Low adiponectin levels are associated with renal cell carcinoma: A case-control study

Authors

  • Themistoklis N. Spyridopoulos,

    1. Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Athens, Greece
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  • Eleni Th. Petridou,

    Corresponding author
    1. Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Athens, Greece
    2. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    • Department of Hygiene and Epidemiology, AthensUniversity Medical School, 75 Mikras Asias Str, Goudi, Athens 11527, Greece
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    • Fax: +30-210-7462105.

  • Alkistis Skalkidou,

    1. Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Athens, Greece
    2. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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  • Nick Dessypris,

    1. Department of Hygiene and Epidemiology, Athens University Medical School, Goudi, Athens, Greece
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  • George P. Chrousos,

    1. 1st Department of Pediatrics, Athens University Medical School, Athens, Greece
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  • Christos S. Mantzoros,

    1. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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  • the Obesity and Cancer Oncology Group

    1. Obesity and Cancer Oncology Group: Members of the Renal Cancer study: Aristeides Giannopoulos, 1st Department of Urology, University of Athens, “Laikon Hospital”, Goudi, Athens, Greece; Gerasimos Alivizatos, 2nd Department of Urology, University of Athens, “Sismanoglion Hospital,” Marousi, Athens, Greece; George Vassilakis, Department of Urology, General Hospital of Athens “G. Gennimatas,” Xolargos, Athens, Greece; Theodore Kalogeropoulos, Department of Urology, “Saint Savas” Anticancer Hospital, Ampelokipoi, Athens, Greece
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Abstract

Adiponectin is a novel endogenous insulin sensitizer, secreted by mature adipocytes. Circulating levels of adiponectin are inversely associated with obesity and insulin resistance. Because obesity is a risk factor for renal cell carcinoma (RCC), we hypothesized that low adiponectin levels are associated with RCC. To evaluate this hypothesis, we conducted a case- control study of 70 patients with histologically confirmed RCC and 280 healthy controls matched by gender, age and county of residence. Study subjects were interviewed and blood samples were collected during a 32-month period in Athens, Greece. Serum adiponectin levels were statistically, significantly and inversely associated with RCC when compared with controls (OR = 0.76, p = 0.05) and this association remained practically unchanged after controlling for BMI; the introduction of waist to hip ratio along with adiponectin in the multiple logistic regression analysis model rendered the association between adiponectin and RCC risk insignificant, indicating that altered levels of adiponectin may mediate the effect of central or intra-abdominal obesity on RCC. Prospective studies as well as studies exploring underlying mechanisms are needed to fully explore the role of adiponectin in predicting future risk of RCC in humans. © 2006 Wiley-Liss, Inc.

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