Meat and meat-mutagen intake, doneness preference and the risk of colorectal polyps: The Tennessee colorectal polyp study

Authors

  • Aesun Shin,

    1. Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Martha J. Shrubsole,

    1. Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN
    2. VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN
    3. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Reid M. Ness,

    1. VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN
    2. Divison of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Huiyun Wu,

    1. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
    2. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Rashmi Sinha,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
    Search for more papers by this author
  • Walter E. Smalley,

    1. VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN
    2. Divison of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Yu Shyr,

    1. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
    2. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN
    Search for more papers by this author
  • Wei Zheng

    Corresponding author
    1. Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN
    2. VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN
    3. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
    • Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, S-1211 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232-2587, USA
    Search for more papers by this author
    • Fax: +615-322-1754.


Abstract

Although meat intake has been fairly consistently linked to the risk of colorectal cancer, only a few studies have evaluated meat intake by doneness level and the heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) produced by high temperature cooking of meat in relation to colorectal adenomatous and hyperplastic polyps. We evaluated these associations in a large colonoscopy-based case-control study. Included in this study were participants with adenomatous polyp only (n = 573), hyperplastic polyp only (n = 256), or both adenomatous and hyperplastic polyps (n = 199), and 1,544 polyp-free controls. In addition to information related to demographic and other lifestyle factors, meat intake by cooking method and doneness preference were obtained through telephone interviews. Polytomous logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals for the association between exposures and colorectal polyp risks. Presence of hyperplastic polyp was found to be positively associated with high consumption of total meat (ptrend = 0.076) or red meat (ptrend = 0.060), with an approximate 50–60% elevated risk observed in the highest vs. the lowest intake group. High intake of 2-amino-I-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo [4,5]quinoxaline (DiMeIQx) were associated with increased risk for hyperplastic polyp (ptrend = 0.036 and 0.038, respectively). With a possible exception of the intake of total well-done meats (ptrend = 0.055) or well-done red meats (ptrend = 0.074) with the risk of large adenomas, no other positive association was found specifically for the risk of adenomas with any of the exposure variables aforementioned. This study provides additional support for a positive association of high intake of red meat with colorectal adenomas, and suggests that high intake of meats and meat carcinogens may also be associated with hyperplastic polyps. © 2007 Wiley-Liss, Inc.

Ancillary