• 1
    Clark LC, Combs GF,Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL,Jr, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial.Nutritional Prevention of Cancer Study Group. JAMA 1996; 276: 195763. [published erratum appears in JAMA 1997; 277: 1520].
  • 2
    Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF,Jr, Park HK, Gross EG, Graham GF, Stratton MS, Marshall JR, Clark LC. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003; 95: 147781.
  • 3
    Duffield-Lillico AJ, Reid ME, Turnbull BW, Combs GF,Jr, Slate EH, Fischbach LA, Marshall JR, Clark LC. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev 2002; 11: 6309.
  • 4
    Reid ME, Duffield-Lillico AJ, Garland L, Turnbull BW, Clark LC, Marshall JR. Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial. Cancer Epidemiol Biomarkers Prev 2002; 11: 128591.
  • 5
    StataCorp. Stata Statistical Software: Release 6.0, ed. 7.0 College Station, TX: Stata Corporation, 2003.
  • 6
    Duffield-Lillico AJ, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, Marshall JR, Clark LC. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int 2003; 91: 60812.
  • 7
    Clark LC, Cantor KP, Allaway WH. Selenium in forage crops and cancer mortality in U.S. counties. Arch Environ Health 1991; 46: 3742.
  • 8
    Schrauzer GN, White DA, Schneider CJ. Cancer mortality correlation studies–III: statistical associations with dietary selenium intakes. Bioinorg Chem 1977; 7: 2331.
  • 9
    Shenberg C, Feldstein H, Cornelis R, Mees L, Versieck J, Vanballenberghe L, Cafmeyer J, Maenhaut W. Br, Rb, Zn, Fe, Se and K in blood of colorectal patients by INAA and PIXE. J Trace Elem Med Biol 1995; 9: 1939.
  • 10
    Ghadirian P, Maisonneuve P, Perret C, Kennedy G, Boyle P, Krewski D, Lacroix A. A case-control study of toenail selenium and cancer of the breast, colon, and prostate. Cancer Detect Prev 2000; 24: 30513.
  • 11
    Nelson RL, Davis FG, Sutter E, Kikendall JW, Sobin LH, Milner JA, Bowen PE. Serum selenium and colonic neoplastic risk. Dis Colon Rectum 1995; 38: 130610.
  • 12
    Beno I, Klvanova J, Magalova T, Brtkova A. Blood levels of natural antioxidants in gastric and colorectal precancerous lesions and cancers in Slovakia. Neoplasma 2000; 47: 3740.
  • 13
    Nomura A, Heilbrun LK, Morris JS, Stemmermann GN. Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J Natl Cancer Inst 1987; 79: 1038.
  • 14
    Caroli S, Coni E, Alimonti A, Petrucci F, Bolis GB, Cristallini E. A pilot study on colon cancer occurrence as related to serum selenium levels. Ann Ist Super Sanita 1994; 30: 2437.
  • 15
    Fernandez-Banares F, Cabre E, Esteve M, Mingorance MD, Abad-Lacruz A, Lachica M, Gil A, Gassull MA. Serum selenium and risk of large size colorectal adenomas in a geographical area with a low selenium status. Am J Gastroenterol 2002; 97: 21038.
    Direct Link:
  • 16
    Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer 1975; 36: 225170.
  • 17
    Stryker SJ, Wolff BG, Culp CE, Libbe SD, Ilstrup DM, MacCarty RL. Natural history of untreated colonic polyps. Gastroenterology 1987; 93: 100913.
  • 18
    Morson BC. Evolution of cancer of the colon and rectum. Cancer 1974; 34: 8459.
  • 19
    Clark LC, Hixson LJ, Combs GF,Jr, Reid ME, Turnbull BW, Sampliner RE. Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1993; 2: 416.
  • 20
    Jacobs ET, Jiang R, Alberts DS, Greenberg ER, Gunter EW, Karagas MR, Lanza E, Ratnasinghe L, Reid ME, Schatzkin A, Smith-Warner SA, Wallace K, et al. Selenium and colorectal adenoma: results of a pooled analysis. J Natl Cancer Inst 2004; 96: 166975.
  • 21
    Bostick RM, Potter JD, McKenzie DR, Sellers TA, Kushi LH, Steinmetz KA, Folsom AR. Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res 1993; 53: 42307.
  • 22
    Knekt P, Aromaa A, Maatela J, Aaran RK, Nikkari T, Hakama M, Hakulinen T, Peto R, Saxen E, Teppo L. Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 1988; 127: 2841.
  • 23
    Early DS, Hill K, Burk R, Palmer I. Selenoprotein levels in patients with colorectal adenomas and cancer. Am J Gastroenterol 2002; 97: 7458.
    Direct Link:
  • 24
    Wallace K, Byers T, Morris JS, Cole BF, Greenberg ER, Baron JA, Gudino A, Spate V, Karagas MR. Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Cancer Epidemiol Biomarkers Prev 2003; 12: 4647.
  • 25
    El-Bayoumy K. The protective role of selenium on genetic damage and on cancer. Mutat Res 2001; 475: 12339.
  • 26
    Redman C, Xu MJ, Peng YM, Scott JA, Payne C, Clark LC, Nelson MA. Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells. Carcinogenesis 1997; 18: 1195202.
  • 27
    McGarrity TJ, Peiffer LP, Hartle RJ. Effect of selenium on growth, S-adenosylmethionine and polyamine biosynthesis in human colon cancer cells. Anticancer Research 1993; 13: 8115.
  • 28
    Feng Y, Finley JW, Davis CD, Becker WK, Fretland AJ, Hein DW. Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2′-dimethyl-4-aminobiphenyl. Toxicol Appl Pharmacol 1999; 157: 3642.
  • 29
    Finley JW, Davis CD. Selenium (Se) from high-selenium broccoli is utilized differently than selenite, selenate and selenomethionine, but is more effective in inhibiting colon carcinogenesis. Biofactors 2001; 14: 1916.
  • 30
    Reddy BS, Rivenson A, Kulkarni N, Upadhyaya P, el-Bayoumy K. Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound 1,4-phenylenebis(methylene)selenocyanate. Cancer Res 1992; 52: 563540.
  • 31
    Mork H, al-Taie OH, Bahr K, Zierer A, Beck C, Scheurlen M, Jakob F, Kohrle J. Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa. Nutr Cancer 2000; 37: 10816.
  • 32
    Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Kearney J, Willett WC. A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. men [see comments]. J Natl Cancer Inst 1994; 86: 18391.
  • 33
    Reid ME, Marshall JR, Roe D, Lebowitz M, Alberts D, Battacharyya AK, Martinez ME. Smoking exposure as a risk factor for prevalent and recurrent colorectal adenomas. Cancer Epidemiol Biomarkers Prev 2003; 12: 100611.
  • 34
    Terry MB, Neugut AI, Bostick RM, Sandler RS, Haile RW, Jacobson JS, Fenoglio-Preiser CM, Potter JD. Risk factors for advanced colorectal adenomas: a pooled analysis. Cancer Epidemiol Biomarkers Prev 2002; 11: 6229.
  • 35
    Giovannucci E. An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2001; 10: 72531.
  • 36
    Giovannucci E. An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer. Am J Med Genet 2001; 101: 24654.
  • 37
    Mark SD, Qiao YL, Dawsey SM, Wu YP, Katki H, Gunter EW, Fraumeni JF,Jr, Blot WJ, Dong ZW, Taylor PR. Prospective study of serum selenium levels and incident esophageal and gastric cancers. J Natl Cancer Inst 2000; 92: 175363.
  • 38
    Rudolph RE, Vaughan TL, Kristal AR, Blount PL, Levine DS, Galipeau PC, Prevo LJ, Sanchez CA, Rabinovitch PS, Reid BJ. Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagus. J Natl Cancer Inst 2003; 95: 7507.