• 1
    Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 527681.
  • 2
    Fillat C, Carrio M, Cascante A, Sangro B. Suicide gene therapy mediated by the Herpes simplex virus thymidine kinase gene/ganciclovir system: fifteen years of application. Curr Gene Ther 2003; 3: 1326.
  • 3
    Seidenfeld J, Gray JW, Marton LJ. Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-α-difluoromethylornithine inhibits proliferation and the G1 to S transition. Exp Cell Res 1981; 131: 20916.
  • 4
    Fredlund JO, Oredsson SM. Normal G1/S transition and prolonged S phase within one cell cycle after seeding cells in the presence of an ornithine decarboxylase inhibitor. Cell Prolif 1996; 29: 45766.
  • 5
    Pasanen T, Karppinen A, Alhonen L, Janne J, Wahlfors J. Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells. Int J Cancer 2003; 104: 3808.
  • 6
    Pasanen T, Hakkarainen T, Timonen P, Parkkinen J, Tenhunen A, Loimas S, Wahlfors J. TK-GFP fusion gene virus vectors as tools for studying the features of HSV-TK/ganciclovir cancer gene therapy in vivo. Int J Mol Med 2003; 12: 52531.
  • 7
    Janne J, Williams-Ashman HG. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme. J Biol Chem 1971; 246: 172532.
  • 8
    Hyvonen T, Keinanen TA, Khomutov AR, Khomutov RM, Eloranta TO. Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography. J Chromatogr 1992; 574: 1721.
  • 9
    Pellinen R, Hakkarainen T, Wahlfors T, Tulimaki K, Ketola A, Tenhunen A, Salonen T, Wahlfors J. Cancer cells as targets for lentivirus-mediated gene transfer and gene therapy. Int J Oncol 2004; 25: 175362.
  • 10
    Kallio A, Seppanen P, Alhonen-Hongisto L, Janne J. Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration. Cancer Res 1983; 43: 3247.
  • 11
    Loimas S, Pasanen T, Gomes A, Bizarro S, Morgan RA, Jänne J, Wahlfors J. Viral vectors carrying a marker-suicide fusion gene (TK-GFP) as tools for TK/GCV-mediated cancer gene therapy. Gene Ther Mol Biol 2000; 5: 16574. Available at