Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer
Article first published online: 18 NOV 2004
Copyright © 2004 Wiley-Liss, Inc.
International Journal of Cancer
Volume 114, Issue 3, pages 465–471, 10 April 2005
How to Cite
Chang, Y.-W., Jang, J.-Y., Kim, N.-H., Lee, J. W., Lee, H. J., Jung, W. W., Dong, S.-H., Kim, H.-J., Kim, B.-H., Lee, J.-I. and Chang, R. (2005), Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer. Int. J. Cancer, 114: 465–471. doi: 10.1002/ijc.20724
- Issue published online: 8 FEB 2005
- Article first published online: 18 NOV 2004
- Manuscript Accepted: 13 SEP 2004
- Manuscript Received: 1 JUN 2004
- gastric cancer;
- interleukin-1 polymorphisms;
- IL-1β mucosal level
Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1β and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1β cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR = 2.2; 95% CI = 1.1–4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR = 3.4; 95% CI = 1.5–7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1β levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1β production contributed to the development of intestinal-type GC in this Korean population. © 2004 Wiley-Liss, Inc.