Victor A. Levin is a founder of VBL Pharmaceuticals Inc., a company that intends to seek United States FDA approval for DFMO in the treatment of anaplastic gliomas.
Cancer Therapy
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Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO–PCV chemotherapy
Article first published online: 20 JUN 2007
DOI: 10.1002/ijc.22914
Copyright © 2007 Wiley-Liss, Inc.
Additional Information
How to Cite
Levin, V. A., Jochec, J. L., Shantz, L. M. and Aldape, K. D. (2007), Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO–PCV chemotherapy. Int. J. Cancer, 121: 2279–2283. doi: 10.1002/ijc.22914
Publication History
- Issue published online: 25 SEP 2007
- Article first published online: 20 JUN 2007
- Manuscript Accepted: 4 MAY 2007
- Manuscript Received: 30 MAR 2007
Funded by
- Commonwealth Foundation for Cancer Research
- NIH. Grant Numbers: CA 82768, U10 CA 45809
References
- 1, , , , , , , , , . Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). Clin Cancer Res 1998; 4: 1661–72.
- 2, , , , , . Selective inhibition of tyrosine kinases—a new therapeutic principle in oncology. Onkologie 2001; 24: 65–71.
- 3, , , , , , , , , , , , et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099–109.
- 4, , , , , , , , , , , , et al. Erlotinib in lung cancer—molecular and clinical predictors of outcome. N Engl J Med 2005; 353: 133–44.
- 5, , , , , , , , , . Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors. Cancer Treat Rep 1987; 71: 459–64.
- 6, , , , , . Treatment of recurrent gliomas with eflornithine. J Natl Cancer Inst 1992; 84: 1432–7.
- 7, , , , . Treatment of recurrent gliomas with 1,3-bis(2-chloroethyl)-1-nitrosoureaand alpha-difluoromethylornithine. Neurosurgery 1989; 24: 806–9.
- 8, , , , , , , , , , , . Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosurea, vincristine (DFMO–PCV) versus PCV for glioblastoma multiforme. Clin Cancer Res 2000; 6: 3878–84.
- 9, , , , , , , , , , , . Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. Clin Cancer Res 2003; 9: 981–90.
- 10, , , , . Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine. J Histochem Cytochem 2004; 52: 1467–74.
- 11, . Ornithine decarboxylase induction in transformation by H-Ras and RhoA. Cancer Res 1998; 58: 2748–53.
- 12, , , , , , , , , , . 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin. Clin Cancer Res 1998; 4: 117–30.
- 13, , . Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic ag onist-induced cardiac hypertrophy. Biochem J 2001; 358: 25–32.

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