Trends in oesophageal cancer incidence and mortality in Europe

Authors

  • Cristina Bosetti,

    Corresponding author
    1. Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa l9, Milan, Italy
    • Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa 19 - 20156 Milan, Italy
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    • Fax: +39-023-3200231.

  • Fabio Levi,

    1. Unité d'épidémiologie du cancer et Registres vaudois et neuchâtelois des tumeurs, Centre Hospitalier Universitaire Vaudois et Institut de médecine sociale et préventive (IUMSP), Université de Lausanne, Bugnon 17, Lausanne, Switzerland
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  • Jacques Ferlay,

    1. International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon Cedex 08, Lyon, France
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  • Werner Garavello,

    1. Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa l9, Milan, Italy
    2. Clinica Otorinolaringoiatrica, DNTB, Università Milano-Bicocca, Via Donizetti 106, Monza, Italy
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  • Franca Lucchini,

    1. Unité d'épidémiologie du cancer et Registres vaudois et neuchâtelois des tumeurs, Centre Hospitalier Universitaire Vaudois et Institut de médecine sociale et préventive (IUMSP), Université de Lausanne, Bugnon 17, Lausanne, Switzerland
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  • Paola Bertuccio,

    1. Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa l9, Milan, Italy
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  • Eva Negri,

    1. Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa l9, Milan, Italy
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  • Carlo La Vecchia

    1. Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa l9, Milan, Italy
    2. Istituto di Statistica Medica e Biometria “G.A. Maccacaro,” Università degli Studi di Milano, Via Venezian 1, Milan, Italy
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Abstract

To monitor recent trends in mortality from oesophageal cancer in 33 European countries, we analyzed the data provided by the World Health Organization over the last 2 decades, using also joinpoint regression. For selected European cancer registration areas, we also analyzed incidence rates for different histological types. For men in the European Union (EU), age-standardized (world population) mortality rates were stable around 6/100,000 between the early 1980s and the early 1990s, and slightly declined in the last decade (5.4/100,000 in the early 2000s, annual percent change, APC = −1.1%). In several western European countries, male rates have started to level off or decline during the last decade (APC = −3.4% in France, and −3.0% in Italy). Also in Spain and the UK, which showed upward trends in the 1990s, the rates tended to level off in most recent years. A levelling of rates was observed only more recently in countries of central and eastern Europe, which had had substantial rises up to the late 1990s. Oesophageal cancer mortality rates remained comparatively low in European women, and overall EU female rates were stable around 1.1–1.2/100,000 over the last 2 decades (APC = −0.1%). In northern Europe a clear upward trend was observed in the incidence of oesophageal adenocarcinoma, and in Denmark and Scotland incidence of adenocarcinoma in men is now higher than that of squamous-cell carcinoma. Squamous-cell carcinoma remained the prevalent histological type in southern Europe. Changes in smoking habits and alcohol drinking for men, and perhaps nutrition, diet and physical activity for both sexes, can partly or largely explain these trends. © 2007 Wiley-Liss, Inc.

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