Early Detection and Diagnosis

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Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance†

  1. Carsten Kempkensteffen1,‡,*,
  2. Stefan Hinz1,
  3. Frank Christoph1,
  4. Jens Köllermann2,
  5. Hans Krause1,
  6. Mark Schrader1,
  7. Martin Schostak1,
  8. Kurt Miller1,
  9. Steffen Weikert1

Article first published online: 7 DEC 2006

DOI: 10.1002/ijc.22416

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 5, pages 1081–1086, 1 March 2007

Additional Information

How to Cite

Kempkensteffen, C., Hinz, S., Christoph, F., Köllermann, J., Krause, H., Schrader, M., Schostak, M., Miller, K. and Weikert, S. (2007), Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Int. J. Cancer, 120: 1081–1086. doi: 10.1002/ijc.22416

Author Information

  1. 1

    Department of Urology, Charité – Campus Benjamin Franklin, Universitätsmedizin Berlin, Berlin, Germany

  2. 2

    Department of Pathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

  1. ‡

    Fax: +49-30-84-45-44-48.

*Department of Urology, Charité – Campus Benjamin Franklin, Universitätsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany

  1. †

    Role of the funding source: The sponsor of this study had no role in the study design; in the collection, analysis, or interpretation of the data; or in the writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

Publication History

  1. Issue published online: 19 JAN 2007
  2. Article first published online: 7 DEC 2006
  3. Manuscript Accepted: 21 SEP 2006
  4. Manuscript Received: 29 JUL 2006

Funded by

  • Charité – Campus Benjamin Franklin
  • Universitätsmedizin Berlin

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Keywords:

  • inhibitor of apoptosis;
  • cIAP1;
  • cIAP2;
  • renal cell carcinoma;
  • prognosis

Abstract

The expression of the inhibitor of apoptosis (IAP) family members cIAP1 and cIAP2 have been shown to be altered in various cancer entities. This study was done to characterize the tumor-related expression profile of cIAP1 and cIAP2 in patients with renal cell carcinomas (RCC) and to evaluate its potential predictive value after curative resection. Expression of cIAP1 and cIAP2 was analyzed by real-time RT-PCR in RCC and corresponding normal tissue samples obtained from a cohort of 127 RCC patients (median follow-up: 48 months) undergoing surgical treatment. Expression data was correlated to histopathological variables and outcome. Overexpression of cIAP1 and cIAP2 occurred in most RCC specimens (p < 0.001), but 20% of the patients had lower cIAP levels in malignant than in normal tissue. The cIAP1 expression correlated with the tumor stage, levels being higher in pT1 tumors than in advanced pathological stages (p = 0.002). Decreased cIAP1 expression in RCC relative to paired normal samples predicted an abbreviated time to recurrence (hazard rate 2.96; 95% CI: 1.23–7.09) and tumor-specific survival (hazard rate 2.78; 95% CI: 1.22–6.38) irrespective of the tumor stage and grade. The prognostic effect of cIAP1 was most pronounced in patients with pT3 disease (log rank test p = 0.001). The results of uni- and multivariate analysis suggest a prognostic value of cIAP1 expression for RCC patients, downregulation indicating an aggressive, potentially lethal phenotype. © 2006 Wiley-Liss, Inc.

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