Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45
Article first published online: 9 MAR 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 121, Issue 1, pages 193–198, 1 July 2007
How to Cite
Chen, Z., Fu, L., Herrero, R., Schiffman, M. and Burk, R. D. (2007), Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45. Int. J. Cancer, 121: 193–198. doi: 10.1002/ijc.22632
- Issue published online: 24 APR 2007
- Article first published online: 9 MAR 2007
- Manuscript Accepted: 8 JAN 2007
- Manuscript Received: 12 OCT 2006
- National Cancer Institute. Grant Number: CA78527
- human papillomavirus;
- novel type;
Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations. © 2007 Wiley-Liss, Inc.