Fast Track

You have full text access to this OnlineOpen article

Prospective study of vitamins C, E, and A and carotenoids and risk of oral premalignant lesions in men

  1. Nancy Nairi Maserejian1,2,3,†,*,
  2. Edward Giovannucci1,4,5,
  3. Bernard Rosner4,
  4. Kaumudi Joshipura1,2,6

Article first published online: 12 DEC 2006

DOI: 10.1002/ijc.22448

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 5, pages 970–977, 1 March 2007

Additional Information

How to Cite

Maserejian, N. N., Giovannucci, E., Rosner, B. and Joshipura, K. (2007), Prospective study of vitamins C, E, and A and carotenoids and risk of oral premalignant lesions in men. Int. J. Cancer, 120: 970–977. doi: 10.1002/ijc.22448

Author Information

  1. 1

    Department of Epidemiology, Harvard School of Public Health, Boston, MA

  2. 2

    Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA

  3. 3

    New England Research Institutes, Watertown, MA

  4. 4

    Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

  5. 5

    Department of Nutrition, Harvard School of Public Health, Boston, MA

  6. 6

    Division of Dental Public Health, School of Dentistry, University of Puerto Rico Medical Science Campus, San Juan, PR

  1. †

    Fax: +1-617-926-0144/8246.

*New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA

Publication History

  1. Issue published online: 19 JAN 2007
  2. Article first published online: 12 DEC 2006

Funded by

  • NIH. Grant Numbers: T32DE07151, HL035464, CA055075

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (115K)

References

  • 1
    Pryor WA. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. Environ Health Perspect 1997; 105 ( Suppl 4): 875–82.
  • 2
    Borek C. Dietary antioxidants and human cancer. Integr Cancer Ther 2004; 3: 333–41.
  • 3
    Bendich A, Olson JA. Biological actions of carotenoids. FASEB J 1989; 3: 1927–32.
  • 4
    Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nutr J 2003; 2: 7.
  • 5
    Debier C, Larondelle Y. Vitamins A and E: metabolism, roles and transfer to offspring. Br J Nutr 2005; 93: 153–74.
  • 6
    McLaughlin JK, Gridley G, Block G, Winn DM, Preston-Martin S, Schoenberg JB, Greenberg RS, Stemhagen A, Austin DF, Ershow AG, et al. Dietary factors in oral and pharyngeal cancer. J Natl Cancer Inst 1988; 80: 1237–43.
  • 7
    Zheng T, Boyle P, Willett WC, Hu H, Dan J, Evstifeeva TV, Niu S, MacMahon B. A case-control study of oral cancer in Beijing, People's Republic of China. Associations with nutrient intakes, foods and food groups. Eur J Cancer B Oral Oncol 1993; 29: 45–55.
  • 8
    De Stefani E, Ronco A, Mendilaharsu M, Deneo-Pellegrini H. Diet and risk of cancer of the upper aerodigestive tract. II. Nutrients. Oral Oncol 1999; 35: 22–6.
  • 9
    De Stefani E, Oreggia F, Boffetta P, Deneo-Pellegrini H, Ronco A, Mendilaharsu M. Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay. Oral Oncol 2000; 36: 47–53.
  • 10
    Negri E, Franceschi S, Bosetti C, Levi F, Conti E, Parpinel M, La Vecchia C. Selected micronutrients and oral and pharyngeal cancer. Int J Cancer 2000; 86: 122–7.
    Direct Link:
  • 11
    Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003; 78: 559S–69S.
  • 12
    Bairati I, Meyer F, Gelinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Tetu B, Harel F, Masse B, Vigneault E, Vass S, et al. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 2005; 97: 481–8.
  • 13
    van Zandwijk N, Dalesio O, Pastorino U, de Vries N, van Tinteren H. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst 2000; 92: 977–86.
  • 14
    Marshall JR, Boyle P. Nutrition and oral cancer. Cancer Causes Control 1996; 7: 101–11.
  • 15
    Minasian A, Dwyer JT. Nutritional implications of dental and swallowing issues in head and neck cancer. Oncology (Williston Park) 1998; 12: 1155–62. Discussion 62–9.
  • 16
    Mehta FS, Gupta PC, Pindborg JJ. Chewing and smoking habits in relation to precancer and oral cancer. J Cancer Res Clin Oncol 1981; 99: 35–9.
  • 17
    Melrose RJ. Premalignant oral mucosal diseases. J Calif Dent Assoc 2001; 29: 593–600.
  • 18
    Gupta PC, Mehta FS, Daftary DK, Pindborg JJ, Bhonsle RB, Jalnawalla PN, Sinor PN, Pitkar VK, Murti PR, Irani RR, Shah HT, Kadam PM, et al. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers. Community Dent Oral Epidemiol 1980; 8: 283–333.
    Direct Link:
  • 19
    Silverman S,Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer 1984; 53: 563–8.
    Direct Link:
  • 20
    Bouquot JE, Weiland LH, Kurland LT. Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935–1984. Oral Surg Oral Med Oral Pathol 1988; 65: 199–207.
  • 21
    Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 79: 321–9.
  • 22
    Kaugars GE, Brandt RB, Chan W, Carcaise-Edinboro P. Evaluation of risk factors in smokeless tobacco-associated oral lesions. Oral Surg Oral Med Oral Pathol 1991; 72: 326–31.
  • 23
    Kaugars GE, Riley WT, Brandt RB, Burns JC, Svirsky JA. The prevalence of oral lesions in smokeless tobacco users and an evaluation of risk factors. Cancer 1992; 70: 2579–85.
    Direct Link:
  • 24
    Cianfriglia F, Manieri A, Di Gregorio DA, Di Iorio AM. Retinol dietary intake and oral leukoplakia development. J Exp Clin Cancer Res 1998; 17: 331–6.
  • 25
    Gupta PC, Hebert JR, Bhonsle RB, Sinor PN, Mehta H, Mehta FS. Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. Oral Dis 1998; 4: 200–6.
    Direct Link:
  • 26
    Gupta PC, Hebert JR, Bhonsle RB, Murti PR, Mehta H, Mehta FS. Influence of dietary factors on oral precancerous lesions in a population-based case-control study in Kerala, India. Cancer 1999; 85: 1885–93.
  • 27
    Hebert JR, Gupta PC, Bhonsle RB, Mehta H, Zheng W, Sanderson M, Teas J. Dietary exposures and oral precancerous lesions in Srikakulam District, Andhra Pradesh, India. Public Health Nutr 2002; 5: 303–12.
  • 28
    Caan B, Hiatt RA, Owen AM. Mailed dietary surveys: response rates, error rates, and the effect of omitted food items on nutrient values. Epidemiology 1991; 2: 430–6.
  • 29
    Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc 1993; 93: 318–23.
  • 30
    Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E. Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Diet Assoc 1993; 93: 284–96.
  • 31
    Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis CS, Mulokozi G. Carotenoid content of thermally processed tomato-based food products. J Agric Food Chem 1995; 43: 579–86.
  • 32
    Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC. Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 1992; 135: 1114–26. Discussion 27–36.
  • 33
    Ascherio A, Stampfer MJ, Colditz GA, Rimm EB, Litin L, Willett WC. Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and women. J Nutr 1992; 122: 1792–801.
  • 34
    Michaud DS, Giovannucci EL, Ascherio A, Rimm EB, Forman MR, Sampson L, Willett WC. Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database. Cancer Epidemiol Biomarkers Prev 1998; 7: 283–90.
  • 35
    Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997; 65: 1220S–28S. Discussion 29S–31S.
  • 36
    Willett WC, Buzzard IM. Foods and nutrients. In: WillettWC, ed. Nutritional epidemiology, 2nd edn., vol. 30. New York: Oxford University Press, 1998.
  • 37
    Maserejian NN, Joshipura KJ, Rosner BA, Giovannucci E, Zavras AI. Prospective study of alcohol consumption and risk of oral premalignant lesions in men. Cancer Epidemiol Biomarkers Prev 2006; 15: 774–81.
  • 38
    Maserejian NN, Giovannucci E, Rosner B, Zavras A, Joshipura K. Prospective study of fruits and vegetables and risk of oral premalignant lesions in men. Am J Epidemiol 2006; 164: 556–66.
  • 39
    Vinson JA, Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988; 48: 601–4.
  • 40
    DeRitter E, Cohen N, Rubin S. Physiological availability of dehydro-L-ascorbic acid and palmitoyl-L-ascorbic acid. Science 1951; 113: 628–31.
  • 41
    Pelletier O, Keith MO. Bioavailability of synthetic and natural ascorbic acid. J Am Diet Assoc 1974; 64: 271–5.
  • 42
    Gregory JF,III. Ascorbic acid bioavailability in foods and supplements. Nutr Rev 1993; 51: 301–3.
  • 43
    Mangels AR, Block G, Frey CM, Patterson BH, Taylor PR, Norkus EP, Levander OA. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr 1993; 123: 1054–61.
  • 44
    Nyyssonen K, Poulsen HE, Hayn M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J, Salonen R, Salonen JT. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. Eur J Clin Nutr 1997; 51: 154–63.
  • 45
    Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of β carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150–5.
  • 46
    Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Palmgren J, Freedman LS, Haapakoski J, Barrett MJ, Pietinen P, et al. α-Tocopherol and β-carotene supplements and lung cancer incidence in the α-tocopherol, β-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst 1996; 88: 1560–70.
  • 47
    Virtamo J, Pietinen P, Huttunen JK, Korhonen P, Malila N, Virtanen MJ, Albanes D, Taylor PR, Albert P. Incidence of cancer and mortality following α-tocopherol and β-carotene supplementation: a postintervention follow-up. JAMA 2003; 290: 476–85.
  • 48
    Liede K, Hietanen J, Saxen L, Haukka J, Timonen T, Hayrinen-Immonen R, Heinonen OP. Long-term supplementation with α-tocopherol and β-carotene and prevalence of oral mucosal lesions in smokers. Oral Dis 1998; 4: 78–83.
    Direct Link:
  • 49
    Liede KE, Alfthan G, Hietanen JH, Haukka JK, Saxen LM, Heinonen OP. β-Carotene concentration in buccal mucosal cells with and without dysplastic oral leukoplakia after long-term β-carotene supplementation in male smokers. Eur J Clin Nutr 1998; 52: 872–6.
  • 50
    Schneider C. Chemistry and biology of vitamin E. Mol Nutr Food Res 2005; 49: 7–30.
    Direct Link:
  • 51
    Paolini M, Abdel-Rahman SZ, Sapone A, Pedulli GF, Perocco P, Cantelli-Forti G, Legator MS. β-Carotene: a cancer chemopreventive agent or a co-carcinogen? Mutat Res 2003; 543: 195–200.
  • 52
    Mayne ST, Handelman GJ, Beecher G. β-Carotene and lung cancer promotion in heavy smokers—a plausible relationship? J Natl Cancer Inst 1996; 88: 1513–15.
  • 53
    Perocco P, Paolini M, Mazzullo M, Biagi GL, Cantelli-Forti G. β-Carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on BALB/c 3T3 cells in vitro. Mutat Res 1999; 440: 83–90.
  • 54
    Liu C, Wang XD, Bronson RT, Smith DE, Krinsky NI, Russell RM. Effects of physiological versus pharmacological β-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis 2000; 21: 2245–53.
  • 55
    Liu C, Russell RM, Wang XD. Exposing ferrets to cigarette smoke and a pharmacological dose of β-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes. J Nutr 2003; 133: 173–9.
  • 56
    Palozza P, Serini S, Di Nicuolo F, Boninsegna A, Torsello A, Maggiano N, Ranelletti FO, Wolf FI, Calviello G, Cittadini A. β-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. Carcinogenesis 2004; 25: 1315–25.
  • 57
    Rosner B, Spiegelman D, Willett WC. Correction of logistic regression relative risk estimates and confidence intervals for measurement error: the case of multiple covariates measured with error. Am J Epidemiol 1990; 132: 734–45.
  • 58
    Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, Rimm EB. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004; 351: 2599–610.
View Full Article (HTML) Get PDF (115K)