The first two authors contributed equally to this work.
Cancer Cell Biology
CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
Article first published online: 4 JAN 2007
Copyright © 2006 Wiley-Liss, Inc.
International Journal of Cancer
Volume 120, Issue 7, pages 1444–1450, 1 April 2007
How to Cite
Yin, S., Li, J., Hu, C., Chen, X., Yao, M., Yan, M., Jiang, G., Ge, C., Xie, H., Wan, D., Yang, S., Zheng, S. and Gu, J. (2007), CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int. J. Cancer, 120: 1444–1450. doi: 10.1002/ijc.22476
- Issue published online: 30 JAN 2007
- Article first published online: 4 JAN 2007
- Manuscript Accepted: 23 OCT 2006
- Manuscript Received: 18 AUG 2006
- National Key Program for Basic Research of China. Grant Numbers: 2002CB513104, 2003CB515500, 2004CB518704
- Shanghai Science and Technology Program. Grant Numbers: 05JC14028, 054119602
- hepatocellular carcinoma;
Recently increasing reported data have suggested that only a small subset of cancer cells possess capability to initiate malignancies including leukemia and solid tumors, which was based on investigation in these cells displaying a distinct surface marker pattern within the primary cancers. CD133 is a putative hematopoietic and neuronal stem-cell marker, which was also considered as a tumorigenic marker in brain and prostate cancer. We hypothesized that CD133 was a marker closely correlated with tumorigenicity, since it was reported that CD133 expressed in human fetal liver and repairing liver tissues, which tightly associated with hepatocarcinogenesis. Our findings showed that a small population of CD133 positive cells indeed exists in human hepatocellular carcinoma (HCC) cell lines and primary HCC tissues. From SMMC-7721 cell line, CD133+ cells isolated by MACS manifested high tumorigenecity and clonogenicity as compared with CD133− HCC cells. The implication that CD133 might be one of the markers for HCC cancer stem-like cells needed further investigation. © 2006 Wiley-Liss, Inc.