Fax: +301-496-0497
1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
Special Section
You have full text access to this OnlineOpen article
Inflammation and cancer: An ancient link with novel potentials
Article first published online: 24 SEP 2007
DOI: 10.1002/ijc.23173
Copyright © 2007 Wiley-Liss, Inc.
Additional Information
How to Cite
Perwez Hussain, S. and Harris, C. C. (2007), Inflammation and cancer: An ancient link with novel potentials. Int. J. Cancer, 121: 2373–2380. doi: 10.1002/ijc.23173
- †
Fax: +301-496-0497
Publication History
- Issue published online: 25 SEP 2007
- Article first published online: 24 SEP 2007
- Manuscript Accepted: 31 AUG 2007
- Manuscript Received: 13 JUL 2007
Funded by
- NIH
- NCI
- CCR
- Abstract
- Article
- References
- Cited By
Keywords:
- inflammation;
- microRNA;
- nitric oxide;
- cancer
Abstract
Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. © 2007 Wiley-Liss, Inc.