Case-control study of familial lung cancer risks in UK women

Authors

  • Athena Matakidou,

    Corresponding author
    1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    2. Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
    • Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, 15 Cotswold Road; Sutton, Surrey, SM2 5NG, United Kingdom
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    • Fax: +44-0-208-722-4359.

  • Tim Eisen,

    1. Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
    2. Lung Unit, Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
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    • Tim Eisen and Richard S. Houlston shared senior authorship.

  • Helen Bridle,

    1. Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
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  • Mary O'Brien,

    1. Lung Unit, Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
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  • Rosalind Mutch,

    1. Section of Medicine, Royal Marsden Hospital, Downs Road, Sutton, United Kingdom
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  • Richard S. Houlston,

    1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
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    • Tim Eisen and Richard S. Houlston shared senior authorship.

  • Members of the GELCAPS Consortium

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    • List of collaborators of the GELCAPS Consortium available on request.


Abstract

Family history data from a case-control study of lung cancer conducted in the United Kingdom between 1999 and 2004 were analysed to estimate familial risks of the disease. Comparison of lung cancer prevalence in first-degree relatives of 1,482 female lung cancer cases and 1,079 female controls was undertaken using logistic regression adjusting for age and tobacco exposure. Overall, lung cancer in a first-degree relative was associated with a significant increase in the risk of lung cancer [odds ratio (OR) 1.49; 95% confidence interval (CI), 1.13–1.96]. For cases with early onset of the disease (< 60 years), the OR of lung cancer was 2.02 (95% CI, 1.22–3.34). Having 2 or more affected relatives was associated with an OR of 2.68 (95% CI, 1.29–5.55), with a significant trend in risk according to the number of relatives affected (p = 0.001). An increased risk of lung cancer associated with family history of the disease was observed when analysis was restricted to lifetime nonsmokers, although this did not reach significance (OR 1.23; 95% CI, 0.65–2.31). Results confirm previous findings and support the role of a familial predisposition to lung cancer. © 2005 Wiley-Liss, Inc.

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