Fax: 713-7900545.
Carcinogenesis
You have full text access to this OnlineOpen article
Loss of chromosomal integrity drives rat mammary tumorigenesis
Article first published online: 27 NOV 2006
DOI: 10.1002/ijc.22420
Copyright © 2006 Wiley-Liss, Inc.
Additional Information
How to Cite
Goepfert, T. M., Moreno-Smith, M., Edwards, D. G., Pathak, S., Medina, D. and Brinkley, W.R. (2007), Loss of chromosomal integrity drives rat mammary tumorigenesis. Int. J. Cancer, 120: 985–994. doi: 10.1002/ijc.22420
Publication History
- Issue published online: 19 JAN 2007
- Article first published online: 27 NOV 2006
- Manuscript Accepted: 25 SEP 2006
- Manuscript Received: 3 AUG 2006
Funded by
- NIH. Grant Numbers: CA 64255, CA 41424
References
- 1, . Experimentally induced mammary tumors in rats. Breast Cancer Res Treat 1996; 39: 7–20.
- 2, , , , . Pathology of tumours in laboratory animals. Tumours of the rat. Tumours of the mammary gland. IARC Sci Publ 1990; 99: 47–78.
- 3, , , , , , , . Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats. Carcinogenesis 1998; 19: 1573–81.
- 4. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res 1985; 45: 3415–43.
- 5
- 6, , . Classification of premalignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea. J Mammary Gland Biol Neoplasia 2000; 5: 201–10.
- 7, . Histopathogenesis of 7,12-diemthylbenz(a) anthracene-induced rat mammary tumors. Proc Natl Acad Sci USA 1977; 74: 4020–4.
- 8, , , , , . Comparative study of human and rat mammary tumorigenesis. Lab Invest 1990; 62: 244–78.
- 9, , . Chromosome alterations in rat mammary tumor progression. Prog Clin Biol Res 1992; 376: 137–53.
- 10, , , , , , , . A comparative analysis of allelic imbalance events in chemically induced rat mammary, colon, and bladder tumors. Mol Carcinog 1999; 24: 47–56.Direct Link:
- 11, , , , . Nonrandom abnormalities involving chromosome 1 and Harvey-ras-1 alleles in rat mammary tumor progression. Cancer Res 1992; 52: 4791–8.
- 12, , , . Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature 1983; 306: 658–61.
- 13, , , . Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats. Carcinogenesis 1996; 17: 2519–24.
- 14, , , , . The stroma as a crucial target in rat mammary gland carcinogenesis. J Cell Sci 2004; 117 (Part 8): 1495–502.
- 15, , , , , . Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors. Mol Carcinog 1997; 20: 194–203.Direct Link:
- 16, , , , , . Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res 2002; 62: 4115–22.
- 17. Genetic control of resistance to chemically induced mammary adenocarcinogenesis in the rat. Cancer Res 1986; 46: 3958–63.
- 18, , , . Influence of age and gland topography on cell kinetics of normal human breast tissue. J Natl Cancer Inst 1987; 78: 413–8.
- 19, . Methods in mammary gland biology and breast cancer research. Boston: Kluwer, 2000.
- 20, , , . Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res 1959; 19: 515–20.
- 21. Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch B Cell Pathol Incl Mol Pathol 1977; 24: 227–42.
- 22, , , . Cytogenetic characterization and DNA content analysis of Ad 2-transformed rat embryo brain cells. Anticancer Res 1984; 4: 367–74.
- 23. Chromosome banding techniques. J Reprod Med 1976; 17: 25–8.
- 24, , , . A high-resolution G-banding idiogram of Rattus norvegicus chromosomes. Cytobios 1990; 62: 153–60.
- 25, , , , . Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res 1999; 59: 4276–84.
- 26, , , , , . An in vitro model of epithelial cell growth stimulation in the rodent mammary gland. Cell Prolif 2003; 36: 177–90.Direct Link:
- 27, , , , , . Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. Arthritis Rheum 1998; 41: 551–8.Direct Link:
- 28
- 29, , , , , , . Id-1 is not expressed in the luminal epithelial cells of mammary glands. Breast Cancer Res 2003; 5: R25–R9.
- 30, , , , . Dual role for the latent transforming growth factor-β binding protein in storage of latent TGF-β in the extracellular matrix and as a structural matrix protein. J Cell Biol 1995; 131: 539–49.
- 31, , , , . Allelotypic and cytogenetic characterization of chemically induced mouse mammary tumors: high frequency of chromosome 4 loss of heterozygosity at advanced stages of progression. Mol Carcinog 1996; 17(3): 126–33.Direct Link:
- 32See reference 10.
- 33, , , , , , , , . Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer. Mol Carcinog 2002; 33: 56–65.Direct Link:
- 34, , , . Telomere dynamics, aneuploidy, stem cells, and cancer (review). Int J Oncol 2002; 20: 637–41.
- 35, . Cellular kinetics of rat mammary gland terminal end bud epithelium exposed to N-methyl-N-nitrosourea in vivo. Cancer Res 1992; 52: 5076–81.
- 36. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer 2002; 2: 815–25.
- 37, . Controlling centrosome number: licenses and blocks. Curr Opin Cell Biol 2006; 18(1): 74–8.
- 38, , , . Structure meets function-centrosomes, genome maintenance and the DNA damage response. Exp Cell Res 2006; 312: 2633–40.
- 39, , , , , , , , , , , , et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434: 864–70.
- 40, , , , , , , , , , , , et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434: 907–13.
- 41, . Centrosome anomalies in cancer: from early observations to animal modes. In: NiggE, ed. Centrosomes in development and disease. Weinheim: Wiley-VCH, 2004. 323–33.
- 42, . The good, the bad and the ugly: the practical consequences of centrosome amplification. Curr Opin Cell Biol 2004; 16: 49–54.
- 43, , . Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic phenotypes. Cancer Res 1993; 53: 5339–44.
- 44, , , , . Serial transplants of DMBA-induced mammary tumors in fischer rats as model system for human breast cancer: V. Myoepithelial-mesenchymal conversion during passaging as possible cause for modulation of pineal-tumor interaction. Exp Toxicol Pathol 2000; 52: 93–101.
- 45, . Polyclonal development of mouse mammary preneoplastic nodules. Cancer Res 2004; 64: 857–63.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
1097-0215/asset/cover.gif?v=1&s=9bea5e55449dab2cff7ad3b06277cc9745417a23)