Regulatory roles of tumor-suppressor proteins and noncoding RNA in cancer and normal cell functions
Article first published online: 7 DEC 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 122, Issue 8, pages 1687–1689, 15 April 2008
How to Cite
Garen, A. and Song, X. (2008), Regulatory roles of tumor-suppressor proteins and noncoding RNA in cancer and normal cell functions. Int. J. Cancer, 122: 1687–1689. doi: 10.1002/ijc.23285
- Issue published online: 19 FEB 2008
- Article first published online: 7 DEC 2007
- Manuscript Accepted: 12 OCT 2007
- Manuscript Received: 11 JUN 2007
- RNA viruses
We describe a mechanism for reversible regulation of gene transcription, mediated by a family of tumor-suppressor proteins (TSP) containing a DNA-binding domain (DBD) that binds to a gene and represses transcription, and RNA-binding domains (RBDs) that bind RNA, usually a noncoding RNA (ncRNA), forming a TSP/RNA complex that releases the TSP from a gene and reverses repression. This mechanism appears to be involved in the regulation of embryogenesis, oncogenesis, and steroidogenesis. Embryonic cells express high levels of RNA that bind to a TSP and prevent repression of proto-oncogenes that drive cell proliferation. The level of the RNA subsequently decreases in most differentiating cells, enabling a TSP to repress proto-oncogenes and stop cell proliferation. Oncogenesis can result when the level of the RNA fails to decrease in a proliferating cell or increases in a differentiated cell. This mechanism also regulates transcription of P450scc, the first gene in the steroidogenic pathway. © 2007 Wiley-Liss, Inc.