Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study
Article first published online: 3 OCT 2006
Copyright © 2006 Wiley-Liss, Inc.
International Journal of Cancer
Volume 119, Issue 12, pages 2938–2942, 15 December 2006
How to Cite
Shin, A., Li, H., Shu, X.-O., Yang, G., Gao, Y.-T. and Zheng, W. (2006), Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study. Int. J. Cancer, 119: 2938–2942. doi: 10.1002/ijc.22196
- Issue published online: 26 OCT 2006
- Article first published online: 3 OCT 2006
- Manuscript Accepted: 2 JUN 2006
- Manuscript Received: 20 MAR 2006
- National Institutes of Health. Grant Number: R01 CA70867
- colorectal neoplasms;
- dietary fiber;
We evaluated the associations of dietary intake of calcium, fiber and vitamins with colorectal cancer risk in a population-based prospective cohort study conducted among Chinese women in Shanghai. Subjects were recruited in urban Shanghai from March 1997 to May 2000. All subjects were interviewed in-person to obtain information on demographic and lifestyle factors and anthropometric measurement was conducted. Usual dietary intake, using a validated food frequency questionnaire was assessed at the baseline survey. After following a total of 73,314 women for a median of 5.74 years, 283 incident colorectal cancer cases were recorded. Excluding the first 2 years of follow-up, a high intake of calcium was associated with a decreased risk of colorectal cancer. Comparing the highest quintile of nutrients intake to the lowest, the adjusted relative risk for colorectal cancer was 0.6 (p value for trend = 0.023) for calcium. No apparent associations were found for fiber, total vitamin A, carotene, vitamins B1, B2, B3, C and E with colorectal cancer risk. Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations. © 2006 Wiley-Liss, Inc.