The first two authors contributed equally to this work.
Cancer Cell Biology
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Modulating metastasis by a lymphangiogenic switch in prostate cancer
Article first published online: 21 JUN 2007
DOI: 10.1002/ijc.22900
Copyright © 2007 Wiley-Liss, Inc.
Additional Information
How to Cite
Brakenhielm, E., Burton, J. B., Johnson, M., Chavarria, N., Morizono, K., Chen, I., Alitalo, K. and Wu, L. (2007), Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int. J. Cancer, 121: 2153–2161. doi: 10.1002/ijc.22900
Publication History
- Issue published online: 25 SEP 2007
- Article first published online: 21 JUN 2007
- Manuscript Accepted: 2 APR 2007
- Manuscript Received: 3 NOV 2006
Funded by
- NCI SPORE program. Grant Number: P50 CA092131
- California Cancer Research Program. Grant Number: 3NI0226
- UCLA RTPS Training program. Grant Number: T32-GM008652
- Swedish Wenner-Gren Foundations
References
- 1National Cancer Institute. Cancer Stat Facts: Surveillance, Epidemiology, and End Results (SEER) Program. Rockville, MD: NCI, 2006.
- 2, , , , , , , , , , . Pretreatment nomogram for prostate-specific antigen recurrence after radical prostatectomy or external-beam radiation therapy for clinically localized prostate cancer. J Clin Oncol 1999; 17: 168–72.
- 3, . Laparoscopic pelvic lymph node dissection in the staging of prostate cancer. Mt Sinai J Med 1999; 66: 26–30.
- 4, , , , , , , , , , , , et al. Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res 2004; 64: 9209–16.
- 5, , , , , . Natural history of progression after PSA elevation following radical prostatectomy. JAMA 1999; 281: 1591–7.
- 6, , , , . Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol 2004; 172: 910–14.
- 7, , , , , . Cancer control with radical prostatectomy alone in 1,000 consecutive patients. J Urol 2002; 167: 528–34.
- 8, , , , , . Risk of prostate carcinoma death in patients with lymph node metastasis. Cancer 2001; 91: 66–73.Direct Link:
- 9, , , , , , , , , . Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7: 192–8.
- 10, , , , , , , , , . VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001; 7: 186–91.
- 11, , . Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 2005; 7: 121–7.
- 12, , , , , , , , , , , , et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. Embo J 2001; 20: 672–82.
- 13, . Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002; 1: 219–27.
- 14, , , , , , , . Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer. Clin Cancer Res 2004; 10: 5137–44.
- 15, , , , , . Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease. Clin Cancer Res 2005; 11: 584–93.
- 16, , , , . Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 2005; 65: 222–30.Direct Link:
- 17, , , , , , . Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis. Br J Cancer 1999; 80: 309–13.
- 18, , , , , , , , , , , . Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res 2005; 65: 6901–9.
- 19, , , , , , . The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo. Int J Mol Med 2005; 16: 723–8.
- 20, , , . A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med 1999; 5: 280–5.
- 21, , , , , , , , . Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. Cancer Res 1999; 59: 5030–6.
- 22, , , , , , , . Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nat Med 2002; 8: 891–7.
- 23, , , , , , . Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis. Clin Exp Metastasis 2003; 20: 733–44.
- 24, , , , , , , , , , . Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nat Med 1997; 3: 402–8.
- 25, , , , , , , . Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med 2005; 11: 346–52.
- 26, , , , , , . A third-generation lentivirus vector with a conditional packaging system. J Virol 1998; 72: 8463–71.
- 27, . Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA 2002; 99: 377–82.
- 28, , , , , , , . Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004; 101: 2476–81.
- 29, , , , , , , . Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003; 9: 604–13.
- 30, , , , , , , . Advancing animal models of neoplasia through in vivo bioluminescence imaging. Eur J Cancer 2002; 38: 2128–36.
- 31, , , , , . Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA 1993; 90: 5021–5.
- 32, , , , , , , , . Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 1998; 95: 14389–94.
- 33, , , , , , , , , , , . The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 2006; 9: 209–23.
- 34, , , , , , . Molecular pathway for cancer metastasis to bone. J Biol Chem 2003; 278: 39044–50.
- 35, , , , , , , , , . A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim 1999; 35: 403–9.
- 36, , . Tracking micrometastasis to multiple organs with lacZ-tagged CWR22R prostate carcinoma cells. J Histochem Cytochem 2000; 48: 643–51.
- 37, , , , , , , , . A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. Embo J 1996; 15: 290–8.
- 38, , , , , . Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Mod Pathol 2006; 19: 392–8.
- 39, , , , , . Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res 2005; 65: 9789–98.
- 40, , , , , , , . The role of the lymphatic system and its specific growth factor, vascular endothelial growth factor C, for lymphogenic metastasis in prostate cancer. BJU Int 2006; 98: 903–6.Direct Link:
- 41, , , , , , , , . Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res 2006; 66: 8065–75.
- 42, , , . Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis. Cancer Res 2006; 66: 9566–75.
- 43, , , , , , , , , . Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 2002; 161: 947–56.
- 44, , , , , . VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005; 201: 1089–99.
- 45, , , , , , , , . Visualization of a primary antitumor immune response by positron emission tomography. Proc Natl Acad Sci USA 2005; 102: 17412–7.

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