaches to metabolomics research, Journal of Separation Science, 2009, 32, 13Direct Link:
- 50, , , , , , , , , , , , Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity, Toxicological Sciences, 2009, 109, 2, 336
- 51, , , , Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?, Genes & Nutrition, 2009, 4, 2, 135
- 52, , , , , , , Metabolomics in the assessment of chemical-induced reproductive and developmental outcomes using non-invasive biological fluids: application to the study of butylbenzyl phthalate, Journal of Applied Toxicology, 2009, 29, 8Direct Link:
- 53, , Metabolomics tools for identifying biomarkers for neuropsychiatric diseases, Neurobiology of Disease, 2009, 35, 2, 165
- 54, , , , , Metabolomics: A New Frontier for Research in Pediatrics, The Journal of Pediatrics, 2009, 154, 5, 638
- 55
- 56
- 57, , , , The complex links between dietary phytochemicals and human health deciphered by metabolomics, Molecular Nutrition & Food Research, 2009, 53, 10Direct Link:
- 58, , Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer, Biomarkers in Medicine, 2009, 3, 3, 289
- 59, , , , , , 1H NMR-based metabonomic analysis of urine from young spontaneously hypertensive rats, Journal of Pharmaceutical and Biomedical Analysis, 2008, 46, 3, 550
- 60, , , , Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis, Acta Biotheoretica, 2008, 56, 3, 173
- 61, , , , , , Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats, Analytical Biochemistry, 2008, 383, 1, 76
- 62, Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics, Clinical Chemistry and Laboratory Medicine, 2008, 46, 1, 27
- 63, , , , , , , , , , Dynamic metabonomic analysis of BALB/C mice with different outcomes after D-galactosamine/lipopolysaccharide–induced fulminant hepatic failure, Liver Transplantation, 2008, 14, 11Direct Link:
- 64, , , , Metabolomic analysis of urine and serum in Parkinsonâs disease, Metabolomics, 2008, 4, 3, 191
- 65, , , , , , Metabolomics-based methods for early disease diagnostics, Expert Review of Molecular Diagnostics, 2008, 8, 5, 617
- 66, , , Metabolomics: A Global Biochemical Approach to Drug Response and Disease, Annual Review of Pharmacology and Toxicology, 2008, 48, 1, 653
- 67, , Metabolomics: A Global Biochemical Approach to the Study of Central Nervous System Diseases, Neuropsychopharmacology, 2008, 34, 1, 173
- 68, Recent development of metabonomics and its applica-tions in clinical research, Hereditas (Beijing), 2008, 30, 4, 389
- 69, , , , , , Use of EDTA to minimize ionic strength dependent frequency shifts in the 1H NMR spectra of urine, Metabolomics, 2008, 4, 4, 328
- 70, , , Use of genome-wide high-throughput technologies in biomarker development, Biomarkers in Medicine, 2008, 2, 5, 509
- 71, , , , , Visualization of Bile Homeostasis Using 1H-NMR Spectroscopy as a Route for Assessing Liver Cancer, Lipids, 2008, 44, 1, 27
- 72, Global metabolic profiling and its role in systems biology to advance personalized medicine in the 21st Century, Expert Review of Molecular Diagnostics, 2007, 7, 3, 247
- 73, , , , , , Mass spectrometry-based “omics” technologies in cancer diagnostics, Mass Spectrometry Reviews, 2007, 26, 3Direct Link:
- 74, , Metabolomic biomarkers: their role in the critical path, Drug Discovery Today: Technologies, 2007, 4, 1, 13
- 75, , , , , , , Metabolomic mapping of atypical antipsychotic effects in schizophrenia, Molecular Psychiatry, 2007, 12, 10, 934
- 76, , , Metabolomics as an Extension of Proteomic Analysis: Study of Acute Kidney Injury, Seminars in Nephrology, 2007, 27, 6, 609
- 77, Metabonomic technique and prospect of its application in integrated traditional Chinese and Western medicine research, Journal of Chinese Integrative Medicine, 2007, 475
- 78, , , Metabonomics in pharmaceutical R & D, FEBS Journal, 2007, 274, 5Direct Link:
- 79, , , , , Moving cancer diagnostics from bench to bedside, Trends in Biotechnology, 2007, 25, 4, 166
- 80, Potential role of body fluid1H NMR metabonomics as a prognostic and diagnostic tool, Expert Review of Molecular Diagnostics, 2007, 7, 6, 761
- 81, , , , , Recent advances in capillary electrophoresis for biomarker discovery, Journal of Separation Science, 2007, 30, 2Direct Link:
- 82, , , , A metabonomic analysis of plasma from Zucker rat strains using gas chromatography/mass spectrometry and pattern recognition, Rapid Communications in Mass Spectrometry, 2006, 20, 22Direct Link:
- 83, , , , , , , , A multi-analytical platform approach to the metabonomic analysis of plasma from normal and zucker (fa/fa) obese rats, Molecular BioSystems, 2006, 2, 3-4, 174
- 84, , Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics, Analytical and Bioanalytical Chemistry, 2006, 387, 2, 525
- 85, , , , , Detection of ovarian cancer using chemometric analysis of proteomic profiles, Chemometrics and Intelligent Laboratory Systems, 2006, 84, 1-2, 82
- 86, , , , , , , , Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum, Magnetic Resonance Materials in Physics, Biology and Medicine, 2006, 19, 6, 281
- 87, , , , , Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma, Metabolomics, 2006, 2, 3, 125
- 88, , , Metabonomics Techniques and Applications to Pharmaceutical Research & Development, Pharmaceutical Research, 2006, 23, 6, 1075
- 89, , , , , Molecular predictors of response and outcome in ovarian cancer, Critical Reviews in Oncology/Hematology, 2006, 60, 1, 19
- 90, , Monitoring the health to disease continuum with global metabolic profiling and systems biology, Pharmacogenomics, 2006, 7, 7, 1077
- 91, , Pattern recognition and biomarker validation using quantitative1H-NMR-based metabolomics, Expert Review of Molecular Diagnostics, 2006, 6, 5, 717
- 92, , , Progress in capillary electrophoresis of biomarkers and metabolites between 2002 and 2005, ELECTROPHORESIS, 2006, 27, 1Direct Link:
- 93, , , , , , , Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics, Metabolomics, 2006, 2, 4, 257
- 94, , , The application of NMR-based metabonomics in neurological disorders, Neurotherapeutics, 2006, 3, 3, 358
- 95, , , The application of NMR-based metabonomics in neurological disorders, NeuroRX, 2006, 3, 3, 358
- 96, , , , , , , The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2006, 20, 19Direct Link:
- 97, , , 1H-NMR metabonomics analysis of sera differentiates between mammary tumor-bearing mice and healthy controls, Metabolomics, 2005, 1, 3, 269
- 98Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential?,Direct Link:
- 99, Metabolic Profiling for Biomarker Discovery,Direct Link:
- 100, , , NMR-Based Metabolomics Technology in Biomarker Research, Wiley Encyclopedia of Chemical Biology,Direct Link:
- 101, , , , Targeted Metabolomics, Current Protocols in Molecular Biology,Direct Link:

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
