• 1
    Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 53343.
  • 2
    Duffy MJ. Predictive markers in breast and other cancers: a review. Clin Chem 2005; 51: 494503
  • 3
    Evans B, Griffiths K, Morton M. Inhibition of 5 α-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol 1995; 147: 295302.
  • 4
    Kuiper G, Lemmen J, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 425263.
  • 5
    Limer JL, Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res 2004; 6: 11927.
  • 6
    Gollschewski S, Anderson D, Skerman H, Lyons-Wall P. The use of complementary and alternative medications by menopausal women in South East Queensland. Womens Health Issues 2004; 14: 16571.
  • 7
    Thompson LU. Flaxseed, lignans, and cancer. In: Thompson LU, Cunanne S, eds. Flaxseed in human nutrition, 2nd ed. Illinois: AOCS Press, 2004. 194222.
  • 8
    Jacobs E, Kulling SE, Metzler M. Novel metabolites of the mammalian lignans enterolactone and enterodiol in human urine. J Steroid Biochem Mol Biol 1999; 68: 2118.
  • 9
    Turner NJ, Thomson BM, Shaw IC. Bioactive isoflavones in functional foods: the importance of gut microflora on bioavailability. Nutr Rev 2003; 61: 20413.
  • 10
    Adlercreutz H. Phytoestrogens and breast cancer. J Steroid Biochem Mol Biol 2002; 83: 1138.
  • 11
    Thompson L, Rickard S, Orcheson L, Seidl M. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 1996; 17: 13736.
  • 12
    Saarinen NM, Warri A, Makela SI, Eckerman C, Reunanen M, Ahotupa M, Salmi SM, Franke AA, Kangas L, Santti R. Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies). Nutr Cancer 2000; 36: 20716.
  • 13
    Saarinen N, Huovinen R, Warri A, Makela SI, Valentin-Blasini L, Sjoholm R, Ammala J, Lehtila R, Eckerman C, Collan YU, Santti RS. Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat. Mol Cancer Ther 2002; 1: 86976.
  • 14
    Chen J, Hui E, Ip T, Thompson L. Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen dependent human breast cancer (MCF-7) in nude mice. Clin Cancer Res 2004; 10: 770311.
  • 15
    Wang C, Kurzer MS. Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors. Nutr Cancer 1998; 31: 90100.
  • 16
    Wang C, Kurzer MS. Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 1997; 28: 23647.
  • 17
    Ju Y, Allred C, Allred K, Karko KL, Doerge DR, Helferich WG. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001; 131: 295762.
  • 18
    Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993; 123: 193951.
  • 19
    Allred C, Allred K, Ju Y, Virant SM, Helferich WG. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res 2001; 61: 504550.
  • 20
    Sathyamoorthy N, Wang TT, Phang JM. Stimulation of pS2 expression by diet-derived compounds. Cancer Res 1994; 54: 95761.
  • 21
    Welshons WV, Murphy CS, Koch R, Calaf G, Jordan VC. Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast Cancer Res Treat 1987; 10: 16975.
  • 22
    Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992; 41: 6159.
  • 23
    Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERα) and ERβ in human cells. Toxicol Sci 2004; 80: 1425.
  • 24
    Adlercreutz H, Bannwart C, Wahala K, Makela T, Brunow G, Hase T, Arosemena PJ, Kellis JT,Jr., Vickery LE. Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 1993; 44: 14753.
  • 25
    Li X, Nokkala E, Yan W, Streng T, Saarinen N, Warri A, Huhtaniemi I, Santti R, Makela S, Poutanen M. Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase. Endocrinology 2001; 142: 243542.
  • 26
    Saarinen N, Makela S, Santti R. Mechanism of anticancer effects of lignans with a special emphasis on breast cancer. In: Thompson LU, Cunanne S, eds. Flaxseed in human nutrition, 2nd ed. Illinois: AOCS Press, 2004. 22331
  • 27
    Brooks JD, Thompson LU. Mammalian lignans and genistein decreases the activity of aromatase and 17β-hydroxysteroid dehydrogenase in MCF-7 cells. J Steroid Biochem Mol Biol 2005; 94: 4617.
  • 28
    Qu H, Madl RL, Takemoto DJ, Baybutt RC, Wang W. Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells. J Nutr 2005; 135: 598602.
  • 29
    Bylund A, Saarinen N, Zhang JX, Bergh A, Widmark A, Johansson A, Lundin E, Adlercreutz H, Hallmans G, Stattin P, Makela S. Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo. Exp Biol Med 2005; 230: 21723.
  • 30
    Chen J, Tan KP, Ward WE, Thompson LU. Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. Exp Biol Med 2003; 228: 9518.
  • 31
    Chen J, Wang L, Thompson LU. Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. Cancer Lett, 2005 May 20 [Epub ahead of print].
  • 32
    Thompson LU, Li T, Chen J, Goss P. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res 2005; 11: 382835.
  • 33
    Brooks J, Ward W, Lewis J, Hilditch J, Nickell L, Wong E, Thompson L. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004; 79: 31825.
  • 34
    Osborne M, Bradlow H, Wong G, Telang N. Upregulation of estradiol C16 α-hydroxylation in human breast tissue: a potential biomarker of breast cancer risk. J Natl Cancer Inst 1993; 85: 191720.
  • 35
    Ju YH, Doerge DR, Allred KF, Allred CD, Helferich WG. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 2002; 62: 24747.
  • 36
    Allred CD, Allred KF, Ju YH, Goeppinger TS, Doerge DR, Helferich WG. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 2004; 25: 164957.
  • 37
    Chen WF, Wong MS. Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells. J Clin Endocrinol Metab 2004; 89: 23519.
  • 38
    Power KA, Thompson LU. Ligand-induced regulation of ERα and ERβ is indicative of human breast cancer cell proliferation. Breast Cancer Res Treat 2003; 81: 20921.
  • 39
    Keinan-Boker L, van Der Schouw YT, Grobbee DE, Peeters PH. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr 2004; 79: 2828.
  • 40
    Brzezinski A, Debi A. Phytoestrogens: the “natural” selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 1999; 85: 4751.
  • 41
    Brzezinski A, Adlercreutz H, Shaoul R, Rosler A, Shmueli A, Tanos V, Schenker J. Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997; 4: 8994.
  • 42
    Lewis RW, Brooks N, Milburn GM, Soames A, Stone S, Hall M, Ashby J. The effects of the phytoestrogen genistein on the postnatal development of the rat. Toxicol Sci 2003; 71: 7483.
  • 43
    Kurzer MS. Phytoestrogen supplement use by women. J Nutr 2003; 133: 1983S86S.