Epidemiology

You have full text access to this OnlineOpen article

Dietary acrylamide and human cancer

  1. Claudio Pelucchi1,†,*,
  2. Carlotta Galeone1,
  3. Fabio Levi2,
  4. Eva Negri1,
  5. Silvia Franceschi3,
  6. Renato Talamini4,
  7. Cristina Bosetti1,
  8. Attilio Giacosa5,
  9. Carlo La Vecchia1,6

Article first published online: 7 JUL 2005

DOI: 10.1002/ijc.21336

Issue

International Journal of Cancer

International Journal of Cancer

Volume 118, Issue 2, pages 467–471, 15 January 2006

Additional Information

How to Cite

Pelucchi, C., Galeone, C., Levi, F., Negri, E., Franceschi, S., Talamini, R., Bosetti, C., Giacosa, A. and La Vecchia, C. (2006), Dietary acrylamide and human cancer. Int. J. Cancer, 118: 467–471. doi: 10.1002/ijc.21336

Author Information

  1. 1

    Istituto di Ricerche Farmacologiche “Mario Negri,” Milano, Italy

  2. 2

    Institut Universitaire de Médecine Sociale et Préventive, Lausanne, Switzerland

  3. 3

    International Agency for Research on Cancer, Lyon, France

  4. 4

    Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Italy

  5. 5

    Gastroenterology and Nutrition Unit, National Cancer Research Institute, Genoa, Italy

  6. 6

    Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

  1. †

    Fax +39-02-33200231.

*Istituto di Ricerche Farmacologiche “Mario Negri,” Via Eritrea, 62, 20157 Milano, Italy

Publication History

  1. Issue published online: 9 NOV 2005
  2. Article first published online: 7 JUL 2005
  3. Manuscript Accepted: 20 MAY 2005
  4. Manuscript Received: 21 MAR 2005

Funded by

  • Italian Association for Cancer Research
  • Italian and Swiss Leagues against Cancer
  • Italian Ministry of Education. Grant Number: COFIN 2003
  • Italian Foundation for Cancer Research

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (82K)

References

  • 1
    IARC. Monographs on the evaluation of carcinogenic risks to humans. Some industrial chemicals. vol. 60. Lyon: IARC, 1994.
  • 2
    Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, Mast RW. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 1986; 85: 154–68.
  • 3
    Besaratinia A, Pfeifer GP. Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst 2004; 96: 1023–9.
  • 4
    Tareke E, Rydberg P, Karlsson P, Eriksson S, Tornqvist M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 2002; 50: 4998–5006.
  • 5
    Weiss G. Cancer risks: acrylamide in food—uncharted territory. Science 2002; 297: 27.
  • 6
    World Health Organization. FAO/WHO consultation on the health implications of acrylamide in food: summary report of a meeting held in Geneva, 25–27 June 2002. Geneva: World Health Organization, 2002.
  • 7
    Svensson K, Abramsson L, Becker W, Glynn A, Hellenas KE, Lind Y, Rosen J. Dietary intake of acrylamide in Sweden. Food Chem Toxicol 2003; 41: 1581–6.
  • 8
    Konings EJ, Baars AJ, van Klaveren JD, Spanjer MC, Rensen PM, Hiemstra M, van Kooij JA, Peters PWJ. Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 2003; 41: 1569–79.
  • 9
    Agence Française de Sécurité Sanitaire des Aliments. Acrylamide: point d'information n°2. Maisons-Alfort: Agence Française de Sécurité Sanitaire des Aliments, 2003.
  • 10
    Food and Drug Administration. Exploratory data on acrylamide in food: FY 2003 total diet study results. Bethesda, MD: Food and Drug Administration, 2004.
  • 11
    Murkovic M. Acrylamide in Austrian foods. J Biochem Biophys Methods 2004; 61: 161–7.
  • 12
    FAO/WHO. Summary and conclusions of the sixty-fourth meeting of the joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva: FAO/WHO, 2005.
  • 13
    Swiss Federal Office of Public Health. Assessment of acrylamide intake by duplicate diet study. Bern: Swiss Federal Office of Public Health, 2002.
  • 14
    Dybing E, Sanner T. Risk assessment of acrylamide in foods. Toxicol Sci 2003; 75: 7–15.
  • 15
    Matthys C, Bilau M, Govaert Y, Moons E, De Henauw S, Willems JL. Risk assessment of dietary acrylamide intake in Flemish adolescents. Food Chem Toxicol 2005; 43: 271–8.
  • 16
    Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SPD, Muller DJG, Olin S, Petersen BJ, Schlatter J, Scholz G, Scimeca JA, Slimani N, et al. Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 2005; 43: 365–410.
  • 17
    Marsh GM, Lucas LJ, Youk AO, Schall LC. Mortality patterns among workers exposed to acrylamide: 1994 follow up. Occup Environ Med 1999; 56: 181–90.
  • 18
    Sobel W, Bond GG, Parsons TW, Brenner FE. Acrylamide cohort mortality study. Br J Ind Med 1986; 43: 785–8.
  • 19
    Mucci LA, Sandin S, Balter K, Adami HO, Magnusson C, Weiderpass E. Acrylamide intake and breast cancer risk in Swedish women. JAMA 2005; 293: 1326–7.
  • 20
    Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer 2003; 88: 84–9.
  • 21
    Mucci LA, Lindblad P, Steineck G, Adami HO. Dietary acrylamide and risk of renal cell cancer. Int J Cancer 2004; 109: 774–6.
    Direct Link:
  • 22
    Pelucchi C, Franceschi S, Levi F, Trichopoulos D, Bosetti C, Negri E, La Vecchia C. Fried potatoes and human cancer. Int J Cancer 2003; 105: 558–60.
    Direct Link:
  • 23
    Pelucchi C, La Vecchia C, Franceschi S, Levi F. Fried potatoes and human cancer. Int J Cancer 2004; 108: 636–7.
    Direct Link:
  • 24
    Soler M, Bosetti C, Franceschi S, Negri E, Zambon P, Talamini R, Conti E, La Vecchia C. Fiber intake and the risk of oral, pharyngeal and esophageal cancer. Int J Cancer 2001; 91: 283–7.
    Direct Link:
  • 25
    Levi F, Pasche C, Lucchini F, Chatenoud L, Jacobs DRJr, La Vecchia C. Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer. Eur J Clin Nutr 2000; 54: 487–9.
  • 26
    La Vecchia C, Braga C, Negri E, Franceschi S, Russo A, Conti E, Falcini F, Giacosa A, Montella M, Decarli A. Intake of selected micronutrients and the risk of colorectal cancer. Int J Cancer 1997; 73: 525–30.
    Direct Link:
  • 27
    Levi F, Pasche C, La Vecchia C, Lucchini F, Franceschi S. Food groups and colorectal cancer risk. Br J Cancer 1999; 79: 1283–7.
  • 28
    Franceschi S, Favero A, Decarli A, Negri E, La Vecchia C, Ferraroni M, Russo A, Salvini S, Amadori D, Conti E, Montella M, Giacosa A. Intake of macronutrients and the risk of breast cancer. Lancet 1996; 347: 1351–6.
  • 29
    Levi F, La Vecchia C, Gulie C, Negri E. Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer 1993; 19: 327–35.
  • 30
    Bosetti C, Micelotta S, Dal Maso L, Talamini R, Montella M, Negri E, Conti E, Franceschi S, La Vecchia C. Food groups and risk of prostate cancer in Italy. Int J Cancer 2004; 110: 424–8.
    Direct Link:
  • 31
    Franceschi S, Negri E, Salvini S, Decarli A, Ferraroni M, Filiberti R, Giacosa A, Talamini R, Nanni O, Panarello G, La Vecchia C. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items. Eur J Cancer 1993; 29A: 2298–305.
  • 32
    Decarli A, Franceschi S, Ferraroni M, Gnagnarella P, Parpinel MT, La Vecchia C, Negri E, Salvini S, Falcini F, Giacosa A. Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy: results for specific nutrients. Ann Epidemiol 1996; 6: 110–8.
  • 33
    Franceschi S, Barbone F, Negri E, Decarli A, Ferraroni M, Filiberti R, Giacosa A, Gnagnarella P, Nanni O, Salvini S, La Vecchia C. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific nutrients. Ann Epidemiol 1995; 5: 69–75.
  • 34
    Breslow NE, Day NE. Statistical methods in cancer research: the analysis of case-control studies. vol. 1. Lyon: IARC, 1980.
  • 35
    Kroes R, Muller D, Lambe J, Lowik MR, van Klaveren J, Kleiner J, Massey R, Mayer S, Urieta I, Verger P, Visconti A. Assessment of intake from the diet. Food Chem Toxicol 2002; 40: 327–85.
  • 36
    D'Avanzo B, La Vecchia C, Katsouyanni K, Negri E, Trichopoulos D. An assessment, and reproducibility of food frequency data provide by hospital controls. Eur J Cancer Prev 1997; 6: 288–93.
  • 37
    Willett WC, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17–27.
  • 38
    Decarli A, Favero A, La Vecchia C, Russo A, Ferraroni M, Negri E, Franceschi S. Macronutrients, energy intake, and breast cancer risk: implications from different models. Epidemiology 1997; 8: 425–8.
  • 39
    Kipnis V, Midthune D, Freedman LS, Bingham S, Schatzkin A, Subar A, Carroll RJ. Empirical evidence of correlated biases in dietary assessment instruments and its implications. Am J Epidemiol 2001; 153: 394–403.
  • 40
    Schatzkin A, Kipnis V. Could exposure assessment problems give us wrong answers to nutrition and cancer questions? J Natl Cancer Inst 2004; 96: 1564–5.
  • 41
    Kipnis V, Subar AF, Midthune D, Freedman LS, Ballard-Barbash R, Troiano RP, Bingham S, Schoeller DA, Schatzkin A, Carroll RJ. Structure of dietary measurement error: results of the OPEN biomarker study. Am J Epidemiol 2003; 158: 14–21.
  • 42
    Bingham SA, Luben R, Welch A, Wareham N, Khaw KT, Day N. Are imprecise methods obscuring a relation between fat and breast cancer? Lancet 2003; 362: 212–4.
  • 43
    Granath F, Tornqvist M. Who knows whether acrylamide in food is hazardous to humans? J Natl Cancer Inst 2003; 95: 842–3.
  • 44
    Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K. Dietary acrylamide and cancer risk: additional data on coffee. Br J Cancer 2003; 89: 775–6.
  • 45
    Erdreich LS, Friedman MA. Epidemiologic evidence for assessing the carcinogenicity of acrylamide. Regul Toxicol Pharm 2004; 39: 150–7.
  • 46
    Hagmar L, Tornqvist M. Inconclusive results from an epidemiological study on dietary acrylamide and cancer. Br J Cancer 2003; 89: 774–6.
View Full Article (HTML) Get PDF (82K)