Asthma history, occupational exposure to pesticides and the risk of non-Hodgkin's lymphoma

Authors

  • Won Jin Lee,

    1. Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
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  • Mark P. Purdue,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
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  • Patricia Stewart,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
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  • Maryjean Schenk,

    1. Department of Family Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
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  • Anneclaire J. De Roos,

    1. Program in Epidemiology, Fred Hutchinson Cancer Research Center and the Department of Epidemiology, University of Washington, Seattle, Washington, USA
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  • James R. Cerhan,

    1. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
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  • Richard K. Severson,

    1. Department of Family Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
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  • Wendy Cozen,

    1. Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, CA, USA
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  • Patricia Hartge,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
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  • Aaron Blair

    Corresponding author
    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    • 6120 Executive Blvd. EPS 8118, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
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    • Fax: +1-301-402-1819.


Abstract

We previously reported that, although asthma did not increase the risk of non-Hodgkin's lymphoma (NHL), the risk from pesticide exposures was higher among asthmatics than that among nonasthmatics. To further evaluate this finding, we analyzed data from a population-based case–control study of NHL conducted in Iowa, Detroit, Los Angeles and Seattle. Cases (n = 668) diagnosed with NHL from 1998 to 2000 and controls (n = 543) randomly selected from the same geographical areas as that of the cases were included in this analysis. Odds ratios (OR) for the risk of NHL from potential occupational exposure to pesticides tended to be higher among asthmatics (OR = 1.7; 95% CI 0.3–9.1) when compared with that among nonasthmatics (OR = 0.9; 95% CI 0.6–1.5). The risks of NHL associated with pesticide exposure were also higher among asthmatics who had history of hospitalization (OR = 2.1; 95% CI 0.2–29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics. © 2006 Wiley-Liss, Inc.

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