Tumor Immunology

You have full text access to this OnlineOpen article

Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung

  1. Masakazu Sugaya†,*,
  2. Mitsuhiro Takenoyama,
  3. Yoshiki Shigematsu,
  4. Tetsuro Baba,
  5. Takashi Fukuyama,
  6. Yoshika Nagata,
  7. Makiko Mizukami,
  8. Tetsuya So,
  9. Yoshinobu Ichiki,
  10. Manabu Yasuda,
  11. Tomoko So,
  12. Takeshi Hanagiri,
  13. Kenji Sugio,
  14. Kosei Yasumoto

Article first published online: 27 NOV 2006

DOI: 10.1002/ijc.22396

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 5, pages 1055–1062, 1 March 2007

Additional Information

How to Cite

Sugaya, M., Takenoyama, M., Shigematsu, Y., Baba, T., Fukuyama, T., Nagata, Y., Mizukami, M., So, T., Ichiki, Y., Yasuda, M., So, T., Hanagiri, T., Sugio, K. and Yasumoto, K. (2007), Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. Int. J. Cancer, 120: 1055–1062. doi: 10.1002/ijc.22396

Author Information

  1. The Second Department of Surgery, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan

  1. †

    Fax: +81-93-692-4004.

*The Second Department of Surgery, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

Publication History

  1. Issue published online: 19 JAN 2007
  2. Article first published online: 27 NOV 2006
  3. Manuscript Accepted: 4 SEP 2006
  4. Manuscript Received: 15 FEB 2006

Funded by

  • Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (261K)

References

  • 1
    van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991; 254: 1643–47.
  • 2
    Boel P, Wildmann C, Sensi ML, Brasseur R, Renauld JC, Coulie PG, Boon T, van der Bruggen P. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity 1995; 2: 167–75.
  • 3
    Coulie PG, Brichard V, Van Pel A, Wolfel T, Schneider J, Traversari C, Mattei S, De Plaen E, Lurquin C, Szikora JP. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med 1994; 180: 35–42.
  • 4
    Marchand M, Weynants P, Rankin E, Arienti F, Belli F, Parmiani G, Cascinelli N, Bourlond A, Vanwijck R, Humblet Y. Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3. Int J Cancer 1995; 63: 883–5.
    Direct Link:
  • 5
    Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, Restifo NP, Dudley ME, Schwarz SL, Spiess PJ, Wunderlich JR, Parkhurst MR, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med 1998; 4: 321–7.
  • 6
    Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K. A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J Exp Med 1998; 187: 277–88.
  • 7
    Suzuki K, Sahara H, Okada Y, Yasoshima T, Hirohashi Y, Nabeta Y, Hirai I, Torigoe T, Takahashi S, Matsuura A, Takahashi N, Sasaki A, et al. Identification of natural antigenic peptide of a human gastric signet ring cell carcinoma recognized by HLA-A31-restricted cytotoxic T lymphocytes. J Immunol 1999; 163: 2783–91.
  • 8
    So T, Takenoyama M, Mizukami M, Ichiki Y, Sugaya M, Hanagiri T, Sugio K, Yasumoto K. Haplotype loss of HLA class I antigen as an escape mechanism from immune attack in lung cancer. Cancer Res 2005; 65: 5945–52.
  • 9
    Nagata Y, Hanagiri T, Takenoyama M, Fukuyama T, Mizukami M, So T, Ichiki Y, Sugaya M, Sugio K, Yasumoto K, Boon T, Coulie PG. Identification of the HLA-Cw*0702-restricted tumor-associated antigen recognized by a CTL clone from a patient with lung cancer. Clin Cancer Res 2005; 1: 5265–72.
  • 10
    Takenoyama M, Baurain JF, Yasuda M, So T, Sugaya M, Hanagiri T, Sugio K, Yasumoto K. A point mutation in the NF-YC gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human squamous cell lung carcinoma. Int J Cancer 2006; 118: 1992–7.
    Direct Link:
  • 11
    Takenoyama M, Yoshino I, Fujie H, Hanagiri T, Yoshimatsu T, Imahayashi S, Eifuku R, Nomoto K, Yasumoto K. Autologous tumor-specific cytotoxic T lymphocytes in a patient with lung adenocarcinoma: implications of the shared antigens expressed in HLA-A24 lung cancer cells. Jpn J Cancer Res 1998; 89: 60–6.
  • 12
    So T, Takenoyama M, Sugaya M, Yasuda M, Eifuku R, Yoshimatsu T, Hanagiri T, Oyama T, Kodate M, Osaki T, Yasumoto K. Generation of autologous tumor-specific T cell clones from a patient with adenosquamous carcinoma of the lung. Jpn J Clin Oncol 2001; 31: 311–17.
  • 13
    Sugaya M, Takenoyama M, Osaki T, Yasuda M, Nagashima A, Sugio K, Yasumoto K. Establishment of 15 cancer cell lines from patients with lung cancer and potential tools for immunotherapy. Chest 2002; 122: 282–8.
  • 14
    Ichiki Y, Hanagiri T, Takenoyama M, Baba T, Fukuyama T, Nagata Y, Mizukami M, So T, Sugaya M, Yasuda M, So T, Sugio K, Yasumoto K. Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer. J Immunol 2004; 172: 4844–50.
  • 15
    Baurain JF, Colau D, van Baren N, Landry C, Martelange V, Vikkula M, Boon T, Coulie PG. High frequency of autologous antimelanoma CTLs directed against an antigen generated by a point mutation in a new helicase gene. J Immunol 2000; 164: 6057–66.
  • 16
    Pittet MJ, Speiser DE, Lienard D, Valmori D, Guillaume P, Dutoit V, Rimoldi D, Lejeune F, Cerottini JC, Romero P. Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide. Clin Cancer Res 2001; 7: 796–803.
  • 17
    Karanikas V, Colau D, Baurain JF, Chiari R, Thonnard J, Gutierrez-Roelens I, Goffinet C, Van Schaftingen EV, Weynants P, Boon T, Coulie PG. High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival. Cancer Res 2001; 61: 3718–24.
  • 18
    Mountain CF, Dresler CM. Regional lymph node classification for lung cancer staging. Chest 1997; 111: 1718–23.
  • 19
    Takenoyama M, Yoshino I, Eifuku R, So T, Imahayashi S, Sugaya M, Yasuda M, Inoue M, Ichiyoshi Y, Osaki T, Nagashima A, Nomoto K et al. Successful induction of tumor-specific cytotoxic T lymphocytes from patients with non-small cell lung cancer using CD80-transfected autologous tumor cells. Jpn J Cancer Res 2001; 92: 309–15.
  • 20
    Takenoyama M, Yasumoto K, Harada M, Matsuzaki G, Ishida T, Sugimachi K, Nomoto K. Expression of activation-related molecules on regional lymph node lymphocytes in human lung cancer. Immunobiology 1996; 195: 140–51.
  • 21
    Lehmann F, Marchand M, Hainaut P, Pouillart P, Sastre X, Ikeda H, Boon T, Coulie PG. Differences in the antigens recognized by cytolytic T cells on two successive metastasis of a melanoma patient are consistent with immune selection. Eur J Immunol 1995; 25: 340–7.
    Direct Link:
  • 22
    Espevik T, Nissen-Meyer J. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods 1986; 95: 99–105.
  • 23
    Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 1989; 119: 203–10.
  • 24
    Heidecker L, Brasseur F, Probst-Kepper M, Gueguen M, Boon T, van der Eynde. Cytolytic T lymphocytes raised against a human bladder carcinoma recognized an antigen encoded by gene MAGE-A12. J Immunol 2000; 164: 6041–5
  • 25
    Geneve'e C, Diu A, Nierat J, Caignard A, Dietrich PY, Ferradini L, Roman-Roman S, Triebel F, Hercend T. An experimentally validated panel of subfamily-specific oligonucleotide primers (Vα 1-w29/V β 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur J Immunol 1992; 22: 1261–9.
    Direct Link:
  • 26
    Manfras BJ, Rudert WA, Trucco M, Boehm BO. Analysis of the αβ T-cell receptor repertoire by competitive and quantitative family-specific PCR with exogenous standards and high resolution fluorescence based CDR3 size imaging. J Immunol Methods 1997; 210: 235–49.
  • 27
    Chiari R, Foury E, Plaen ED, Baurain JF, Thonnard J, Coulie PG. Two antigens recognized by autololgous cytotoxic T lymphocytes on a melanoma result from point mutation in an essential housekeeping gene. Cancer Res 1999; 59: 5785–92.
  • 28
    Echchakir H, Mami-Chouaib F, Vergnon I, Baurain JF, Karanikas V, Chouaib S, Coulie PG. A point mutation in the α-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma. Cancer Res 2001; 61: 4078–83.
  • 29
    Echchakir H, Vergnon I, Dorothee G, Grunenwald D, Chouaib S, Mami-Chouaib F. Evidence for in situ expansion of diverse antitumor-specific cytotoxic T lymphocyte clones in a human large cell carcinoma of the lung. Int Immunol 2000; 12: 537–46.
  • 30
    Slingluff CL,Jr, Cox AL, Stover JM,Jr, Moore MM, Hunt DF, Engelhard VH. Cytotoxic T-lymphocyte response to autologous human squamous cell cancer of the lung: epitope reconstitution with peptides extracted from HLA-Aw68. Cancer Res 1994; 54: 2731–7.
  • 31
    Hishii M, Andrews D, Boyle LA, Wong JT, Pandolfi F, van den Elsen PJ, Kurnick JT. In vivo accumulation of the same anti-melanoma T cell clone in two different metastatic sites. Proc Natl Acad Sci USA 1997; 94: 1378–84.
  • 32
    Osaki T, Oyama T, Inoue M, Gu CD, Kodate M, Aikawa M, So T, Mizukami M, Mitsudomi T, Yasumoto K. Molecular biological markers and micrometastasis in resected non-small-cell lung cancer. Prognostic implications. Jpn J Thorac Cardiovasc Surg 2001; 49: 545–51.
  • 33
    Yasumoto K, Osaki T, Watanabe Y, Kato H, Yoshimura T. Prognostic value of cytokeratin-positive cells in the bone marrow and lymph nodes of patients with resected nonsmall cell lung cancer: a multicenter prospective study. Ann Thorac Surg 2003; 76: 194–201.
  • 34
    Coulie PG, Karanikas V, Colau D, Lurquin C, Landry C, Marchand M, Dorval T, Brichard V, Boon T. A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3. Proc Natl Acad Sci USA 2001; 28: 10290–5.
  • 35
    Lupas A. Coiled coils; new structures and new functions. Trends Biochem Sci 1996; 21: 375–82.
  • 36
    Seipel K, O'Brien SP, Iannotti E, Medley QG, Streuli M. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. J Cell Sci 2000; 114: 389–99.
  • 37
    Robbins PF, el-Gamil M, Li YF, Topalian SL, Rivoltini L, Sakaguchi K, Appella E, Kawakami Y, Rosenberg SA. Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24- restricted tumor-infiltrating lymphocytes. J Immunol 1995; 154: 5944–50.
  • 38
    Engelhard VH. Creating new peptide antigens by slicing and splicing proteins. Nat Immunol 2004; 5: 128–9.
  • 39
    Hanada K, Yewdell JW, Yang JC. Immune recognition of a human renal cancer antigen through post-translational protein splicing. Nature 2004; 427: 252–6.
  • 40
    Schultz ES, Chapiro J, Lurquin C, Claverol S, Burlet-Schiltz O, Warnier G, Russo V, Morel S, Levy F, Boon T, Van den Eynde BJ, van der Bruggen P. The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome. J Exp Med 2002; 195: 391–9.
  • 41
    Date Y, Kimura A, Sasazuki T. DNA typing of the HLA-A gene: population study and identification of four new alleles in Japanese. Tissue Antigens 1996; 47: 93–101.
    Direct Link:
View Full Article (HTML) Get PDF (261K)