• 1
    Elliott S,Busse L,Spahr C,Sinclair AM. Anti-EpoR antibodies detect a 59-kDa EpoR protein. Blood 2006; 108: 1109.
  • 2
    Barber DL,Beattie BK,Mason JM,Nguyen MHH,Yoakim M,Neel BG,D'Andrea AD,Frank DA. A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation. Blood 2001; 97: 22307.
  • 3
    Sasaki R,Masuda S,Nagao M. Erythropoietin: multiple physiological functions and regulation of biosynthesis. Biosci Biotechnol Biochem 2000; 64: 177593.
  • 4
    Rizzo JD,Lichtin AE,Woolf SH,Seidenfeld J,Bennett CL,Cella D,Djulbegovic B,Goode MJ,Jakubowski AA,Lee SJ,Miller CB,Rarick MU, et al. Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology. Blood 2002; 100: 230320.
  • 5
    Glaspy JA. Cancer patient survival and erythropoietin. J Natl Compr Canc Netw 2005; 3: 796804.
  • 6
    Varlotto J,Stevenson MA. Anemia, tumor hypoxemia, and the cancer patient. Int J Radiat Oncol Biol Phys 2005; 63: 2536.
  • 7
    Vaupel P,Mayer A,Höckel M. Tumor hypoxia and malignant progression. Methods Enzymol 2004; 381: 33554.
  • 8
    Leyland-Jones B; BEST Investigators and Study Group. Breast cancer trial with erythropoietin terminated unexpectedly. Lancet Oncol 2003; 4: 45960.
  • 9
    Henke M,Laszing R,Rübe C,Schäfer U,Haase K-D,Schilcher B,Mose S,Beer KT,Burger U,Dougherty C,Frommhold H. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362: 125560.
  • 10
    Hardee ME,Arcasoy MO,Blackwell KL,Kirkpatrick JP,Dewhirst MW. Erythropoietin biology in cancer. Clin Cancer Res 2006; 12: 3329.
  • 11
    Elliott S,Sinclair AM,Begley CG. Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood 2006; 107: 18925.
  • 12
    Komatsu N,Nakauchi H,Miwa A,Ishihara T,Eguchi M,Moroi M,Okada M,Sato Y,Wada H,Yawata Y. Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res 1991; 51: 3418.
  • 13
    Hellwig-Burgel T,Rutkowski K,Metzen E,Fandrey J,Jelkmann W. Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999; 94: 15617.
  • 14
    Ebert BL,Firth JD,Ratcliffe PJ. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 1995; 270: 290839.
  • 15
    Maxwell PH,Dachs GU,Gleadle JM,Nicholls LG,Harris AL,Stratford IJ,Hankinson O,Pugh CW,Ratcliffe PJ. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 1997; 94: 81049.
  • 16
    Wolff M,Jelkmann W. Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures. Ann Hematol 1993; 66: 2731.
  • 17
    Westphal G,Niederberger E,Blum C,Wollman Y,Knoch TA,Rebel W,Debus J,Friedrich E. Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality. Tumori 2002; 88: 1509.
  • 18
    Winter SC,Shah KA,Campo L,Turley H,Leek R,Corbridge RJ,Cox GJ,Harris AL. Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma. Clin Cancer Res 2005; 11: 761420.
  • 19
    Acs G,Zhang PJ,McGrath CM,Acs P,McBroom J,Mohyeldin A,Liu S,Lu H,Verma A. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol 2003; 162: 1789806.
  • 20
    Acs G,Acs P,Beckwith SM,Pitts RL,Clements E,Wong K,Verma A. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res 2001; 61: 35615.
  • 21
    Lester RD,Jo M,Campana WM,Gonias SL. Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem 2005; 280: 392737.
  • 22
    Beleslin-Cokic BB,Cokic VP,Yu X,Weksler BB,Schechter AN,Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood 2004; 104: 207380.
  • 23
    Batra S,Perelman N,Luck LR,Shimada H,Malik P. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Lab Invest 2003; 83: 147787.
  • 24
    Acs G,Xu X,Chu C,Acs P,Verma A. Prognostic significance of erythropoietin expression in human endometrial carcinoma. Cancer 2004; 100: 237686.
  • 25
    Dagnon K,Pacary E,Commo F,Antoine M,Bernaudin M,Bernaudin JF,Callard P. Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas. Clin Cancer Res 2005; 11: 9939.
  • 26
    Arcasoy MO,Amin K,Chou SC,Haroon ZA,Varia M,Raleigh JA. Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. Clin Cancer Res 2005; 11: 207.
  • 27
    Hoogsteen IJ,Peeters WJ,Marres HA,Rijken PF,van den Hoogen FJ,van der Kogel AJ,Kaanders JH. Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas. Radiother Oncol 2005; 76: 21318.
  • 28
    Mohyeldin A,Lu H,Dalgard C,Lai SY,Cohen N,Acs G,Verma A. Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. Neoplasia 2005; 7: 53743.
  • 29
    Kumar SM,Acs G,Fang D,Herlyn M,Elder DE,Xu X. Functional erythropoietin autocrine loop in melanoma. Am J Pathol 2005; 166: 82330.
  • 30
    Neumann D,Wikstrom L,Watowich SS,Lodish HF. Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J Biol Chem 1993; 268: 1363949.
  • 31
    Arcasoy MO,Jiang X,Haroon ZA. Expression of erythropoietin receptor splice variants in human cancer. Biochem Biophys Res Commun 2003; 307: 9991007.
  • 32
    Brown WM,Maxwell P,Graham ANJ,Yakkundi A,Dunlop EA,Shi Z,Johnston PG,Lappin TRJ. Erythropoietin receptor expression in non-small cell lung carcinoma: a question of antibody specificity. Stem Cells 2007; 25: 71822.
  • 33
    Tartakoff AM,Vassalli P. Lectin-binding sites as markers of Golgi subcompartments: proximal-to-distal maturation of oligosaccharides. J Cell Biol 1983; 97: 12438.
  • 34
    Dunlop EA,Percy MJ,Boland MP,Maxwell AP,Lappin TR. Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin. Neurodegener Dis 2006; 3: 94100.
  • 35
    Constantinescu SN,Ghaffari S,Lodish HF. The erythropoietin receptor: structure, activation and intracellular signal transduction. Trends Endocrinol Metab 1999; 10: 1823.
  • 36
    Huang LJ,Constantinescu SN,Lodish HF. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 2001; 8: 132738.
  • 37
    Silva M,Benito A,Sanz C,Prosper F,Ekhterae D,Nunez G,Fernandez-Luna JL. Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines. J Biol Chem 1999; 274: 221659.
  • 38
    Berdel WE,Oberberg D,Reufi B,Thiel E. Studies on the role of recombinant human erythropoietin in the growth regulation of human nonhematopoietic tumor cells in vitro. Ann Hematol 1991; 63: 58.
  • 39
    Rosti V,Pedrazzoli P,Ponchio L,Zibera C,Novella A,Lucotti C,Della-Cuna GR,Cazzola M. Effect of recombinant human erythropoietin on hematopoietic and non-hematopoietic malignant cell growth in vitro. Haematologica 1993; 78: 20812.
  • 40
    Mundt D,Berger MR,Bode G. Effect of recombinant human erythropoietin on the growth of human tumor cell lines in vitro. Micro-titertec-tetrazolium assay. Arzneimittelforschung 1992; 42: 925.
  • 41
    Liu WM,Powles T,Shamash J,Propper D,Oliver T,Joel S. Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivity. Oncogene 2004; 23: 98190.
  • 42
    LaMontagne KR,Butler J,Marshall DJ,Tullai J,Gechtman Z,Hall C,Meshaw A,Farrell FX. Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models. Mol Cancer Ther 2006; 5: 34755.
  • 43
    Gewirtz DA,Di X,Walker TD,Sawyer ST. Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs. Clin Cancer Res 2006; 12: 22328.
  • 44
    Westenfelder C,Baranowski RL. Erythropoietin stimulates proliferation of human renal carcinoma cells. Kidney Int 2000; 58: 64757.
  • 45
    Feldman L,Wang Y,Rhim JS,Bhattacharya N,Loda M,Sytkowski AJ. Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells. Prostate 2006; 66: 13545.
  • 46
    Carvalho G,Lefaucheur C,Cherbonnier C,Metivier D,Chapel A,Pallardy M,Bourgeade MF,Charpentier B,Hirsch F,Kroemer G. Chemosensitization by erythropoietin through inhibition of the NF-κB rescue pathway. Oncogene 2005; 24: 73745.
  • 47
    Leist M,Ghezzi P,Grasso G,Bianchi R,Villa P,Fratelli M,Savino C,Bianchi M,Nielsen J,Gerwien J,Kallunki P,Larsen AK, et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 2004; 305: 23942.
  • 48
    Brines M,Grasso G,Fiordaliso F,Sfacteria A,Ghezzi P,Fratelli M,Latini R,Xie QW,Smart J,Su-Rick CJ,Pobre E,Diaz D, et al. Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor. Proc Natl Acad Sci USA 2004; 101: 1490712.
  • 49
    Um M,Gross AW,Lodish HF. A “classical” homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signalling 2007; 19: 63445.