Innate immune recognition of nucleic acids: Beyond toll-like receptors
Version of Record online: 3 AUG 2005
Copyright © 2005 Wiley-Liss, Inc.
International Journal of Cancer
Volume 117, Issue 4, pages 517–523, 20 November 2005
How to Cite
Ishii, K. J. and Akira, S. (2005), Innate immune recognition of nucleic acids: Beyond toll-like receptors. Int. J. Cancer, 117: 517–523. doi: 10.1002/ijc.21402
- Issue online: 14 SEP 2005
- Version of Record online: 3 AUG 2005
- Manuscript Accepted: 17 JUN 2005
- Manuscript Received: 22 MAY 2005
- Innate immunity;
- CpG motif;
During infection or tissue damage, the innate immune system detects and responds to nucleic acids released from pathogens or damaged host cells. Accumulating evidence has showed that specific sequences, modifications or structures of nucleic acids influence their immunomodulatory activities. Resulting innate immune modulations are regulated by Toll-like receptor (TLR)-dependent or -independent signaling pathways. The first step in host defense against foreign or unwelcome self nucleic acids may play important roles in immune responses against infectious organisms, as well as in clearance of unnecessary tissues, which may be linked to autoimmune diseases and possibly to other immunological disorders. Elucidating mechanisms of innate immune activation by nucleic acids will help future development of more efficient or safer nucleic acid-based immunotherapies and gene therapies. © 2005 Wiley-Liss, Inc.