1097-0215/asset/cover.gif?v=1&s=9bea5e55449dab2cff7ad3b06277cc9745417a23 "International Journal of Cancer")
Fax: +801-585-3408; +801-587-9415.
1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
Cancer Cell Biology
You have full text access to this OnlineOpen article
Disease-associated casein kinase I δ mutation may promote adenomatous polyps formation via a Wnt/β-catenin independent mechanism
Article first published online: 27 NOV 2006
DOI: 10.1002/ijc.22368
Copyright © 2006 Wiley-Liss, Inc.
Additional Information
How to Cite
Tsai, I.-C., Woolf, M., Neklason, D. W., Branford, W. W., Yost, H. J., Burt, R. W. and Virshup, D. M. (2007), Disease-associated casein kinase I δ mutation may promote adenomatous polyps formation via a Wnt/β-catenin independent mechanism. Int. J. Cancer, 120: 1005–1012. doi: 10.1002/ijc.22368
Publication History
- Issue published online: 19 JAN 2007
- Article first published online: 27 NOV 2006
- Manuscript Accepted: 5 SEP 2006
- Manuscript Received: 10 MAY 2006
Funded by
- Huntsman Cancer Foundation
- Willard Snow Hansen Chair for Cancer Research
- Utah Cancer Registry
- NIH. Grant Numbers: R01 CA40641, P01 CA73992, R01 CA80809
- Cancer Center Support. Grant Number: P30 CA42014
- Utah Department of Health
- University of Utah
References
- 1, . Wnt signaling: a common theme in animal development. Genes Dev 1997; 11: 3286–305.
- 2, . Wnt signalling in stem cells and cancer. Nature 2005; 434: 843–50.
- 3, , , . Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998; 94: 109–18.
- 4, , . Wnt/frizzled activation of Rho regulates vertebrate gastrulation and requires a novel formin homology protein Daam1. Cell 2001; 107: 843–54.
- 5, , , , , , , . JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep 2002; 3: 69–75.
- 6, , . A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003; 5: 367–77.
- 7, , , , . The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 2000; 16: 279–83.
- 8, , , . The Wnt/calcium pathway activates NF–AT and promotes ventral cell fate in Xenopus embryos. Nature 2002; 417: 295–9.
- 9, , , , , , , . Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 2002; 16: 1066–76.
- 10, , , , , , , , . Control of β-catenin phosphorylation/degradation by a dual- kinase mechanism. Cell 2002; 108: 837–47.
- 11, , , , , , , . Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005; 438: 867–72.
- 12, , , , , , , , . A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005; 438: 873–7.
- 13, , , . Casein kinase I transduces Wnt signals. Nature 1999; 401: 345–50.
- 14, , , , . Casein kinase I ε in the wnt pathway: regulation of β-catenin function. Proc Natl Acad Sci USA 1999; 96: 12548–52.
- 15, , , . Casein kinase I ε enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin. J Biol Chem 2003; 278: 14066–73.
- 16, , , , , , . Negative regulation of LRP6 function by casein kinase I ε phosphorylation. J Biol Chem 2006; 281: 12233–41.
- 17, , , , . Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex. Proc Natl Acad Sci USA 2002; 99: 1182–7.
- 18, , , , , , , . Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase I ε. J Biol Chem 2001; 276: 33147–55.
- 19, , . Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1 ε. J Biol Chem 2001; 276: 39037–45.
- 20, , , , , , , , , , , . T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. Cancer Res 2002; 62: 3009–13.
- 21, , , . Crystal structure of a β-catenin/axin complex suggests a mechanism for the β-catenin destruction complex. Genes Dev 2003; 17: 2753–64.
- 22, , . Casein kinase Iε modulates the signaling specificities of dishevelled. Mol Cell Biol 2004; 24: 2000–11.
- 23, , . The casein kinase I family: roles in morphogenesis. Dev Biol 2001; 235: 378–87.
- 24
- 25, , , . Regulation of casein kinase I ε and casein kinase I δ by an in vivo futile phosphorylation cycle. J Biol Chem 1998; 273: 15980–4.
- 26, , , , , , . Regulation of casein kinase I ε activity by Wnt signaling. J Biol Chem 2004; 279: 13011–17.
- 27, , , , , , . Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 1997; 275: 1787–90.
- 28, , , , . The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 1996; 134: 165–79.
- 29, , , , , . Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin. Oncogene 1997; 15: 2833–9.
- 30, , . Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene 1992; 7: 487–92.
- 31, , , , , , , . Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 2000; 28: 443–53.Direct Link:
- 32, , , . Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database. Fam Cancer 2005; 4: 239–44.
- 33, . Biomedical databases: protecting privacy and promoting research. Trends Biotechnol 2003; 21: 113–16.
- 34, , , , , , , , , , . A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58: 5248–57.
- 35, , , , , , , , , . HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. Cancer Res 2000; 60: 2225–31.
- 36, , , , , , , . Evaluation of microsatellite instability and immunohistochemistry for the prediction of germ-line MSH2 and MLH1 mutations in hereditary nonpolyposis colon cancer families. Cancer Res 2002; 62: 3485–92.
- 37, , . Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev 1994; 8: 1311–23.
- 38, . Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev 1994; 8: 1434–47.
- 39. Colon cancer screening. Gastroenterology 2000; 119: 837–53.
- 40, , , , , , , . Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 1997; 275: 1784–7.
- 41, , , . Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 ε, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res 2004; 64: 942–51.
- 42. WNT/PCP signaling pathway and human cancer (review). Oncol Rep 2005; 14: 1583–8.
- 43, , , , , , , . Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci USA 2006; 103: 5454–9.
- 44, , , , , , , . Wnts induce migration and invasion of myeloma plasma cells. Blood 2005; 106: 1786–93.
- 45, , , , , , , . Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem 2005; 280: 777–86.
- 46, . Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity. Curr Opin Cell Biol 2005; 17: 482–8.
- 47, , , , , . A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol 2004; 24: 4184–95.
- 48, , , , . An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc Natl Acad Sci USA 2006; 103: 10618–23.
- 49, , , , , , . Double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Development 1999; 126: 5409–20.