Inflammation and cancer: An ancient link with novel potentials
Article first published online: 24 SEP 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 121, Issue 11, pages 2373–2380, 1 December 2007
How to Cite
Perwez Hussain, S. and Harris, C. C. (2007), Inflammation and cancer: An ancient link with novel potentials. Int. J. Cancer, 121: 2373–2380. doi: 10.1002/ijc.23173
- Issue published online: 25 SEP 2007
- Article first published online: 24 SEP 2007
- Manuscript Accepted: 31 AUG 2007
- Manuscript Received: 13 JUL 2007
- nitric oxide;
Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. © 2007 Wiley-Liss, Inc.