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Epidemiology
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Diabetes mellitus and risk of breast cancer: A meta-analysis
Article first published online: 30 MAR 2007
DOI: 10.1002/ijc.22717
Copyright © 2007 Wiley-Liss, Inc.
Additional Information
How to Cite
Larsson, S. C., Mantzoros, C. S. and Wolk, A. (2007), Diabetes mellitus and risk of breast cancer: A meta-analysis. Int. J. Cancer, 121: 856–862. doi: 10.1002/ijc.22717
Publication History
- Issue published online: 22 JUN 2007
- Article first published online: 30 MAR 2007
- Manuscript Accepted: 26 FEB 2007
- Manuscript Received: 3 JAN 2007
Funded by
- The Swedish Cancer Society
References
- 1,,,,. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047–53.
- 2Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2005. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2005. Accessed at http://www.cdc.gov/diabetes/pubs/factsheet05.htm on November 1, 2006.
- 3. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004; 88: 787–835, ix.
- 4. Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control 1996; 7: 605–25.
- 5. Insulin resistance, insulin-like growth factor I and breast cancer: a hypothesis. Int J Cancer 1995; 62: 403–6.Direct Link:
- 6,,,. Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia 2006; 49: 2819–23.
- 7,,. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 2005; 97: 1679–87.
- 8,,,,. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 2005; 92: 2076–83.
- 9,,. The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 2006; 4: 369–80.
- 10,,,,. Diabetes mellitus and breast cancer. Lancet Oncol 2005; 6: 103–11.
- 11,,,,,,,,,. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008–12.
- 12,. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–88.
- 13,. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539–58.Direct Link:
- 14,,,. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629–34.
- 15,,. Diabetes mellitus and cancer risk: a multisite case–control study. J Chronic Dis 1985; 38: 435–41.
- 16,,,,. Breast cancer risk and history of selected medical conditions linked with female hormones. Eur J Cancer 1990; 26: 781–5.
- 17,,,,. A case–control study of diabetes mellitus and cancer risk. Br J Cancer 1994; 70: 950–3.
- 18,,,,,. Selected medical conditions and risk of breast cancer. Br J Cancer 1997; 75: 1699–703.
- 19,,,,,,,. Breast cancer risk in young women and history of selected medical conditions. Int J Epidemiol 1999; 28: 816–23.
- 20,,,,,,. Metabolic disorders and breast cancer risk (United States). Cancer Causes Control 2001; 12: 875–80.
- 21,. A prospective study in general practice on breast-cancer risk in postmenopausal women. Int J Cancer 1974; 14: 153–60.Direct Link:
- 22,,,. Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus. J Chronic Dis 1982; 35: 13–19.
- 23,,,,,,. Cancer risk in patients with diabetes mellitus. Cancer Causes Control 1991; 2: 307–14.
- 24,,,,,,,,. Does body fat distribution promote familial aggregation of adult onset diabetes mellitus and postmenopausal breast cancer? Epidemiology 1994; 5: 102–8.
- 25,,. Cancer incidence in the National Health and Nutrition Survey I. Follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol Biomarkers Prev 1995; 4: 807–11.
- 26,,,,. Risk factors for primary breast cancer in Japan: 8-year follow-up of atomic bomb survivors. Prev Med 1997; 26: 144–53.
- 27,,,,,. Risk of endometrial and breast cancer in patients with diabetes mellitus. Int J Cancer 1997; 71: 360–3.Direct Link:
- 28,,,,,. Cancer and diabetes—A follow-up study of two population-based cohorts of diabetic patients. J Intern Med 1997; 241: 471–5.Direct Link:
- 29,,,,,,,. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 1997; 89: 1360–5.
- 30,,,,. Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities study. Am J Epidemiol 2002; 156: 349–52.
- 31,,,,,,. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. Diabetes Care 2003; 26: 1752–8.
- 32,,,,,,,,,,,. Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study. Br J Cancer 2005; 92: 2070–5.
- 33,,,,,. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 2005; 293: 194–202.
- 34,,,,,,. Site-specific cancer risk due to diabetes mellitus history: evidencefrom the Japan Collaborative Cohort (JACC) Study. Asian Pac J Cancer Prev 2006; 7: 253–9.
- 35,,,,. Diabetes mellitus and breast cancer: a retrospective population-based cohort study. Breast Cancer Res Treat 2006; 98: 349–56.
- 36,,,,,. Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 2006; 166: 1871–7.
- 37. Cancer mortality among diabetics. J Natl Cancer Inst 1970; 44: 673–86.
- 38,,,. Mortality from site-specific malignancies in type 2 diabetic patients from Verona. Diabetes Care 2003; 26: 1047–51.
- 39,,,,. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol 2004; 159: 1160–7.
- 40,,,,,. Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J Natl Cancer Inst 2003; 95: 1797–800.
- 41Centers for Disease Control and Prevention (CDC). Prevalence of diabetes and impaired fasting glucose in adults—United States, 1999–2000. MMWR Morb Mortal Wkly Rep 2003; 52: 833–7.
- 42,,,,,. Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence. J Biol Chem 2001; 276: 38023–8.
- 43,,,,. Mitogenic stimulation of human breast cancer cells in a growth factor-defined medium: synergistic action of insulin and estrogen. J Cell Physiol 1988; 134: 101–8.Direct Link:
- 44,. Insulin receptors in breast cancer: biological and clinical role. J Endocrinol Invest 1996; 19: 324–33.
- 45,,,,,,,. Insulin receptors in breast cancer. Ann NY Acad Sci 1996; 784: 173–88.Direct Link:
- 46,,,,,,,,,,, et al. Serum C-peptide levels and breast cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2006; 119: 659–67.Direct Link:
- 47,,. Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. Cancer Causes Control 2004; 15: 267–75.
- 48,,,,,. Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women. Asian Pac J Cancer Prev 2003; 4: 239–46.
- 49,,,,,,,,,. Population-based, case–control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2001; 10: 1207–11.
- 50,,,,,,,,,,. Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiol Biomarkers Prev 2002; 11: 1361–8.
- 51,,,,,,,. Serum insulin-like growth factor-I and breast cancer. Int J Cancer 2000; 88: 828–32.Direct Link:
- 52,,,,,,,,,,. Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control 2002; 13: 307–16.
- 53,,,,,,,,. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 2002; 20: 42–51.
- 54,,,,,,,. Association between diabetes mellitus and adverse characteristics of breast cancer at presentation. Eur J Cancer 2006; 42: 1077–82.
- 55,,. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on. Endocr Relat Cancer 2006; 13: 273–8.
- 56,,,. Regulation of sex hormone-binding globulin production by growth factors. Metabolism 1990; 39: 967–70.
- 57
- 58,,,. Circulating gonadotrophins and urinary oestrogens in postmenopausal diabetic women. Aust N Z J Obstet Gynaecol 1981; 21: 234–6.Direct Link:
- 59,,,,,. Androgens and estrogens in postmenopausal insulin-treated diabetic women. J Clin Endocrinol Metab 1989; 69: 946–9.
- 60,,,,,,,,,,, et al. Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 2005; 12: 1071–82.
- 61,,,. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002; 94: 606–16.
- 62,,,,,,. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 2006; 98: 1406–15.
- 63,,,,,,,,,,, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2005; 97: 755–65.

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