Epidemiology

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Risk of second malignant neoplasms among lymphoma patients with a family history of cancer

  1. Ola Landgren1,†,*,
  2. Ruth M. Pfeiffer1,
  3. Laveta Stewart1,
  4. Gloria Gridley1,
  5. Lene Mellemkjaer2,
  6. Kari Hemminki3,4,
  7. Lynn R. Goldin1,
  8. Lois B. Travis1

Article first published online: 27 NOV 2006

DOI: 10.1002/ijc.22414

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 5, pages 1099–1102, 1 March 2007

Additional Information

How to Cite

Landgren, O., Pfeiffer, R. M., Stewart, L., Gridley, G., Mellemkjaer, L., Hemminki, K., Goldin, L. R. and Travis, L. B. (2007), Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. Int. J. Cancer, 120: 1099–1102. doi: 10.1002/ijc.22414

Author Information

  1. 1

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD

  2. 2

    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark

  3. 3

    Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden

  4. 4

    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany

  1. †

    Fax: +301-402-4489.

*Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Bldg. EPS/Room 7110, Bethesda, MD 20892-7236, USA

Publication History

  1. Issue published online: 19 JAN 2007
  2. Article first published online: 27 NOV 2006
  3. Manuscript Accepted: 15 SEP 2006
  4. Manuscript Received: 15 MAY 2006

Funded by

  • NIH, National Cancer Institute, DCEG

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Keywords:

  • Hodgkin lymphoma;
  • non-Hodgkin lymphoma;
  • chronic lymphocytic leukemia;
  • susceptibility;
  • DNA repair mechanisms;
  • second neoplasm;
  • family history;
  • familial aggregation

Abstract

Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL) (n = 25,941), or chronic lymphocytic leukemia (CLL) (n = 7,764), using a large population-based database. Family history of cancer was based on a diagnosis of any cancer in 110,862 first-degree relatives. We found increased relative risk (RR) (1.81, 95% confidence interval (CI): 1.04–3.16) of breast cancer among HL patient with positive (vs. negative) family history of cancer. Among CLL patients with positive (vs. negative) family history of cancer, we observed elevated risks of bladder (RR = 3.53, 95% CI: 1.31–9.55) and prostate cancer (RR = 2.15, 95% CI: 1.17–3.94). For NHL patients with positive (vs. negative) family history of cancer, we observed non-significantly increased risk of non-melanoma skin cancer (RR = 1.94, 95% CI: 0.86–4.38) and lung cancer (RR = 1.99, 95% CI: 0.73–5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders. © 2006 Wiley-Liss, Inc.

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