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Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors
Article first published online: 12 DEC 2006
DOI: 10.1002/ijc.22468
Copyright © 2006 Wiley-Liss, Inc.
Additional Information
How to Cite
Pereira, M. A., Tao, L., Liu, Y., Li, L., Steele, V. E. and Lubet, R. A. (2007), Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int. J. Cancer, 120: 1150–1153. doi: 10.1002/ijc.22468
Publication History
- Issue published online: 19 JAN 2007
- Article first published online: 12 DEC 2006
- Manuscript Accepted: 11 OCT 2006
- Manuscript Received: 20 JUN 2006
Funded by
- U.S. National Cancer Institute. Grant Numbers: N01-CN-15125, 25126
References
- 1. The role of budesonide in adults and children with mild-to-moderate persistent asthma. J Asthma 2004; 41: 5–17.
- 2, , , , , . Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res 1197; 57: 5489–92.
- 3, , , , , , . Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis 2000; 21: 179–82.
- 4, , , , , , , , . Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis 2002; 23: 1185–92.
- 5, , , , . Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. Exp Lung Res 2005; 31: 155–63.
- 6, , , , . Mice with alteration in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res 2003; 63: 4389–95.
- 7, , , , , . Effect of chemopreventive agents on separate stages of progression of benzo[ α]pyrene induced lung tumors in A/J mice. Carcinogenesis 2004; 25: 197–201.
- 8, , , , . Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. Oncogene 2004; 23: 7746–52.
- 9, , , , , , . Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra™). Carcinogenesis, in press.
- 10, . Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 2000; 25: 402–8.
- 11, , , , , . Effect of long- and short-term treatment with targretin on DNA methylation and mRNA expression in vinyl carbamate-induced mouse lung tumors. Fourth Ann Frontiers Cancer Prev Res 2005; 166.
- 12. Hypomethylation: one side of a larger picture. Ann NY Acad Sci 2003; 983: 28–42.Direct Link:
- 13, , , , , . Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res 2002; 62: 6442–6.
- 14, , , , , . Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver. Carcinogenesis 2003; 24: 1935–40.
- 15, , , , , , . Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol 2004; 24: 8862–71.
- 16, , , . The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin Cancer Res 2004; 10: 4589–96.
- 17, , . DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin Cancer Biol 2002; 12: 389–98.

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