BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas
Article first published online: 12 DEC 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 122, Issue 8, pages 1778–1786, 15 April 2008
How to Cite
Idbaih, A., Marie, Y., Lucchesi, C., Pierron, G., Manié, E., Raynal, V., Mosseri, V., Hoang-Xuan, K., Kujas, M., Brito, I., Mokhtari, K., Sanson, M., Barillot, E., Aurias, A., Delattre, J.-Y. and Delattre, O. (2008), BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas. Int. J. Cancer, 122: 1778–1786. doi: 10.1002/ijc.23270
- Issue published online: 19 FEB 2008
- Article first published online: 12 DEC 2007
- Manuscript Accepted: 19 SEP 2007
- Manuscript Received: 19 APR 2007
- Institut Curie
- Ligue Nationale Contre le Cancer (Equipe Labellisée)
- Carte d'Identité des Tumeurs (CIT) Program of the Ligue Nationale Contre le Cancer
- BAC array CGH;
The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological characteristics, we have performed a genetic and clinical analysis of a series of gliomas. A total of 112 gliomas were analyzed by comparative genomic hybridization on a BAC array with a 1 megabase resolution. Altered regions were identified and correlation analysis enabled to retrieve significant associations and exclusions. Whole chromosomes (chrs) 1p and 19q losses with centromeric breakpoints and EGFR high level amplification were found to be mutually exclusive, permitting identification of 3 distinct, nonoverlapping groups of tumors with striking clinicopathological differences. Type A tumors with chrs 1p and 19q codeletion exhibited an oligodendroglial phenotype and a longer patient survival. Type B tumors were characterized by EGFR amplification. They harbored a WHO high grade of malignancy and a short patient survival. Finally, type C tumors displayed none of the previous patterns but the presence of chr 7 gain, chr 9p deletion and/or chr 10 loss. It included astrocytic tumors in patients younger than in type B and whose prognosis was highly dependent upon the number of alterations. A multivariate analysis based on a Cox model shows that age, WHO grade and genomic type provide complementary prognostic informations. Finally, our results highlight the potential of a whole-genome analysis as an additional diagnostic in cases of unclear conventional genetic findings. © 2007 Wiley-Liss, Inc.