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Cancer Cell Biology
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Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells
Article first published online: 18 FEB 2005
DOI: 10.1002/ijc.20972
Copyright © 2005 Wiley-Liss, Inc.
Additional Information
How to Cite
Erdal, E., Ozturk, N., Cagatay, T., Eksioglu-Demiralp, E. and Ozturk, M. (2005), Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int. J. Cancer, 115: 903–910. doi: 10.1002/ijc.20972
Publication History
- Issue published online: 12 MAY 2005
- Article first published online: 18 FEB 2005
- Manuscript Accepted: 16 NOV 2004
- Manuscript Received: 22 SEP 2004
Funded by
- TUBITAK
- Turkish Association for Research and Fight against Cancer
- Bilkent University and Turkish Academy of Sciences (TUBA)
References
- 1, . Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge. Am J Psychiatry 1999; 156: 1506–14.
- 2, . The legacy of lithium effects on development. Biol Cell 1998; 90: 585–9.
- 3, . Induction of early stages of kidney tubule differentiation by lithium ions. Dev Biol 1995; 167: 50–60.
- 4, , , , , . Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol 1997; 185: 82–91.
- 5, , , . Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. Development 1999; 126: 345–57.
- 6, , , . TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis. Dev Biol 2000; 217: 230–43.
- 7, . A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996; 93: 8455–9.
- 8, , , . Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodeling induced by WNT-7a or lithium. J Cell Sci 1998; 111: 1351–61.
- 9, , . Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 1996; 6: 1664–8.
- 10, . Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 1999; 11: 233–40.
- 11, . Catenins, Wnt signaling and cancer. Bioessays 2000; 22: 961–5.Direct Link:
- 12, , , , , , , . Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC −/− colon carcinoma. Science 1997; 275: 1784–7.
- 13, , . The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 1999; 19: 5576–87.
- 14, . Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422–6.
- 15, , , , , , , , . Identification of c-MYC as a target of the APC pathway. Science 1998; 281: 1509–12.
- 16, , , . No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas. Cancer Res 1996; 56: 49–52.
- 17, , , , . Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 1999; 154: 325–9.
- 18, , , , , , , . Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol 2001; 152: 87–96.
- 19, , , . Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. Eur J Cancer 2000; 36: 242–8.
- 20, , , , , , , . Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 2000; 97: 4262–6.
- 21, , , , , , , , , , , , et al. Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma. J Pathol 2001; 193: 483–90.Direct Link:
- 22, , , , , , , . Cytoplasmic/nuclear expression without mutation of exon 3 of the beta-catenin gene is frequent in the development of the neoplasm of the uterine cervix. Gynecol Oncol 2001; 82: 450–5.
- 23, , , , , , , . Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas. Br J Cancer 2000; 85: 64–8.
- 24, , , , , , , , , . Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas. Cancer 2002; 94: 752–8.Direct Link:
- 25, , , , , , , . Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res 2002; 8: 450–6.
- 26, . Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–70.
- 27, , , , , . Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. Cancer Res 1999; 59: 269–73.
- 28, , , , , . Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas. Oncogene 2000; 19: 498–504.
- 29, , , , , . Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000; 157: 763–70.
- 30, , , , , , . CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinog 2001; 31: 68–73.Direct Link:
- 31, , . beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001; 92: 136–45.Direct Link:
- 32, , , , , , , , , , , , et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000; 24: 245–50.
- 33, , , , , , , , , . Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001; 120: 1763–73.
- 34, , , , , , , , , , , . Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002; 21: 4863–71.
- 35, . P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. Oncogene 2002; 21: 7971–80.
- 36, , , , . Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem 2003; 278: 33067–77.
- 37, , , . NAPO as a novel marker for apoptosis. J Cell Biol 2001; 155: 719–724.
- 38. Recycling the cell cycle: cyclins revisited. Cell 2004; 116: 221–34.
- 39, , , , . Liver tumors escape negative control of proliferation via PI3K/Akt mediated block of C/EBPAα growth inhibitor activity. Genes Dev 2004; 18: 912–25.
- 40, . Cell cycle and death control: long live forkheads. Trends Biochem Sci 2002; 27: 352–60.
- 41, . PTEN: from pathology to biology. Trends Cell Biol 2003; 13: 478–83.
- 42, , , , , , , , , , , , et al. Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence. Hepatology 1999; 30: 90–9.Direct Link:
- 43, , , , , , , , , , , . Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis. Hepatology 2003; 37: 534–43.Direct Link:
- 44, , , . Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res 2003; 63: 3593–7.
- 45, . The multifaceted roles of glycogen synthase kinase 3b in cellular signaling. Prog Neurobiol 2001; 65: 391–426.
- 46, , , . Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998; 12: 3499–511.
- 47, . PKB/Akt: a key mediator of cell proliferation, survival and insulin responses. J Cell Sci 2001; 114: 2903–10.
- 48, , , , , , . C/EBPa arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 2001; 8: 817–28.
- 49, , . Aging reduces proliferative capacities of liver by switching pathways of C/EBPA growth arrest. Cell 2003; 113: 495–506.
- 50, , , , . Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene 2004; 23: 4624–35.
- 51, , , . Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene 2001; 20: 5111–7.