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Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study

  1. Elisa Martró1,2,
  2. Anna Esteve1,
  3. Thomas F. Schulz3,
  4. Julie Sheldon3,
  5. Gemma Gambús1,
  6. Rafael Muñoz1,
  7. Denise Whitby4,†,
  8. Jordi Casabona1,5,‡,*,
  9. Euro-Shaks study group §

Article first published online: 7 DEC 2006

DOI: 10.1002/ijc.22281

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 5, pages 1129–1135, 1 March 2007

Additional Information

How to Cite

Martró, E., Esteve, A., Schulz, T. F., Sheldon, J., Gambús, G., Muñoz, R., Whitby, D., Casabona, J. and Euro-Shaks study group (2007), Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study. Int. J. Cancer, 120: 1129–1135. doi: 10.1002/ijc.22281

Author Information

  1. 1

    Centre d'Estudis Epidemiològics sobre l'HIV/SIDA de Catalunya, Departament de Salut, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

  2. 2

    Microbiology Service, Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Badalona, Spain

  3. 3

    Department of Virology, Hannover Medical School, Hannover, Germany

  4. 4

    Institute for Cancer Research, Chester Beatty Laboratories, London, United Kingdom

  5. 5

    Epidemiology and Public Health Department, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain

  1. †

    Viral Epidemiology Section, AIDS Vaccine Program, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, USA

  1. ‡

    Fax: +34-934-978-889 or +34-934-978-895.

  2. §

    The Euroshaks working group is composed of the members listed above, as well as: Dra. M. Alsina, Dra. E. Buira and Dr. J.M. Gatell (Hospital Clínic, Barcelona, Spain); Dr. M. Vall (SAP Drassanes, Barcelona, Spain); Dra. Anna Rodés (Departament de Salut, Barcelona, Spain); Dr. P. Hermans and Dr. N. Clumeck (St. Pierre Hospital, Brussels, Belgium); Dra. C. Tural, J.C. Martínez, Dr. B. Clotet, (Hospital Universitari Germans Trias i Pujol, Badalona, Spain); Dra. I. Ocaña, Dra. I. Ruiz and Dra. M. Díaz (Hospital de Vall d'Hebron, Barcelona, Spain); Dr. J. Cadafalch, Dra. M. Fusté, Dra. E. Baselga and Dra. M. Alegre (Hospital de Sant Pau, Barcelona, Spain); Dr. F. Bolao, Dra. E. Ferrer and Dr. D. Podzamczer (Hospital de Bellvitge, l'Hospitalet del Llobregat, Spain); Prof. A. Lazzarin, Dr. A. Saracco, Dr. M. Moro and Dr. M.G. Viganó (Hospital San Raffaele, Milan, Italy); Prof. J. Stratigos, Prof. N. Stavrianeas, Dr. D. Polydorou and Dr. C. Botsis (A. Sygros Hospital, Athens, Greece); Dr. D.A. Hawkins and Dr. K. Fife (St. Stephen's Centre, Chelsa & Westminster Hospital, London, UK); Dr. C. Boshoff (Wolfson Institute for Biomedical Research, University College London, UK); Dr. R. Rubio (Hospital 12 de Octubre, Madrid, Spain); Dr. J.L. Colomer (Hospital del Mar, Barcelona, Spain). Laboratory participants: Dr. A. Gaya, Dr. J. Martorell, Dr. J.J. McCarthy, Dr. G. Tambussi, Dr. M. Vounatsou and Dr. M. Hadjivassiliou-Pappa. Interviewers: H. Colpin, M. Vicinanza, and P. Damascos.

*Centre d'Estudis Epidemiològics sobre l'HIV/sida de Catalunya (CEESCAT), Hospital Universitari Germans Trias i Pujol, Ctra de Canyet, s/n. Badalona 08916, Spain

Publication History

  1. Issue published online: 19 JAN 2007
  2. Article first published online: 7 DEC 2006
  3. Manuscript Accepted: 6 JUL 2006
  4. Manuscript Received: 7 DEC 2005

Funded by

  • DG XII of the European Commission (EURO-SHAKS)
  • Fondo de Investigaciones Sanitarias

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References

  • 1
    Kaposi M. Idiopathic multiple pigmented sarcoma of the skin. CA Can J Clin 1982; 32: 342–7.
    Direct Link:
  • 2
    Bayley AC, Cheingsong-Popov R, Dalgleish AG, Downing RG, Tedder RS, Weiss RA. HTLV-III serology distinguishes atypical and endemic Kaposi's sarcoma in Africa. Lancet 1985; 1: 359–61.
  • 3
    IARC Working Group on the evaluation of carcinogenic risks to humans: human immunodeficiency viruses and human T-cell lymphotropic viruses, Lyon, France, 1–18 June 1996. IARC Monogr Eval Carcinog Risks Hum 1996; 67: 1–424.
  • 4
    Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865–9.
  • 5
    Sarid R, Olsen SJ, Moore PS. Kaposi's sarcoma-associated herpesvirus: epidemiology, virology, and molecular biology. Adv Virus Res 1999; 52: 139–232.
  • 6
    Schulz TF. KSHV (HHV8) infection. J Infect 2000; 41: 125–9.
  • 7
    Simpson GR, Schulz TF, Whitby D, Cook PM, Boshoff CH, Rainbow L, Howard MR, Gao S-J, Bohenzky RA, Simmonds P, Lee CA, de Ruiter A, et al. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996; 348: 1133–8.
  • 8
    Gambús G, Bourboulia D, Esteve A, Lahoz R, Rodríguez C, Bolao F, Sirera G, Muga R, del Romero J, Boshoff C, Whitby D, Casabona J. Prevalence and distribution of HHV-8 in different subpopulations, with and without HIV infection, in Spain. AIDS 2001; 15: 1167–74.
  • 9
    O'Brien TR, Kedes D, Ganem D, Macrae DR, Rosenberg PS, Molden J, Goedert JJ. Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis 1999; 180: 1010–17.
  • 10
    Melbye M, Cook PM, Hjalgrim H, Begtrup K, Simpson GR, Biggar RJ, Ebbesen P, Schulz TF. Risk factors for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981–1996. Int J Cancer 1998; 77: 543–8.
    Direct Link:
  • 11
    Renwick N, Halaby T, Weverling GJ, Dukers NHTM, Simpson GR, Coutinho RA, Lange JMA, Schulz TF, Goudsmit J. Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS 1998; 12: 2481–8.
  • 12
    Casabona J, Melbye M, Biggar RJ. Kaposi's sarcoma and non-Hodgkin's lymphoma in European AIDS cases: no excess risk of Kaposi's sarcoma in mediterranean countries. Int J Cancer 1991; 47: 49–53.
    Direct Link:
  • 13
    Rezza G, Dorrucci M, Serraino D, Andreoni M, Giuliani M, Zerboni R, Sarmati L, Colangeli V, Salassa B, Monini P, Ensoli B, Pezzotti P, et al. Incidence of Kaposi's sarcoma and HHV-8 seroprevalence among homosexual men with known dates of HIV seroconversion. Italian Seroconversion Study. AIDS 2000; 14: 1647–53.
  • 14
    Gates AE, Kaplan LD. AIDS malignancies in the era of highly active antiretroviral therapy. Oncology (Huntingt) 2002; 16: 657–65.
  • 15
    Ives NJ, Gazzard BG, Easterbrook PJ. The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART) in a London clinic. J Infect 2001; 42: 134–9.
  • 16
    Mocroft A, Kirk O, Clumeck N, Gargalianos P, Trocha H, Chentsova N, Antunes F, Stellbrink H-J, Phillips AN, Lundgren JD. The changing pattern of Kaposi sarcoma in patients with HIV, 1994–2003: the EuroSIDA study. Cancer 2004; 100: 2644–54.
    Direct Link:
  • 17
    Anderson JE, Wilson RW, Barker P, Doll L, Jones TS, Holtgrave D. Prevalence of sexual and drug-related HIV risk behaviors in the U.S. adult population: results of the 1996 National Household Survey on Drug Abuse. J Acquir Immune Defic Syndr 1999; 21: 148–56.
  • 18
    Sgadari C, Monini P, Barillari G, Ensoli B. Use of HIV protease inhibitors to block Kaposi's sarcoma and tumour growth. Lancet Oncol 2003; 4: 537–47.
  • 19
    EuroHIV2003,HIV/AIDS surveillance in Europe, End-year report 2002, No. 68. European centre for the epidemiological monitoring of AIDS and WHO and UNAIDS collaborating centre on AIDS.
  • 20
    Gnann JW,Jr, Pellett PE, Jaffe HW. Human herpesvirus 8 and Kaposi's sarcoma in persons infected with human immunodeficiency virus. Clin Infect Dis 2000; 30: S72–S76.
  • 21
    Huang LM, Chao MF, Chen MY, Shih H, Chiang YP, Chuang CY, Lee CY. Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1. J Biol Chem 2001; 276: 13427–32.
  • 22
    Jacobson LP, Jenkins FJ, Springer G, Muñoz A, Shah KV, Phair J, Zhang Z-F, Armenian H. Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma. J Infect Dis 2000; 181: 1940–9.
  • 23
    Jacobson LP, Yamashita TE, Detels R, Margolick JB, Chmiel JS, Kingsley LA, Melnick S, Munoz A. Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. J Acquir Immune Defic Syndr 1999; 21 ( Suppl 1): S34–S41.
  • 24
    Campbell TB, Borok M, Gwanzura L, MaWhinney S, White IE, Ndemera B, Gudza I, Fitzpatrick L, Schooley RT. Relationship of human herpesvirus 8 peripheral blood virus load and Kaposi's sarcoma clinical stage. AIDS 2000; 14: 2109–16.
  • 25
    Engels EA, Biggar RJ, Marshall VA, Walters MA, Gamache CJ, Whitby D, Goedert JJ. Detection and quantification of Kaposi's sarcoma-associated herpesvirus to predict AIDS-associated Kaposi's sarcoma. AIDS 2003; 17: 1847–51.
  • 26
    Rezza G, Andreoni M, Dorrucci M, Pezzotti P, Monini P, Zerboni R, Salassa B, Colangeli V, Sarmati L, Nicastri E, Barbanera M, Pristera R, et al. Human herpesvirus 8 seropositivity and risk of Kaposi's sarcoma and other acquired immunodeficiency syndrome-related diseases. J Natl Cancer Inst 1999; 91: 1468–74.
  • 27
    Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998; 338: 948–54.
  • 28
    Kedes DH, Operskalski E, Busch MP, Kohn RP, Flood J, Ganem DE. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996; 2: 918–24.
  • 29
    Gao S-J, Kingsley LA, Li M, Zheng W, Parravicini C, Ziegler JL, Newton R, Rinaldo CR, Saah AJ, Phair JP, Detels R, Chang Y, et al. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 1996; 2: 925–8.
  • 30
    Lennette ET, Blackbourn DJ, Levy JA. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996; 348: 858–61.
  • 31
    Martin JN, Osmond DH. Invited commentary: determining specific sexual practices associated with human herpesvirus 8 transmission. Am J Epidemiol 2000; 151: 225–9.
  • 32
    Monini P, de Lellis L, Fabris M, Rigolin F, Cassai E. Kaposi's sarcoma-associated herpesvirus DNA sequences in prostate tissue and human semen. N Engl J Med 1996; 334: 1168–72.
  • 33
    Howard MR, Whitby D, Bahadur G, Suggett F, Boshoff CH, Tenant-Flowers M, Schulz TF, Kirk S, Matthews S, Weller IVD, Tedder RS, Weiss RA. Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors. AIDS 1997; 11: F15–F19.
  • 34
    Gupta P, Singh MK, Rinaldo C, Ding M, Farzadegan H, Saah A, Hoover D, Moore P, Kingsley L. Detection of Kaposi's sarcoma herpesvirus DNA in semen of homosexual men with Kaposi's sarcoma. AIDS 1996; 10: 1596–8.
  • 35
    Koelle DM, Huang M-L, Chandran B, Vieira J, Piepkorn M, Corey L. Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates. J Infect Dis 1997; 176: 94–102.
  • 36
    Corbellino M, Bestetti G, Galli M, Parravicini C. Absence of HHV-8 in prostate and semen. N Engl J Med 1996; 335: 1237–9.
  • 37
    Vieira J, Huang M-L, Koelle DM, Corey L. Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma. J Virol 1997; 71: 7083–7.
  • 38
    Diamond C, Huang M-L, Kedes DH, Speck C, Rankin GW,Jr, Ganem D, Coombs RW, Rose TM, Krieger JN, Corey L. Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis 1997; 176: 775–7.
  • 39
    Blackbourn DJ, Levy JA. Human herpesvirus 8 in semen and prostate. AIDS 1997; 11: 249, 250.
  • 40
    Pauk J, Huang M-L, Brodie SJ, Wald A, Koelle DM, Schaker T, Celum C, Selke S, Corey L. Mucosal shedding of human herpesvirus 8 in men. N Engl J Med 2000; 343: 1369–77.
  • 41
    Casper C, Redman M, Huang ML, Pauk J, Lampinen TM, Hawes SE, Critchlow CW, Morrow RA, Corey L, Kiviat N, Wald A. HIV infection and human herpesvirus-8 oral shedding among men who have sex with men. J Acquir Immune Defic Syndr 2004; 35: 233–8.
  • 42
    Diamond C, Brodie SJ, Krieger JN, Huang ML, Koelle DM, Diem K, Muthui D, Corey L. Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma. J Virol 1998; 72: 6223–7.
  • 43
    Cannon MJ, Dollard SC, Black JB, Edlin BR, Hannah C, Hogan SE, Patel MM, Jaffe HW, Offermann MK, Spira TJ, Pellett PE, Gunthel CJ. Risk factors for Kaposi's sarcoma in men seropositive for both human herpesvirus 8 and human immunodeficiency virus. AIDS 2003; 17: 215–22.
  • 44
    Casabona J, Gambús G, Vall M, Rodés A. Risk factors for AIDS associated Kaposi's sarcoma. Pathol Oncol Res 1997; 3: 74–7.
  • 45
    Centers for Disease Control and Prevention (United States). 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992; 41: 1–19.
  • 46
    Hosmer DW,Jr, Lemeshow S. Applied logistic regression. New York: Wiley, 1989.
  • 47
    Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection. N Engl J Med 1995; 332: 1181–5.
  • 48
    Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, Biggar RJ: Interlaboratory Collaborative Group (United States). Interassay correlation of human herpesvirus 8 serologic tests. J Infect Dis 1998; 178: 304–9.
  • 49
    Beral V, Bull D, Darby SC, Weller IVD, Carne CA, Beecham M, Jaffe HW. Risk of Kaposi's sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS. Lancet 1992; 339: 632–5.
  • 50
    Kaldor JM, Tindall B, Williamson P, Elford J, Cooper DA. Factors associated with Kaposi's sarcoma in a cohort of homosexual and bisexual men. J Acquir Immune Defic Syndr 1993; 6: 1145–9.
  • 51
    Armenian HK, Hoover DR, Rubb S, Metz S, Kaslow R, Visscher B, Chmiel J, Kingsley L, Saah A. Composite risk score for Kaposi's sarcoma based on a case-control and longitudinal study in the Multicenter AIDS Cohort Study (MACS) population. Am J Epidemiol 1993; 138: 256–65.
  • 52
    Hoover DR, Black CA, Jacobson LP, Martínez Maza O, Seminara D, Saah AJ, Von Roenn J, Anderson R, Armenian HK. Epidemiologic analysis of Kaposi's sarcoma as an early and later AIDS outcome in homosexual men. Am J Epidemiol 1993; 138: 266–78.
  • 53
    Gaya A, Esteve A, Casabona J, McCarthy JJ, Martorell J, Schulz TF, Whitby D. Amino acid residue at position 13 in HLA-DR β chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. AIDS 2004; 18: 199–204.
  • 54
    Smith NA, Sabin CA, Gopal R, Bourboulia D, Labbet W, Boshoff C, Barlow D, Band B, Peters BS, de Ruiter A, Brown DWG, Weiss RA, et al. Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex. J Infect Dis 1999; 180: 600–6.
  • 55
    Grulich AE, Kaldor JM, Hendry O, Luo K, Bodsworth NJ, Cooper DA. Risk of Kaposi's sarcoma and oroanal sexual contact. Am J Epidemiol 1997; 145: 673–9.
  • 56
    Diamond C, Thiede H, Perdue T, MacKellar D, Valleroy LA, Corey L. Seroepidemiology of human herpesvirus 8 among young men who have sex with men. Sex Transm Dis 2001; 28: 176–83.
  • 57
    Grulich AE, Olsen SJ, Luo K, Hendry O, Cunningham P, Cooper DA, Gao S-J, Chang Y, Moore PS, Kaldor JM. Kaposi's sarcoma-associated herpesvirus: a sexually transmissible infection? J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20: 387–93.
  • 58
    Armenian HK Hoover DR Rubb S Metz S Kaslow RA Visscher BR Chmiel JS Kingsley LA Saah AJ Composite risk score for Kaposi's sarcoma based on a case-control and longitudinal study in Multicenter AIDS Cohort Study (MACS) population Am J Epidemiol 1993; 138: 256–65.
  • 59
    Dukers NH, Renwick N, Prins M, Geskus RB, Schulz TF, Weverling G-J, Coutinho RA, Goudsmit J. Risk factors for human herpesvirus 8 seropositivity and seroconversion in a cohort of homosexual men. Am J Epidemiol 2000; 151: 213–24.
  • 60
    Goudsmit J, Renwick N, Dukers NH, Coutinho RA, Heisterkamp S, Bakker M, Schulz TF, Cornelissen M, Weverling GJ. Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984–1997): analysis of seroconversions to ORF65 and ORF73. Proc Natl Acad Sci USA 2000; 97: 4838–43.
  • 61
    Boldogh I, Szaniszlo P, Bresnahan WA, Flaitz CM, Nichols MC, Albrecht T. Kaposi's sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus. Clin Infect Dis 1996; 23: 406, 407.
  • 62
    Blackbourn DJ, Lennette ET, Ambroziak J, Mourich DV, Levy JA. Human herpesvirus 8 detection in nasal secretions and saliva. J Infect Dis 1998; 177: 213–16.
  • 63
    Dedicoat M, Newton R, Alkharsah KR, Sheldon J, Szabados I, Ndlovu B, Page T, Casabonne D, Gilks CF, Cassol SA, Whitby D, Schulz TF. Mother-to-child transmission of human herpesvirus-8 in South Africa. J Infect Dis 2004; 190: 1068–75.
  • 64
    Mayama S, Cuevas LE, Sheldon J, Omar OH, Smith DH, Okong P, Silvel B, Hart CA, Schulz TF. Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 1998; 77: 817–20.
    Direct Link:
  • 65
    Lefrère JJ, Meyohas MC, Mariotti M, Meynard JL, Thauvin M, Frottier J. Detection of human herpesvirus 8 DNA sequences before the appearance of Kaposi's sarcoma in human immunodeficiency virus (HIV) - positive subjects with a known date of HIV seroconversion. J Infect Dis 1996; 174: 283–7.
  • 66
    Verbeek W, Frankel M, Miles SA, Said JW, Koeffler HP. Seroprevalence of HHV8 antibodies in HIV-positive homosexual men without Kaposi's sarcoma and their clinical follow-up. Am J Clin Pathol 1998; 109: 778–83.
  • 67
    Gill J, Bourboulia D, Wilkinson J, Hayes P, Cope A, Marcelin AG, Calvez V, Gotch F, Boshoff C, Gazzard B. Prospective study of the effects of antiretroviral therapy on Kaposi sarcoma-associated herpesvirus infection in patients with and without Kaposi sarcoma. J Acquir Immune Defic Syndr 2002; 31: 384–90.
  • 68
    Bourboulia D, Aldam D, Lagos D, Allen E, Williams I, Cornforth D, Copas A, Boshoff C. Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia. AIDS 2004; 18: 485–93.
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