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Atopy, exposure to pesticides and risk of non-Hodgkin lymphoma

  1. Claire M. Vajdic1,†,*,
  2. Lin Fritschi2,
  3. Andrew E. Grulich1,
  4. John M. Kaldor1,
  5. Geza Benke3,
  6. Anne Kricker4,
  7. Ann Maree Hughes5,
  8. Jennifer J. Turner6,
  9. Sam Milliken7,
  10. Chris Goumas4,
  11. Bruce K. Armstrong4,8

Article first published online: 8 FEB 2007

DOI: 10.1002/ijc.22602

Issue

International Journal of Cancer

International Journal of Cancer

Volume 120, Issue 10, pages 2271–2274, 15 May 2007

Additional Information

How to Cite

Vajdic, C. M., Fritschi, L., Grulich, A. E., Kaldor, J. M., Benke, G., Kricker, A., Hughes, A. M., Turner, J. J., Milliken, S., Goumas, C. and Armstrong, B. K. (2007), Atopy, exposure to pesticides and risk of non-Hodgkin lymphoma. Int. J. Cancer, 120: 2271–2274. doi: 10.1002/ijc.22602

Author Information

  1. 1

    National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, NSW, Australia

  2. 2

    Laboratory for Cancer Epidemiology, Western Australian Institute for Medical Research, Perth, WA, Australia

  3. 3

    Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, VIC, Australia

  4. 4

    School of Public Health, The University of Sydney, Sydney, NSW, Australia

  5. 5

    Epidemiology and Genetics Unit, University of York, York, United Kingdom

  6. 6

    Department of Anatomical Pathology, St. Vincent's Hospital, Sydney, NSW, Australia

  7. 7

    Department of Haematology, St. Vincent's Hospital, Sydney, NSW, Australia

  8. 8

    Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia

  1. †

    Fax: +612-9385-0920.

*National Centre in HIV Epidemiology and Clinical Research, University of NSW, Darlinghurst, NSW, Australia

  1. †

    Fax: +612-9385-0920.

Publication History

  1. Issue published online: 23 MAR 2007
  2. Article first published online: 8 FEB 2007
  3. Manuscript Accepted: 7 DEC 2006
  4. Manuscript Received: 22 OCT 2006

Funded by

  • National Health and Medical Research Council of Australia (NHMRC). Grant Number: 990920
  • The Cancer Council NSW
  • The University of Sydney Medical Foundation
  • Australian Government Department of Health and Ageing

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Keywords:

  • non-Hodgkin lymphoma;
  • risk;
  • case–control;
  • pesticides;
  • asthma;
  • atopy

Abstract

Pesticide exposure has been associated with non-Hodgkin lymphoma (NHL) risk in a number of studies, and two recent studies suggest that the increased risk may be confined to those with a history of asthma. We examined the interaction between occupational pesticide exposure and atopy on risk of NHL in an Australian population-based case–control study. Incident cases (n = 694) were diagnosed in New South Wales or the Australian Capital Territory between 2000 and 2001 and controls (n = 694) were randomly selected from electoral rolls and frequency-matched to cases by age, sex and State of residence. Occupational pesticide exposure was determined by an expert occupational hygienist's assessment of job-specific questionnaires administered by telephone. History of atopy (asthma, hay fever, eczema and food allergy) was self-reported. Logistic regression models included the three matching variables, ethnicity and sun exposure. The OR for NHL with substantial pesticide exposure and any history of asthma was 3.07 (95% CI 0.55–17.10) and with substantial pesticide exposure and no asthma history it was 4.23 (95% CI 1.76–10.16). The p-value for interaction was 0.29. A similar pattern of risk was observed for each of the pesticide subtypes; for asthma at various times of life; for hay fever, eczema, food allergy and any atopy, in men only and for follicular lymphomas only. Although this study had limited power, the findings do not suggest modification of the association between pesticide exposure and NHL risk by asthma or atopic disease more generally. © 2007 Wiley-Liss, Inc.

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