There may be a potential financial conflict of interest resulting from the professional status of the author as a director of a private company (Colonix Medical Ltd).
Cell exfoliation in the human colon: Myth, reality and implications for colorectal cancer screening †
Version of Record online: 9 MAR 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 120, Issue 11, pages 2281–2289, 1 June 2007
How to Cite
Loktionov, A. (2007), Cell exfoliation in the human colon: Myth, reality and implications for colorectal cancer screening . Int. J. Cancer, 120: 2281–2289. doi: 10.1002/ijc.22647
- Issue online: 27 MAR 2007
- Version of Record online: 9 MAR 2007
- Manuscript Accepted: 11 JAN 2007
- Manuscript Received: 14 JUN 2006
- EEDA (East of England Development Agency)
- colonic epithelium;
- cell exfoliation;
- mucocellular layer;
- neoplastic growth;
- colorectal cancer screening
Colonocyte exfoliation in the human colon constitutes a unique mechanism of cell population control that can undergo significant changes under different physiological and pathological conditions. Being closely related to the apoptosis and anoikis, cell exfoliation from colonic epithelium appears to be a relatively rare event in normal conditions, but its rate dramatically increases in neoplasia, when cell removal by apoptosis in situ does not function properly. Several studies show that significant numbers of exfoliated colonocytes are not lost in the faecal contents of the gut, but retained in the mucocellular layer overlying colonic mucosa. Recent observations allow hypothesizing that the mucocellular layer containing exfoliated colonocytes may gradually migrate distally, eventually leading to the accumulation of the cells exfoliated from malignant colorectal tumours on the surface of the rectal mucosa. Implications of exfoliated colonocyte analysis to colorectal cancer screening and early diagnosis are discussed. © 2007 Wiley-Liss, Inc.