• 1
    Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H. The protein Id: a negative regulator of the helix-loop-helix DNA binding proteins. Cell 1990; 61: 4959.
  • 2
    Parrinello S, Lin CQ, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez P-Y. Id-1,ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis. J Biol Chem 2001; 276: 3921319.
  • 3
    Mori S, Nishikawa S-I, Yokota Y. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2. EMBO J 2000; 19: 577281.
  • 4
    Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Id1 and Id3 are required for neurogenesis,angiogenesis and vascularization of tumour xenografts. Nature 1999; 401: 6707.
  • 5
    Maruyama H, Kleeff J, Wildi S, Friess H, Buchler MW, Israel MA, Korc M. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am J Pathol 1999; 155: 81522.
  • 6
    Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, Desprez P-Y. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000; 60: 133240.
  • 7
    Wilson JW, Deed RW, Inoue T, Balzi M, Becciolini A, Faraoni P, Potten CS, Norton JD. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res 2001; 61: 880310.
  • 8
    Itahana Y, Singh J, Sumida T, Coppe J-P, Parrinello S, Bennington JL, Desprez P-Y. Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells. Cancer Res 2003; 63: 7098105.
  • 9
    Coppe J-P, Itahana Y, Moore DH, Bennington JL, Desprez P-Y. Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res 2004; 10: 204451.
  • 10
    Schoppmann SF, Schindl M, Bayer G, Aumayr K, Dienes J, Horvat R, Rudas M, Gnant M, Jakesz R, Birner P. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int J Cancer 2003; 104: 67782.
  • 11
    Sun X. Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 1994; 79: 893900.
  • 12
    Barone M, Pepperkok R, Peverali F, Philipson L. Id proteins control growth induction in mammalian cells. Proc Natl Acad Sci USA 1994; 91: 49858.
  • 13
    Iavarone A, Garg P, Lasorella A, Hsu J, Israel MA. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev 1994; 8: 127084.
  • 14
    Lasorella A, Iavarone A, Israel M. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol 1996; 16: 25708.
  • 15
    Liu Y, Encinas M, Comella JX, Aldea M, Gallego C. Basic helix-loop-helix proteins bind to TrkB and p21Cip1 promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Mol Cell Biol 2004; 24: 266272.
  • 16
    Prabhu S, Ignatova A, Park S, Sun X. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol Cell Biol 1997; 17: 588896.
  • 17
    Hara E, Hall M, Peters G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J 1997; 16: 33242.
  • 18
    Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 2000; 407: 5918.
  • 19
    Lee EY, Hu N, Yuan SS, Cox LA, Bradley A, Lee WH, Herrup K. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev 1994; 8: 200821.
  • 20
    Zacksenhaus E, Jiang Z, Chung D, Marth JD, Philips RA, Gallie BL. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 1996; 10: 305164.
  • 21
    Toma JG, El-Bizri H, Barnabe-Heider F, Aloyz R, Miller FD. Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppressor protein to regulate cortical neurogenesis. J Neurosci 2000; 20: 764856.
  • 22
    Nielsen NH, Arnelov C, Emdin SO, Landberg G. Cyclin E over- expression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status. Br J Cancer 1996; 74: 87480.
  • 23
    Jogi A, Persson P, Grynfeld A, Pahlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem 2002; 277: 911826.
  • 24
    Miyoshi K, Meyer B, Gruss P, Cui Y, Renou J-P, Morgan FV, Smith GH, Reichenstein M, Shani M, Hennighausen L, Robinson GW. Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol Endocrinol 2002; 16: 2892901.
  • 25
    Schaafsma HE, Ramaekers FC. Cytokeratin subtyping in normal and neoplastic epithelium: basic principles and diagnostic applications. Pathol Annu 1994; 29: 2162.
  • 26
    Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J,et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10: 536774.
  • 27
    Abd El-Rehim DM, Pinder SE, Paish CE, Bell J, Blamey RW, Robertson JF, Nicholson RI, Ellis IO. Expression of luminal and basal cytokeratins in human breast carcinoma. J Pathol 2004; 203: 66171.
  • 28
    Toth T. Cytokeratins 7 and 14 in special types of invasive breast carcinomas. Med Pregl 1999; 52: 22732.
  • 29
    Deed RW, Armitage S, Norton JD. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J Biol Chem 1996; 271: 236036.
  • 30
    O'Toole PJ, Inoue T, Emerson L, Morrison IEG, Mackie AR, Cherry RJ, Norton JD. Id proteins negatively regulate basic helix-loop-helix transcription factor function by disrupting subnuclear compartmentalization. J Biol Chem 2003; 278: 457706.
  • 31
    Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 40310.